Dyes and Pigments最新文献

Development of a novel dual fluorescent probe: mitochondrial targeting and iron chelator 一种新型双荧光探针：线粒体靶向和铁螯合剂的研制

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-07-01 Epub Date: 2026-02-12 DOI: 10.1016/j.dyepig.2026.113644

Camilo Segura , Osvaldo Yañez , Pamela J. Urrutia , Pabla Aguirre , María Quilaqueo , Marco T. Núñez , Juan Hinestroza , Margarita Aliaga , Ramón Martínez-Máñez , Olimpo García-Beltrán

We report the design, synthesis, and characterization of YBL-1, a coumarin–triphenylphosphonium (TPP⁺) fluorescent probe engineered for mitochondrial targeting and iron sensing. YBL-1 was obtained through a three-step sequence culminating in quaternization with (bromomethyl)triphenylphosphonium bromide. Steady-state photophysics reveal minimal solvatochromism (λ_abs 348–355 nm; λ_em 401–408 nm) and allowed transitions (ε_max ≈ 2.2–2.6 × 10⁴ M⁻¹ cm⁻¹). The probe remains bright in water, with high quantum yields (Φ_F ≈ 0.76). Screening against common metal cations indicates a pronounced and selective turn-off response to Fe³⁺. Job's analysis supports 1:1 complexation, and Benesi–Hildebrand treatment (1:1 model) indicates a modest association constant on the order of 10² M⁻¹ in water. Complementary quantum-chemical calculations support a predominantly π→π∗ locally excited S₁ state with only weak charge-transfer character, consistent with the small solvatochromism. Electrostatic potential maps and population analyses highlight the carbonyl/urea/alkoxy region as the primary hard-donor site, rationalizing Fe³⁺ binding; simple adduct models in water predict modest stabilization in line with the measured Ka and a rigidified complex consistent with static quenching. In SH-SY5Y cells co-stained with MitoTracker Red, YBL-1 colocalizes strongly with mitochondria (Pearson r ≈ 0.95), consistent with TPP⁺-driven membrane-potential-mediated accumulation. Complementary computations (DFT/MEP) indicate robust electrostatic features and preferential stabilization in polar media, with the lowest relative energy in water. Together, these results establish YBL-1 as a water-bright, mitochondria-addressable fluorescent probe exhibiting selective Fe³⁺-responsive quenching suitable for live-cell imaging.

我们报道了一种用于线粒体靶向和铁传感的香豆素-三苯磷（TPP+）荧光探针YBL-1的设计、合成和表征。YBL-1是通过与（溴甲基）三苯基溴化磷进行季铵化的三步反应得到的。稳态光物理显示最小的溶剂变色（λabs 348 - 355nm; λem 401 - 408nm）和允许的跃迁（εmax≈2.2-2.6 × 104 M−1 cm−1）。探针在水中保持明亮，具有高量子产率（ΦF≈0.76）。对常见金属阳离子的筛选表明对Fe3+有明显的选择性关闭反应。Job的分析支持1:1络合，而Benesi-Hildebrand处理（1:1模型）表明，水中的适度关联常数约为102 M−1。互补量子化学计算支持以π→π *为主的局部激发S1态，只有弱的电荷转移特征，与小溶剂变色相一致。静电电位图和种群分析强调羰基/尿素/烷氧基区域是主要的硬供体位点，使Fe3+结合合理化；水中的简单加合物模型预测适度的稳定与测量的Ka一致，刚性配合物与静态淬火一致。在与MitoTracker Red共染色的SH-SY5Y细胞中，ybl1与线粒体强共定位（Pearson r≈0.95），与TPP+驱动的膜电位介导的积累一致。互补计算（DFT/MEP）表明极性介质具有强大的静电特性和优先稳定性，在水中的相对能量最低。总之，这些结果表明YBL-1是一种水亮、线粒体可寻位的荧光探针，具有选择性的Fe3+响应猝灭，适合于活细胞成像。

