Protonation regulates intermolecular interaction force to achieve reversible ACQ-AIE conversion

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2024-06-20 DOI:10.1016/j.dyepig.2024.112296

Junliang Zhou , Zhiwei Ma , Haiyang Wang , Wen Wang , Kaijin Chen , Hongxing Gui , Zhenguo Chi , Siwei Liu

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Abstract

In recent years, there has been a lot of focus on aggregation-induced emission materials, and most of the research has focused on the unidirectional conversion from ACQ (aggregation-causing quenching) to AIE (aggregation-induced emission), which inevitably requires complex chemical synthesis and cumbersome processes, and molecules with reversible ACQ and AIE conversion characteristics are rarely reported. In order to achieve a reversible conversion based on a single material between ACQ and AIE properties, we have developed a new functional material, DBPZ-2 (1,4-bis((4-(benzo[c] (Li et al., 2020; Hu et al., 2014; Song et al., 2024) [1,2,5]thiadiazol-4-yl)piperazin-1-yl)methyl)benzene). This compound exhibits AIE properties under neutral conditions, and interestingly, it exhibits significant ACQ properties when protonated, and then restores AIE properties after simple deprotonation. Furthermore, the sensitive response of DBPZ-2 to pH can be used as a fluorescent probe to monitor the changes in the pH value of cellular lysosomes, which brings hopes for future research on lysosomal biology and related diseases.

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质子化调节分子间相互作用力，实现 ACQ-AIE 的可逆转换

近年来，聚集诱导发射材料备受关注，大部分研究集中在从ACQ（聚集致淬灭）到AIE（聚集诱导发射）的单向转换上，这不可避免地需要复杂的化学合成和繁琐的工艺，而具有ACQ和AIE可逆转换特性的分子鲜有报道。为了实现基于单一材料的 ACQ 和 AIE 特性之间的可逆转换，我们开发了一种新的功能材料 DBPZ-2 （1,4-双（（4-(苯并[c] (Li et al., 2020; Hu et al., 2014; Song et al., 2024) [1,2,5]thiadiazol-4-yl)piperazin-1-yl)methyl)benzene ）。这种化合物在中性条件下表现出 AIE 特性，有趣的是，它在质子化时表现出显著的 ACQ 特性，简单去质子化后又恢复了 AIE 特性。此外，DBPZ-2 对 pH 值的灵敏反应可用作荧光探针，监测细胞溶酶体 pH 值的变化，这为今后研究溶酶体生物学及相关疾病带来了希望。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.