In vitro and in vivo inhibitory effects of the Sanghuang mushroom extracts against Candida albicans.

IF 2.5 4区生物学 Q3 MICROBIOLOGY Future microbiology Pub Date : 2024-01-01 Epub Date: 2024-06-21 DOI:10.1080/17460913.2024.2352269

Jiahui Du, Shuqing Jin, Ying Zhang, Wei Qiu, Yahui Dong, Yan Liu, Dengke Yin, Ye Yang, Weifang Xu

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Abstract

Aim: To explore the antifungal potential of Sanghuang mushroom, a traditional Chinese medicine. Materials & methods: The antifungal properties and the potential mechanism of Sanghuang mushroom extracts against Candida albicans were studied in vitro and in vivo. Results: Sanghuang mushroom extracts inhibited the biofilm formation, increased the cell membrane permeability and promoted cell apoptosis of C. albicans in vitro. In a murine model of vulvovaginal candidiasis, Sanghuang mushroom extracts reduced the vaginal fungal load, improved inflammatory cell infiltration and downregulated the expression of TNF-α, IL-1β and IL-6. Untargeted metabolomic analysis suggested the presence of ten antifungal components in Sanghuang mushroom extracts. Conclusion: Sanghuang mushroom extracts showed promise as antifungal agent against candidiasis, with potential therapeutic implications.

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三黄菇提取物对白色念珠菌的体外和体内抑制作用。

目的：探索中药三黄菇的抗真菌潜力。材料与方法：在体外和体内研究三黄菇提取物对白色念珠菌的抗真菌特性和潜在机制。结果在体外，三黄菇提取物能抑制白色念珠菌生物膜的形成，增加细胞膜的通透性，促进细胞凋亡。在小鼠外阴阴道念珠菌病模型中，三黄菇提取物降低了阴道真菌负荷，改善了炎症细胞浸润，并下调了 TNF-α、IL-1β 和 IL-6 的表达。非靶向代谢组分析表明，三黄菇提取物中含有十种抗真菌成分。结论三黄菇提取物有望成为抗念珠菌病的抗真菌剂，具有潜在的治疗意义。

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.

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