Prenatal and childhood exposure to bisphenols and bone mineral density in 7-year-old children from the Odense Child Cohort

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES International journal of hygiene and environmental health Pub Date : 2024-06-18 DOI:10.1016/j.ijheh.2024.114408
Annika Sigvaldsen , Hanne Frederiksen , Frederik Damsgaard Højsager , Anna-Maria Andersson , Anders Juul , Henriette Boye , Marianne Skovsager Andersen , Tina Kold Jensen
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Abstract

Background

Bisphenol A (BPA) is a well-known endocrine disrupter used in several consumer products. Restricted use of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). While previous studies found no associations between prenatal BPA and BPF exposure and bone mineral density (BMD), two recent cohort studies found that prenatal BPS exposure was negatively associated with bone mineral density in the offspring.

Aim

To determine possible associations between maternal and child urinary bisphenol concentrations, BMD and bone mineral content (BMC) in 7-year-old healthy children.

Methods

Pregnant women were recruited in 2010–2012 to participate in the Odense Child Cohort (OCC), Denmark. Maternal urine samples were collected in gestational week 28 and urinary BPA concentration was measured by isotope diluted LC-MS/MS. The children delivered a urine sample at age 7 years in which BPA, BPF and BPS were measured by an extended LS-MS/MS method based on the original method. At age 7 years DXA scans were performed and BMC and Z-score for BMD calculated. Associations between osmolality adjusted urinary maternal BPA and child BPA, BPF and BPS concentrations and BMC and BMD Z-score were examined by multiple linear regression analysis adjusted for potential confounders. Additionally, a combined effect of the bisphenols were evaluated by including the sum of child urinary BPA, BPF and BPS concentrations in the statistical analyses.

Results

A total of 546 mothers and 453 children aged 7 years participated. BPA was detected in 84% and 96% of the maternal and child urine samples, respectively. We found no significant association between maternal urinary BPA concentration during pregnancy and BMC and BMD Z-score in 7-year-old children. In addition, no association between current bisphenol exposure in tertiles and bone density was found, interestingly, current BPA and summed bisphenol exposure in the highest 10% was associated with lower BMD Z-score at age 7-years, statistically significant for boys.

Conclusion

In these low exposed children we found no association between prenatal or current bisphenol exposure in tertiles and BMD in healthy children, however, the highest 10% exposed children had lower BMD, significant for boys, suggesting a negative impact with high bisphenol exposure. The short half-lives of bisphenols and the cross-sectional nature of the child exposure prompt more longitudinal studies to further clarify this topic.

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欧登塞儿童队列中 7 岁儿童的产前和童年双酚暴露与骨矿物质密度
背景双酚 A(BPA)是一种众所周知的内分泌干扰物,被用于多种消费品中。限制双酚 A 的使用导致双酚 F(BPF)和双酚 S(BPS)的使用增加。尽管之前的研究发现产前双酚 A 和双酚 F 暴露与骨矿物质密度 (BMD) 之间没有关联,但最近的两项队列研究发现产前双酚 S 暴露与后代的骨矿物质密度呈负相关。在孕 28 周时收集母体尿样,并通过同位素稀释 LC-MS/MS 方法测量尿液中的双酚 A 浓度。孩子们在 7 岁时采集尿样,在原有方法的基础上采用扩展的 LS-MS/MS 方法测量双酚 A、双酚 F 和双酚 S。7 岁时进行 DXA 扫描,并计算 BMC 和 BMD 的 Z 值。经渗透压调整的母体双酚 A 和儿童双酚 A、BPF 和 BPS 尿液浓度与 BMC 和 BMD Z 评分之间的关系通过多元线性回归分析进行了研究,并对潜在的混杂因素进行了调整。此外,通过将儿童尿液中双酚 A、双酚 F 和双酚 S 的浓度总和纳入统计分析,评估了双酚的综合影响。分别有 84% 和 96% 的母亲和儿童尿液样本中检测到双酚 A。我们发现,孕期母体尿液中的双酚 A 浓度与 7 岁儿童的 BMC 和 BMD Z 分数之间没有明显关联。结论 在这些低暴露儿童中,我们没有发现产前或当前双酚暴露量级与健康儿童的骨密度之间有任何关联,但是,暴露量最高的 10%儿童的骨密度较低,男孩的骨密度较低,这表明高双酚暴露量会产生负面影响。由于双酚的半衰期较短,而且儿童接触双酚的情况是横断面的,因此需要进行更多的纵向研究来进一步澄清这一问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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