Bidirectional two-sample Mendelian randomization study of association between smoking initiation and atrial fibrillation.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Tobacco Induced Diseases Pub Date : 2024-06-19 eCollection Date: 2024-01-01 DOI:10.18332/tid/189380

Ziyang Wu, Chengchun Tang, Dong Wang

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Abstract

Introduction: The relationship between smoking and heart disease has been frequently reported. Therefore, we aimed to explore the association between smoking initiation and atrial fibrillation.

Methods: Genetic association data pertaining to smoking initiation and atrial fibrillation were obtained from genome-wide association studies (GWAS). Phenotypically related single nucleotide polymorphisms (SNPs) were selected as instrumental variables. Inverse-variance weighted (IVW), weighted median, Mendelian randomization (MR), Egger regression, simple mode, and weighted mode methods were employed to perform the MR study. The association between smoking initiation and atrial fibrillation was evaluated using odds ratios (OR) and 95% confidence intervals (CI). Cochran's Q test was employed to assess heterogeneity among instrumental variables, utilizing the IVW and MR-Egger methods. The Egger-intercept method was employed to test for horizontal pleiotropy, and the 'leave-one-out' method was utilized for sensitivity analysis.

Results: The MR results for the effect of smoking initiation on atrial fibrillation (IVW, OR=1.11; 95% CI: 1.02-1.20, p=0.013) supported an association between smoking initiation and an increased likelihood of atrial fibrillation. In total, 85 SNPs were extracted from the GWAS pooled data as instrumental variables. The MR-Egger method indicated an intercept close to 0 (Egger intercept= -0.005, p=0.371), suggesting no horizontal pleiotropy in the selected instrumental variables. The 'leave-one-out' sensitivity analysis demonstrated that the results were robust and that no instrumental variables significantly influenced the results. Reverse MR analysis indicated no effect of atrial fibrillation on smoking initiation (IVW, OR=1.00; 95% CI: 0.99-1.02, p=0.684).

Conclusions: Smoking initiation has a significant impact on atrial fibrillation. However, atrial fibrillation did not influence smoking initiation. This study provides novel insights into the genetic relationships between smoking initiation and atrial fibrillation.

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吸烟与心房颤动关系的双向双样本孟德尔随机研究。

导言吸烟与心脏病之间的关系屡见报端。因此，我们旨在探讨吸烟与心房颤动之间的关系：方法：我们从全基因组关联研究（GWAS）中获得了吸烟与心房颤动的遗传关联数据。选择与表型相关的单核苷酸多态性（SNPs）作为工具变量。采用逆方差加权法（IVW）、加权中位法、孟德尔随机法（MR）、埃格回归法、简单模式法和加权模式法进行MR研究。研究采用几率比（OR）和 95% 置信区间（CI）来评估吸烟与心房颤动之间的关系。利用 IVW 和 MR-Egger 方法，采用 Cochran's Q 检验来评估工具变量之间的异质性。Egger截距法用于检验水平多向性，"leave-one-out "法用于敏感性分析：开始吸烟对心房颤动影响的 MR 结果（IVW，OR=1.11；95% CI：1.02-1.20，p=0.013）支持开始吸烟与心房颤动可能性增加之间存在关联。从 GWAS 汇集数据中总共提取了 85 个 SNPs 作为工具变量。MR-Egger方法显示截距接近0（Egger截距= -0.005，p=0.371），表明所选工具变量中没有水平褶积。剔除 "敏感性分析表明结果是稳健的，没有工具变量对结果产生显著影响。反向MR分析表明，心房颤动对开始吸烟没有影响（IVW，OR=1.00；95% CI：0.99-1.02，p=0.684）：结论：开始吸烟对心房颤动有重大影响。然而，心房颤动并不影响吸烟的开始。这项研究为研究吸烟与心房颤动之间的遗传关系提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.