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引用次数: 0

A novel N-heterocyclic AIEgen for highly selective ATP sensing and visual bacterial detection in beverages 一种新型n -杂环AIEgen用于高选择性ATP传感和饮料中细菌的视觉检测

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-07-01 Epub Date: 2026-02-12 DOI: 10.1016/j.dyepig.2026.113642

Wenlong Xing , Yin Zhu , Jiahao Wu , Shijia Li , Zhenyu Zhao , Jinsong Zhang , Shaowei Bo , Ji Zeng , Jiangling Peng

The rapid and accurate detection of adenosine 5′-triphosphate (ATP) is crucial for clinical diagnostics, bioanalysis, and food safety. This study presents two novel aggregation-induced emission (AIE)-active probes, BIP-PP-1 and BIP-PP-2, derived from a new N-heterocyclic AIEgen core, benzo[4,5]imidazo[1,2-c]pyrimidine (BIP). The optimized probe, BIP-PP-2, functions as a high-performance ATP sensor with a large Stokes shift, high sensitivity (LOD = 0.85 μM, linear range 0 – 90 μM), and excellent selectivity over structurally similar anions such as ADP, AMP, CTP, TTP, and UTP, a feature seldom achieved in small-molecule ATP probes. This unique selectivity is attributed to the novel BIP core, where specific π-π stacking and hydrogen-bonding interactions with the adenine moiety of ATP provide a superior stereoelectronic match, driving precise recognition and AIE-based fluorescence enhancement via a synergistic combination of electrostatic and non-covalent forces. BIP-PP-2 was successfully applied in real-time ATP imaging within live bacterial cells and, notably, in the rapid visual detection of bacterial contamination in beverages using a portable 365 nm UV lamp, achieving a visual detection limit of 3.9 × 10⁵ CFU mL⁻¹ under ambient light. This work introduces the BIP scaffold as a promising platform for functional dye design and establishes BIP-PP-2 as a robust analytical tool for on-site bioanalysis and food safety monitoring. © 2001 Elsevier Science. All rights reserved.

快速准确地检测5 ' -三磷酸腺苷（ATP）对临床诊断、生物分析和食品安全至关重要。本研究提出了两种新的聚集诱导发射（AIE）活性探针，BIP- pp -1和BIP- pp -2，它们来源于一种新的n-杂环AIEgen核心，苯并[4,5]咪唑[1,2-c]嘧啶（BIP）。优化后的探针BIP-PP-2是一种高性能的ATP传感器，具有大Stokes位移、高灵敏度（LOD = 0.85 μM，线性范围0 - 90 μM）和对结构相似的阴离子（如ADP、AMP、CTP、TTP和UTP）的优异选择性，这是小分子ATP探针很少实现的特性。这种独特的选择性归因于新的BIP核心，其中特定的π-π堆叠和与ATP腺嘌呤部分的氢键相互作用提供了优越的立体电子匹配，通过静电和非共价力的协同组合驱动精确识别和基于ai的荧光增强。BIP-PP-2成功地应用于活细菌细胞内的实时ATP成像，特别是在使用便携式365 nm紫外灯对饮料中的细菌污染进行快速视觉检测中，在环境光下的视觉检测限为3.9 × 105 CFU mL−1。这项工作介绍了BIP支架作为功能性染料设计的一个有前途的平台，并建立了BIP- pp -2作为现场生物分析和食品安全监测的强大分析工具。©2001爱思唯尔科学版权所有。

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引用次数: 0

Recent progress of Si-rhodamine-based probes in intracellular imaging of metal ions and small molecules 硅罗丹明基探针在金属离子和小分子细胞内成像中的最新进展

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-07-01 Epub Date: 2026-02-12 DOI: 10.1016/j.dyepig.2026.113643

