Genomics in the kidney transplant clinic: the future standard of care?

IF 14.8 1区 医学 Q1 UROLOGY & NEPHROLOGY Kidney international Pub Date : 2024-06-19 DOI:10.1016/j.kint.2024.05.003
Emilie Cornec-Le Gall , Andrew J. Mallett
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Abstract

New evidence indicates potential benefit of genomics to illuminate nonkidney monogenic morbidity and mortality risk among kidney transplant recipients. This might be of direct relevance to an equivalent proportion of patients to those who harbor a monogenic kidney disease. Further evidence and replication are indicated, including a broadening potential range of monogenic and polygenic opportunities to improve clinical outcomes. Implementation will require such information, although it holds great promise.

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肾移植临床中的基因组学:未来的护理标准?
新的证据表明,基因组学在揭示肾移植受者中非肾脏单基因发病率和死亡率风险方面具有潜在的益处。这可能直接关系到与单基因肾脏病患者同等比例的患者。需要进一步的证据和复制,包括扩大单基因和多基因的潜在范围,以改善临床结果。尽管该研究大有可为,但其实施还需要此类信息。
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来源期刊
Kidney international
Kidney international 医学-泌尿学与肾脏学
CiteScore
23.30
自引率
3.10%
发文量
490
审稿时长
3-6 weeks
期刊介绍: Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.
期刊最新文献
Corrigendum to "Acute kidney injury genetic risks: taking it 1 SNP at a time." Kidney International 2024;106:188-190. Corrigendum to "Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats." Kidney International 2013;85:112-123. Hyponatremia associated with acute intermittent porphyria. Kidney failure and a reticulated dermatosis. Looking into the cholesterol crystal ball: is complement the answer?
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