Back Cover: Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling (EXP2 3/2024)

Yumei Que, Jiaxin Shi, Zhaowenbin Zhang, Lu Sun, Hairu Li, Xionghai Qin, Zhen Zeng, Xiao Yang, Yanxin Chen, Chong Liu, Chang Liu, Shijie Sun, Qishu Jin, Yanxin Zhang, Xin Li, Ming Lei, Chen Yang, Hai Tian, Jiawei Tian, Jiang Chang
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Abstract

Ion cocktail consisting of silicate, strontium and copper ions significantly reduces the deteriorative electrical and structural remodeling after myocardial infarction by stimulating angiogenesis of endothelial cells and M2 polarization of macrophages, and inhibiting cardiomyocyte apoptosis under hypoxia/ischemic condition. This ion cocktail therapy reveals a new strategy to effectively treat myocardial infarction with clinical translation potential.

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封底:离子鸡尾酒疗法通过协同调节结构和电重塑治疗心肌梗死(EXP2 3/2024)
由硅酸盐、锶和铜离子组成的离子鸡尾酒通过刺激血管内皮细胞的血管生成和巨噬细胞的M2极化,以及抑制缺氧/缺血状态下心肌细胞的凋亡,显著减轻了心肌梗死后心肌电学和结构重塑的恶化。这种离子鸡尾酒疗法揭示了一种有效治疗心肌梗死的新策略,具有临床转化潜力。
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Issue Information Back Cover: High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption (EXP2 6/2024) Frontispiece: Advancements and challenges in brain cancer therapeutics (EXP2 6/2024) Front Cover: Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages (EXP2 6/2024) Pioneering Exploration for a lasting and sustainable future
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