Yunjia Xu , Xiaofei Tian , Qi Ai , Baoxiang Gao

Si-rhodamines exhibit exceptional photostability and tunable near-infrared emission wavelengths, rendering them highly versatile tools for bioimaging applications—including cellular imaging, super-resolution imaging, in vivo imaging, and the detection of biological small molecules. Driven by the growing interest in Si-rhodamine-based probes and their significant potential for intracellular imaging of metal ions and small molecules, herein we systematically summarize the remarkable advancements in Si-rhodamine-derived fluorescent probes for this purpose. By elaborating on the design principles, reaction mechanisms, and biological applications of probes targeting a broad spectrum of analytes, encompassing metal ions (e.g., Mg²⁺, Ca²⁺, Cu⁺, Cu²⁺, Hg²⁺, Zn²⁺) and small molecules (e.g., HOCl, NO, formaldehyde, H₂S), we delineate how the superior photophysical properties of the Si-rhodamine scaffold underpin their robust performance in intracellular sensing. Furthermore, this review discusses key remaining challenges in the field and highlights promising future opportunities, providing valuable insights to guide subsequent research endeavors in the development of advanced Si-rhodamine-based imaging tools.

si -罗丹明具有优异的光稳定性和可调的近红外发射波长，使其成为生物成像应用的高度通用工具，包括细胞成像、超分辨率成像、体内成像和生物小分子检测。由于人们对基于硅罗丹明的探针越来越感兴趣，以及它们在金属离子和小分子的细胞内成像方面的巨大潜力，我们在这里系统地总结了硅罗丹明衍生的荧光探针在这方面的显著进展。通过详细阐述探针的设计原理、反应机制和生物应用，针对广泛的分析物，包括金属离子（如Mg2+、Ca2+、Cu+、Cu2+、Hg2+、Zn2+）和小分子（如HOCl、NO、甲醛、H2S），我们描述了si -罗丹明支架优越的光物理特性如何支撑其在细胞内传感中的强大性能。此外，本综述讨论了该领域的关键挑战，并强调了有希望的未来机会，为指导后续开发先进的si -罗丹明成像工具的研究工作提供了有价值的见解。

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引用次数: 0

Nanocoordinated Zn-Baicalein: Merging triple mechanisms with photothermal action for enhanced bacterial eradication 纳米配位锌-黄芩苷：融合三重机制与光热作用增强细菌根除

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-07-01 Epub Date: 2026-02-10 DOI: 10.1016/j.dyepig.2026.113641

Xuemei Sun, Jiahao Li, Suyu Jiang, Lin Zang, Rong-Mei Kong, Yan Zhao, Weiheng Kong

The escalating incidence of antibacterial resistance presents a formidable challenge in managing bacterial infections. Traditional Zn-based antibacterial agents face limitations due to their reliance on ultraviolet activation and potential neurotoxicity. The combination of nanotechnology and traditional Chinese medicine (TCM) not only reduces the side effects of Zn²⁺ but also enhances therapeutic efficacy. In this study, we synthesized Zn-baicalein nanoparticles (Zn-BE NPs) that self-assemble through chemical coordination, offering broad-spectrum antibacterial capabilities. The Zn component exhibited inherent antibacterial properties by disrupting the synthesis of bacterial metabolic enzymes and destroying genetic factors. Baicalein (BE), derived from Scutellaria, enhanced the NPs’ antibacterial efficacy by disrupting bacterial membranes and facilitating Zn²⁺ influx, leading to cell wall rupture and metabolic disruption. In addition, Zn-BE NPs exhibited excellent photothermal conversion efficiency, enabling effective bactericidal action under near-infrared irradiation. This triple synergistic mechanism not only overcame the limitations of conventional Zn-based therapies but also sustained long-term antibacterial activity by preventing rapid bacterial metabolism. Our findings demonstrated that Zn-BE NPs could achieve complete bacterial eradication, showcasing expected potential in addressing antibacterial resistance. This research laid a foundation for the development of safer and more effective antibacterial agents, with implications for future applications in combating resistant infections.

