Pub Date : 2026-02-09DOI: 10.1016/j.kint.2026.01.014
Liping Yu, Ubong S. Ekperikpe, Hunter W. Korsmo, Serena Zhao, Zhengzi Yi, Jonathan Haydak, Sean Lefferts, Kristin Meliambro, Kirk N. Campbell, Evren U. Azeloglu, Donald E. Kohan, Phillip J. McCown, Abhijit S. Naik, Edgar A. Otto, Börje Haraldsson, Weijia Zhang, Ilse S. Daehn
Increased endothelin-1 (ET1) and endothelin receptor A (ETA) signaling have been implicated in the pathogenesis of focal segmental glomerulosclerosis (FSGS). Previous studies have suggested that crosstalk between activated podocytes and glomerular endothelial cells (GECs) could contribute to the pathogenesis of FSGS.
{"title":"Podocyte derived endothelin-1 and endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis.","authors":"Liping Yu, Ubong S. Ekperikpe, Hunter W. Korsmo, Serena Zhao, Zhengzi Yi, Jonathan Haydak, Sean Lefferts, Kristin Meliambro, Kirk N. Campbell, Evren U. Azeloglu, Donald E. Kohan, Phillip J. McCown, Abhijit S. Naik, Edgar A. Otto, Börje Haraldsson, Weijia Zhang, Ilse S. Daehn","doi":"10.1016/j.kint.2026.01.014","DOIUrl":"https://doi.org/10.1016/j.kint.2026.01.014","url":null,"abstract":"Increased endothelin-1 (ET1) and endothelin receptor A (ET<ce:inf loc=\"post\">A</ce:inf>) signaling have been implicated in the pathogenesis of focal segmental glomerulosclerosis (FSGS). Previous studies have suggested that crosstalk between activated podocytes and glomerular endothelial cells (GECs) could contribute to the pathogenesis of FSGS.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"315 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1016/j.kint.2025.12.037
Fan-Chi Chang, Shuei-Liong Lin
{"title":"Angiopoietin-2 Inhibition and TIE2 Reactivation in Chronic Kidney Disease: The Next Step Forward","authors":"Fan-Chi Chang, Shuei-Liong Lin","doi":"10.1016/j.kint.2025.12.037","DOIUrl":"https://doi.org/10.1016/j.kint.2025.12.037","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"36 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.kint.2025.10.019
Helly A. Patel, Jiaxuan Wang, Caroline J. Zinn, Maya Learmonth, Xiaohui Bian, Diana Jurk, Lilach O. Lerman, Joy Wolfram, LaTonya J. Hickson
{"title":"Targeting Cellular Senescence in Diabetic Kidney Disease: Potential of Regenerative, Cell-based Therapies and Other Senotherapeutic Approaches","authors":"Helly A. Patel, Jiaxuan Wang, Caroline J. Zinn, Maya Learmonth, Xiaohui Bian, Diana Jurk, Lilach O. Lerman, Joy Wolfram, LaTonya J. Hickson","doi":"10.1016/j.kint.2025.10.019","DOIUrl":"https://doi.org/10.1016/j.kint.2025.10.019","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"14 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.kint.2026.01.004
Rakesh Verma, Audrey Cleuren, Vania Hinkovska-Galcheva, Ilka Decker, Robert Kelly, David Ginsburg, James A. Shayman
{"title":"Heat shock protein 70s are modifiers of endothelial function in Fabry disease","authors":"Rakesh Verma, Audrey Cleuren, Vania Hinkovska-Galcheva, Ilka Decker, Robert Kelly, David Ginsburg, James A. Shayman","doi":"10.1016/j.kint.2026.01.004","DOIUrl":"https://doi.org/10.1016/j.kint.2026.01.004","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"1 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.kint.2025.09.025
Barry I. Freedman , Barbara S. Gillespie , Ogo I. Egbuna
New International Classification of Disease-10th Edition-Clinical Modification codes for APOL1-mediated kidney disease (AMKD) and family history of AMKD in the United States provide great hope to the millions of people with recent African ancestry and chronic kidney disease worldwide. In the past, vague diagnosis codes forced misclassification of many such patients, especially nondiabetic persons of African ancestry. The lack of an AMKD diagnosis in the US Renal Data System and international registries has had profound effects on public health, confusing the epidemiology of kidney failure and delaying research for more accurate diagnoses and treatments. With these codes, nephrologists and providers caring for patients with and at risk for chronic kidney disease must be vigilant to identify, genotype, and appropriately code patients with AMKD. We owe it to our patients and future generations in their families to detect AMKD at earlier stages. This will permit their enrollment into clinical trials that provide hope for a cure.
{"title":"ICD-10 codes for APOL1-mediated kidney disease","authors":"Barry I. Freedman , Barbara S. Gillespie , Ogo I. Egbuna","doi":"10.1016/j.kint.2025.09.025","DOIUrl":"10.1016/j.kint.2025.09.025","url":null,"abstract":"<div><div>New <em>International Classification of Disease-10th Edition-Clinical Modification</em> codes for <em>APOL1</em>-mediated kidney disease (AMKD) and family history of AMKD in the United States provide great hope to the millions of people with recent African ancestry and chronic kidney disease worldwide. In the past, vague diagnosis codes forced misclassification of many such patients, especially nondiabetic persons of African ancestry. The lack of an AMKD diagnosis in the US Renal Data System and international registries has had profound effects on public health, confusing the epidemiology of kidney failure and delaying research for more accurate diagnoses and treatments. With these codes, nephrologists and providers caring for patients with and at risk for chronic kidney disease must be vigilant to identify, genotype, and appropriately code patients with AMKD. We owe it to our patients and future generations in their families to detect AMKD at earlier stages. This will permit their enrollment into clinical trials that provide hope for a cure.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"109 2","pages":"Pages 238-241"},"PeriodicalIF":12.6,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.kint.2025.11.003
Sabine Karam , Marina Wainstein , Fiona Brown , Rolando Claure-Del Granado , Gavin Dreyer , Miguel Gallardo , Roberto Pecoits-Filho , Jeffrey Perl , Kornchanok Vareesangthip , Bianca Davidson
{"title":"Empowering the next generation for kidney health advancement worldwide: the Young Nephrologists Committee of the International Society of Nephrology","authors":"Sabine Karam , Marina Wainstein , Fiona Brown , Rolando Claure-Del Granado , Gavin Dreyer , Miguel Gallardo , Roberto Pecoits-Filho , Jeffrey Perl , Kornchanok Vareesangthip , Bianca Davidson","doi":"10.1016/j.kint.2025.11.003","DOIUrl":"10.1016/j.kint.2025.11.003","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"109 2","pages":"Pages 248-251"},"PeriodicalIF":12.6,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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