Community-based intervention for obstructive sleep apnea in the general population: a randomized controlled trial.

IF 5.6 2区医学 Q1 Medicine Sleep Pub Date : 2024-09-09 DOI:10.1093/sleep/zsae132

Longlong Wang, Qiong Ou, Guangliang Shan, Weixin Zhan, Jinhuan Huang, Qiuqiang Lin, Jianfei Li, Yibin Liu, Yuejun Xu, Chunyan Chen, Weili Chen

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Abstract

Study objectives: To investigate the engagement and health outcomes of community-based intervention for obstructive sleep apnea (OSA) in the general population.

Methods: We conducted a 3-month randomized controlled trial in two communities in southern China. We initially screened the general population for high-risk OSA and further diagnosis using home sleep testing. Eligible participants were randomly (1:1) assigned to either a control or continuous positive airway pressure-based integrated intervention group. The primary outcomes were multimodal indicators reflecting health outcomes, including health-related quality of life (Short Form-36 [SF-36]), sleep-related symptoms, and cardiometabolic risk.

Results: Of the 2484 participants screened, 1423 identified as having high-risk OSA were considered for telephone invitations to participate in the trial. Of these, 401 participants responded positively (28.2%), 279 were diagnosed with OSA, and 212 were randomized. The intervention significantly improved several domains of SF-36, including physical functioning (intergroup difference, 2.8; p = .003), vitality (2.3; p = .031), and reported health transition (6.8; p = .005). Sleep-related symptoms, including Epworth Sleepiness Scale (-0.7; p = .017), Fatigue Severity Scale (-3.0; p = .022), Insomnia Severity Index (-1.8; p < .001), and Pittsburgh Sleep Quality Index (-0.7; p = .032), also showed significant improvements. Although the intervention did not significantly alter glycolipid metabolism, ventricular function, or cardiac structural remodeling, it achieved a significant reduction in systolic (-4.5 mmHg; p = .004) and diastolic blood pressure (BP; -3.7 mmHg; p < .001).

Conclusions: Community-based intervention for previously undiagnosed OSA in the general population yielded improvements in health-related quality of life, sleep-related symptoms, and BP. However, engagement in the intervention program was low.

Clinical trial registration: "Community Intervention Trial for OSA";URL: https://www.chictr.org.cn/showprojEN.html?proj=144927;Trial identification number: ChiCTR2100054800.

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基于社区的普通人群阻塞性睡眠呼吸暂停干预：随机对照试验》。

研究目的调查社区阻塞性睡眠呼吸暂停（OSA）干预在普通人群中的参与度和健康结果：我们在中国南方的两个社区开展了为期 3 个月的随机对照试验。我们首先对普通人群进行了高危 OSA 筛查，并通过家庭睡眠测试进行了进一步诊断。符合条件的参与者被随机（1:1）分配到对照组或基于持续气道正压的综合干预组。主要结果是反映健康结果的多模式指标，包括健康相关生活质量（短表-36 [SF-36]）、睡眠相关症状和心脏代谢风险：在接受筛查的 2484 名参与者中，有 1423 人被确定为 OSA 高危人群，他们被考虑通过电话邀请参加试验。其中，401 名参与者做出了积极回应（28.2%），279 人被确诊为 OSA，212 人被随机分配。干预明显改善了 SF-36 的多个领域，包括身体功能（组间差异为 2.8；P=0.003）、活力（2.3；P=0.031）和报告的健康转变（6.8；P=0.005）。与睡眠相关的症状，包括埃普沃思嗜睡量表（-0.7；P=0.017）、疲劳严重程度量表（-3.0；P=0.022）、失眠严重程度指数（-1.8；PConclusions：针对普通人群中之前未确诊的 OSA 进行社区干预后，健康相关生活质量、睡眠相关症状和血压均有所改善。然而，干预计划的参与度较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.