抗菌药物耐药性的不断上升对细菌感染的管理提出了严峻的挑战。传统的锌基抗菌剂由于依赖紫外线激活和潜在的神经毒性而面临局限性。纳米技术与中药的结合不仅可以减少Zn2+的副作用，而且可以提高治疗效果。在这项研究中，我们合成了通过化学配位自组装的锌-黄芩素纳米粒子（Zn-BE NPs），具有广谱抗菌能力。锌组分通过破坏细菌代谢酶的合成和破坏遗传因子表现出固有的抗菌特性。黄芩苷（Baicalein， BE）通过破坏细菌膜，促进Zn2+内流，导致细胞壁破裂和代谢紊乱，从而增强NPs的抗菌作用。此外，Zn-BE NPs表现出优异的光热转换效率，在近红外照射下具有有效的杀菌作用。这种三重协同机制不仅克服了传统锌基治疗的局限性，而且通过防止细菌快速代谢而保持长期的抗菌活性。我们的研究结果表明，Zn-BE NPs可以完全根除细菌，显示出解决抗菌耐药性的预期潜力。该研究为开发更安全、更有效的抗菌剂奠定了基础，对今后在抗耐药感染方面的应用具有重要意义。

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引用次数: 0

Pure-green top-emitting organic light-emitting diodes toward REC.2020 standard with ultra-narrow full-width at half-maximum 纯绿色顶光有机发光二极管，符合REC.2020标准，半最大全宽超窄

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-07-01 Epub Date: 2026-02-10 DOI: 10.1016/j.dyepig.2026.113636

Yuhang Que , Haoran Yang , Guodong Sun , Xiaoyang Xia , Liang Zhou , Li Wang

Thermally activated delayed fluorescence (TADF) materials facilitate reverse intersystem crossing (RISC) by enhancing the intramolecular charge transfer (ICT) process, thereby increasing exciton utilization and significantly improving the efficiency of organic light-emitting diodes (OLEDs). However, the ICT process also results in considerable spectral broadening and diminished color purity in the devices. Here, a top-emission structure is employed to narrow the emission spectrum and improve the light extraction rate. The experimental results reveal that the full-width at half-maximum (FWHM) and color purity based on the first-order microcavity device are significantly optimized compared with the bottom-emitting organic light-emitting diodes (BE-OLEDs). The FWHM decreases from 93 to 33 nm with the external quantum efficiency (EQE) significantly increasing by 61%, indicating superior device efficiency. The FWHM of second-order microcavity devices is further reduced to 21 nm, achieving Commission Internationale de l'Eclairage coordinates of (0.164, 0.761), which is very close to the REC.2020 standard. Our strategy is simple and can significantly improve color purity of the prepared devices, which promotes the applications of OLEDs in high-gamut displays.

热激活延迟荧光（TADF）材料通过增强分子内电荷转移（ICT）过程促进反向系统间交叉（RISC），从而增加激子利用率，显著提高有机发光二极管（oled）的效率。然而，ICT工艺也会导致器件中的光谱展宽和颜色纯度降低。本文采用顶发射结构来缩小发射光谱，提高光提取率。实验结果表明，与底发光有机发光二极管（be - oled）相比，基于一阶微腔器件的半最大值全宽度（FWHM）和颜色纯度显著优化。FWHM从93 nm减小到33 nm，外量子效率（EQE）显著提高61%，表明器件效率较高。二阶微腔器件的FWHM进一步减小到21 nm，达到国际eclairage委员会坐标（0.164,0.761），非常接近REC.2020标准。我们的策略简单，可以显著提高所制备器件的颜色纯度，从而促进oled在高色域显示中的应用。

