Connecting the Dots: Gender, Sexuality, and Societal Influences on Cognitive Aging and Alzheimer's Disease.

Swati Verma, Sarvesh Paliwal, Debashish Paramanick, Chaitanya Narayan, Manasvi Saini
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Abstract

Alzheimer's disease (AD) has many etiologies and the impact of gender on AD changes throughout time. As a consequence of advancements in precision medical procedures and methodology, Alzheimer's disease is now better understood and treated. Several risk factors may be addressed to lower one's chances of developing Alzheimer's disease or associated dementia (ADRD). The presence of amyloid-α protein senile plaques, intracellular tau protein neurofibrillary tangles (NfTs), neurodegeneration, and neuropsychiatric symptoms (NPS) characterizes Alzheimer's disease. NPS is common in persons with Alzheimer's disease dementia, although its presentation varies widely. Gender differences might explain this clinical variability. The fundamental goal of this review research is to 1) emphasize the function of old age, sex, and gender in the development of Alzheimer's disease, dementia, and ADRD, and 2) explain the importance of sexual hormones, education, and APOE (Apolipoprotein E) status. This is a narrative summary of new ideas and concepts on the differences in the chance of developing dementia or Alzheimer's disease between men and women. A more thorough examination of risk and protective variables in both men and women might hasten research into the epidemiology of neurological illnesses such as dementia and Alzheimer's disease. Similarly, future preventive efforts should target men and women separately.

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连接点:认知老化和阿尔茨海默病的性别、性和社会影响。
阿尔茨海默病(AD)有多种病因,性别对阿尔茨海默病的影响也随时间而变化。由于精准医疗程序和方法的进步,现在人们对阿尔茨海默病有了更好的理解和治疗。要降低阿尔茨海默病或相关痴呆症(ADRD)的发病几率,可以从几个风险因素入手。淀粉样蛋白-α 蛋白老年斑、细胞内 tau 蛋白神经纤维缠结(NfTs)、神经变性和神经精神症状(NPS)的存在是阿尔茨海默病的特征。NPS 在阿尔茨海默病痴呆症患者中很常见,但其表现形式却千差万别。性别差异或许可以解释这种临床差异性。本综述研究的基本目标是:1)强调老年、性和性别在阿尔茨海默病、痴呆和 ADRD 发展过程中的作用;2)解释性激素、教育和 APOE(载脂蛋白 E)状态的重要性。这是对男女罹患痴呆症或阿尔茨海默病几率差异的新观点和新概念的叙述性总结。对男性和女性的风险和保护性变量进行更全面的研究可能会加快对痴呆症和阿尔茨海默病等神经系统疾病流行病学的研究。同样,未来的预防工作也应分别针对男性和女性。
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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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