Harmful planktonic Microcystis and benthic Oscillatoria-induced toxicological effects on the Asian clam (Corbicula fluminea): A survey on histopathology, behavior, oxidative stress, apoptosis and inflammation

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-06-16 DOI:10.1016/j.cbpc.2024.109961
Huiting Yang , Xiaohong Gu , Huihui Chen , Qingfei Zeng , Zhigang Mao , You Ge , Yujia Yao
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Abstract

Cyanobacterial blooms are worldwide distributed and threaten aquatic ecosystems and public health. The current studies mainly focus on the adverse impacts of planktonic cyanobacteria or pure cyanotoxins, while the benthic cyanobacteria-induced ecotoxic effects are relatively lacking. The cyanobacterial cell-induced toxic effects on aquatic organisms might be more serious and complex than the pure cyanotoxins and crude extracts of cyanobacteria. This study explored the chronic effects of toxin-producing planktonic Microcystis aeruginosa (producing microcystin) and benthic Oscillatoria sp. (producing cylindrospermopsin) on the behaviors, tissue structures, oxidative stress, apoptosis, and inflammation of the Asian clams (Corbicula fluminea) under 28-d exposure. The data showed that both M. aeruginosa and Oscillatoria sp. can decrease the behaviors associated with the feeding activity and induce tissue damage (i.e. gill and digestive gland) in clams. Furthermore, two kinds of cyanobacteria can alter the antioxidant enzyme activities and increase antioxidant, lipid oxidation product, and neurotransmitter degrading enzyme levels in clams. Moreover, two kinds of cyanobacteria can activate apoptosis-related enzyme activities and enhance the proinflammatory cytokine levels of clams. In addition, two kinds of cyanobacteria can disturb the transcript levels of genes linked with oxidative stress, apoptosis, and inflammation. These results suggested harmful cyanobacteria can threaten the survival and health of clams, while the benthic cyanobacteria-induced adverse effects deserve more attention. Our finding also indicated that it is necessary to focus on the entire algal cell-induced ecotoxicity when concerning the ecological impacts of cyanobacterial blooms.

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有害浮游微囊藻和底栖振子虫对亚洲蛤(Corbicula fluminea)的毒理影响:组织病理学、行为、氧化应激、细胞凋亡和炎症调查。
蓝藻水华分布于世界各地,威胁着水生生态系统和公众健康。目前的研究主要集中于浮游蓝藻或纯蓝藻毒素的不利影响,而底栖蓝藻诱导的生态毒性效应研究相对缺乏。与纯蓝藻毒素和蓝藻粗提物相比,蓝藻细胞对水生生物的毒性效应可能更为严重和复杂。本研究探讨了产毒浮游蓝藻铜绿微囊藻(产生微囊藻毒素)和底栖蓝藻鞘氨醇毒素(产生圆柱孢藻毒素)对亚洲蛤(Corbicula fluminea)暴露 28 天后的行为、组织结构、氧化应激、细胞凋亡和炎症的慢性影响。数据显示,铜绿微囊藻和鞘氨醇蓝藻都能降低蛤蜊的摄食行为,并诱发组织损伤(如鳃和消化腺)。此外,两种蓝藻还能改变蛤蜊体内抗氧化酶的活性,增加抗氧化剂、脂质氧化产物和神经递质降解酶的含量。此外,两种蓝藻还能激活凋亡相关酶的活性,提高蛤蜊体内促炎细胞因子的水平。此外,两种蓝藻还能干扰与氧化应激、细胞凋亡和炎症有关的基因转录水平。这些结果表明,有害蓝藻会威胁蛤蜊的生存和健康,而底栖蓝藻引起的不利影响值得更多关注。我们的发现还表明,在研究蓝藻水华的生态影响时,有必要关注整个藻细胞诱导的生态毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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