Exploring the impact of Agaricus bisporus on mitigating lead reproductive toxicity using the Caenorhabditis elegans model

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-06-16 DOI:10.1016/j.cbpc.2024.109963
Erika Leão Ajala Caetano , Francisco Javier Novoa San Miguel , Rocío Errázuriz León , Denise Grotto , Maria Fernanda Hornos Carneiro
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Abstract

Given that Agaricus bisporus, an edible mushroom, has demonstrated antioxidant properties, our investigation aimed to assess whether Agaricus bisporus could mitigate the toxic effects of lead (Pb) on Caenorhabditis elegans (C. elegans) model. A dose-response study was conducted involving Pb and Agaricus bisporus to determine appropriate doses. Subsequently, a co-exposure study utilizing C. elegans strains N2 and CL2166 was implemented, with groups designated as Control, Pb, Agaricus bisporus, and Pb + Agaricus bisporus. Our findings revealed that co-exposure to Pb + 100 mg/mL Agaricus bisporus resulted in reduced embryonic and larval lethality, increased brood size, and enhanced motility compared to nematodes exposed solely to Pb. Notably, our observations indicated a transfer of reproductive toxicity from nematode parents to their offspring. Thus, Agaricus bisporus may play a significant role in Pb detoxification, suggesting its potential as a natural antioxidant for neutralizing the detrimental effects of Pb on reproductive health.

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利用秀丽隐杆线虫模型探索双孢蘑菇对减轻铅生殖毒性的影响。
鉴于食用菌姬松茸(Agaricus bisporus)具有抗氧化特性,我们的研究旨在评估姬松茸能否减轻铅(Pb)对秀丽隐杆线虫(C. elegans)模型的毒性影响。研究人员进行了一项涉及铅和双孢蘑菇的剂量反应研究,以确定适当的剂量。随后,利用秀丽隐杆线虫菌株 N2 和 CL2166 进行了共同暴露研究,并将各组指定为对照组、铅组、双孢蘑菇组和铅+双孢蘑菇组。我们的研究结果表明,与仅暴露于铅的线虫相比,同时暴露于铅和 100 毫克/毫升的双孢蘑菇可降低胚胎和幼虫致死率、增加育雏规模并提高线虫的运动能力。值得注意的是,我们的观察结果表明,线虫亲代的生殖毒性转移到了子代。因此,双孢蘑菇可能在铅的解毒过程中发挥了重要作用,这表明它有可能成为一种天然抗氧化剂,用于中和铅对生殖健康的有害影响。
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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