Plakophilin 1 in carcinogenesis.

IF 3 2区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Carcinogenesis Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI:10.1002/mc.23779
Qiang Luo, Xiaojia Li, Keping Xie
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Abstract

Plakophilin 1 (PKP1) belongs to the desmosome family as an anchoring junction protein in cellular junctions. It localizes at the interface of the cell membrane and cytoplasm. Although PKP1 is a non-transmembrane protein, it may become associated with the cell membrane via transmembrane proteins such as desmocollins and desmogleins. Homozygous deletion of PKP1 results in ectodermal dysplasia-skin fragility syndrome (EDSF) and complete knockout of PKP1 in mice produces comparable symptoms to EDSF in humans, although mice do not survive more than 24 h. PKP1 is not limited to expression in desmosomal structures, but is rather widely expressed in cytoplasm and nucleus, where it assumes important cellular functions. This review will summarize distinct roles of PKP1 in the cell membrane, cytoplasm, and nucleus with an overview of relevant studies on its function in diverse types of cancer.

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Plakophilin 1 在致癌过程中的作用
Plakophilin 1(PKP1)属于脱膜小体家族,是细胞连接处的锚定连接蛋白。它定位于细胞膜和细胞质的交界处。虽然 PKP1 是一种非跨膜蛋白,但它可能通过跨膜蛋白(如脱绒毛球蛋白和脱绒毛球蛋白)与细胞膜结合。PKP1的同基因缺失会导致外胚层发育不良-皮肤脆弱综合征(EDSF),在小鼠中完全敲除PKP1会产生与人类EDSF相似的症状,尽管小鼠存活时间不会超过24小时。本综述将总结 PKP1 在细胞膜、细胞质和细胞核中的不同作用,并概述其在不同类型癌症中功能的相关研究。
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来源期刊
Molecular Carcinogenesis
Molecular Carcinogenesis 医学-生化与分子生物学
CiteScore
7.30
自引率
2.20%
发文量
112
审稿时长
2 months
期刊介绍: Molecular Carcinogenesis publishes articles describing discoveries in basic and clinical science of the mechanisms involved in chemical-, environmental-, physical (e.g., radiation, trauma)-, infection and inflammation-associated cancer development, basic mechanisms of cancer prevention and therapy, the function of oncogenes and tumors suppressors, and the role of biomarkers for cancer risk prediction, molecular diagnosis and prognosis.
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