The spectrum of oestrogen receptor expression in endometrial carcinomas of no specific molecular profile

IF 3.9 2区医学 Q2 CELL BIOLOGY Histopathology Pub Date : 2024-06-18 DOI:10.1111/his.15241

Mona Alafraidi, Lynn Hoang, Brooke E. Howitt, Teri A. Longacre, Jessica N. McAlpine, Amy Jamieson, Naveena Singh, C Blake Gilks, Jennifer Pors

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Abstract

Aims

Decreased oestrogen receptor (ER) expression is a marker of poor prognosis in endometrial carcinomas (EC) of no specific molecular profile (NSMP), but the optimal cut-off to separate high-risk ‘low ER’ versus low-risk ‘high ER’ expression has not been defined. Here we characterised the distribution of ER staining in a cohort of ECs.

Methods and results

Biopsy specimens from 120 cases of NSMP EC were stained for ER and assigned an Allred score. In 66 additional cases ER staining of matched biopsy and hysterectomy were compared. Twelve of 120 tumours had an Allred score of 0–3, including three endometrioid carcinomas (EEA) (one G1, two G3), four clear cell carcinomas (CCC), two mesonephric-like adenocarcinoma (MLA) and one each of: gastric-type adenocarcinoma, carcinosarcoma and endometrial carcinoma NOS. Three had Allred scores of 4–5: two MLA and one high-grade carcinoma with yolk sac differentiation. Five had Allred scores of 6: four EEA (one G1, one G2, two G3) and one mixed clear cell and endometrioid carcinoma. The remaining 100 tumours with Allred scores ≥ 7 were all EEA (66 G1, 28 G2, five G3 and one grade unknown). Comparing the biopsy versus hysterectomy ER staining (n = 66), the results were within a single Allred score point, except two cases with strong diffuse expression in the biopsy (Allred 8) and moderate expression in the hysterectomy (Allred 5).

Conclusions

Most NSMP ECs (> 80%) show high ER expression (Allred score ≥ 7). All non-endometrioid carcinomas and a few endometrioid carcinomas had lower ER expression (Allred score ≤ 6) or were completely negative.

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无特殊分子特征的子宫内膜癌中雌激素受体的表达谱。

目的：雌激素受体（ER）表达减少是无特异性分子特征（NSMP）子宫内膜癌（EC）预后不良的标志，但区分高风险 "低ER "和低风险 "高ER "表达的最佳临界点尚未确定。在此，我们分析了一组 EC 中 ER 染色的分布特征：对120例NSMP EC的活检标本进行ER染色，并进行Allred评分。对另外 66 例匹配活检标本和子宫切除标本的ER染色进行比较。120例肿瘤中有12例的Allred评分为0-3分，包括3例子宫内膜样癌（EEA）（1例G1，2例G3）、4例透明细胞癌（CCC）、2例间质样腺癌（MLA）以及胃型腺癌、癌肉瘤和子宫内膜癌NOS各1例。3 例患者的 Allred 评分为 4-5 分：2 例为 MLA，1 例为卵黄囊分化的高级别癌。5 例 Allred 评分为 6 分：4 例 EEA（1 例 G1、1 例 G2、2 例 G3）和 1 例混合透明细胞癌和子宫内膜样癌。其余100个Allred评分≥7分的肿瘤均为EEA（66个G1、28个G2、5个G3和1个分级不明）。比较活检与子宫切除术的ER染色（n = 66），结果均在一个Allred评分点内，只有两例活检呈强弥漫表达（Allred 8），而子宫切除术呈中度表达（Allred 5）：结论：大多数非子宫内膜样癌（> 80%）表现为ER高表达（Allred评分≥7分）。所有非子宫内膜样癌和少数子宫内膜样癌的ER表达较低（Allred评分≤6）或完全阴性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histopathology 医学-病理学

CiteScore

10.20

自引率

4.70%

发文量

239

审稿时长

1 months

期刊介绍： Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.