{"title":"Pure-green top-emitting organic light-emitting diodes toward REC.2020 standard with ultra-narrow full-width at half-maximum","authors":"Yuhang Que , Haoran Yang , Guodong Sun , Xiaoyang Xia , Liang Zhou , Li Wang","doi":"10.1016/j.dyepig.2026.113636","DOIUrl":"10.1016/j.dyepig.2026.113636","url":null,"abstract":"<div><div>Thermally activated delayed fluorescence (TADF) materials facilitate reverse intersystem crossing (RISC) by enhancing the intramolecular charge transfer (ICT) process, thereby increasing exciton utilization and significantly improving the efficiency of organic light-emitting diodes (OLEDs). However, the ICT process also results in considerable spectral broadening and diminished color purity in the devices. Here, a top-emission structure is employed to narrow the emission spectrum and improve the light extraction rate. The experimental results reveal that the full-width at half-maximum (FWHM) and color purity based on the first-order microcavity device are significantly optimized compared with the bottom-emitting organic light-emitting diodes (BE-OLEDs). The FWHM decreases from 93 to 33 nm with the external quantum efficiency (EQE) significantly increasing by 61%, indicating superior device efficiency. The FWHM of second-order microcavity devices is further reduced to 21 nm, achieving Commission Internationale de l'Eclairage coordinates of (0.164, 0.761), which is very close to the REC.2020 standard. Our strategy is simple and can significantly improve color purity of the prepared devices, which promotes the applications of OLEDs in high-gamut displays.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"250 ","pages":"Article 113636"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146161975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance PM567-doped PMMA/E7 composites random lasers enabled by periodically patterned sapphire substrates for speckle-free imaging 高性能掺pm567的PMMA/E7复合材料通过周期性图案蓝宝石衬底实现无斑点成像的随机激光器

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-06-01 Epub Date: 2026-02-09 DOI: 10.1016/j.dyepig.2026.113638

Tianwei Song , Jiarong Zhang , Zihui Ran , Caixia Xu , Zhengguo Xiao , Liu Wu , Long Xu

Dye-doped polymer liquid crystal (DD-PDLC) random lasers have exhibited promising potential in speckle-free laser imaging, non-polarized flexible displays, biological research, and optical sensing due to their unique features of low spatial coherence, multi-wavelength laser emission, and omnidirectional light output. However, challenges such as high lasing thresholds, poor film uniformity, and insufficient stability persist, primarily arising from fluorescence quenching and dye aggregation-induced gain reduction, photobleaching under prolonged excitation, and inadequate control over liquid crystal alignment and polymer network structures, which lead to unstable light scattering in pure liquid crystal systems. This study demonstrates a systematic optimization strategy for random lasers in PM567 doped poly (methyl methacrylate) (PMMA)/E7 liquid crystal composites, incorporating a patterned sapphire substrate (PSS) with periodic microstructures to enhance feedback efficiency, achieving a quality factor of 2846, a narrow linewidth of approximately 0.2 nm, and a remarkably low threshold of 0.52 mJ/cm². As a speckle-free random laser source, it exhibits a signal-to-noise ratio (SNR) of 23.37, showing a 16-fold improvement over pumped pulsed lasers (SNR = 1.41) and a 5-fold enhancement compared to white light sources (SNR = 4.57). These advancements have paved the way for the practical application of random lasers in high-resolution speckle-free bioimaging and next-generation optoelectronic devices.

染料掺杂聚合物液晶（DD-PDLC）随机激光器由于具有低空间相干性、多波长激光发射和全向光输出等特点，在无散斑激光成像、非偏振柔性显示、生物研究和光学传感等领域具有广阔的应用前景。然而，诸如高激光阈值、薄膜均匀性差和稳定性不足等挑战仍然存在，主要是由于荧光猝灭和染料聚集引起的增益降低，长时间激发下的光漂白，以及对液晶排列和聚合物网络结构的控制不足，导致纯液晶系统中的光散射不稳定。本研究展示了PM567掺杂聚甲基丙烯酸甲酯(PMMA)/E7液晶复合材料中随机激光器的系统优化策略，结合具有周期性微结构的图案蓝宝石衬底（PSS）来提高反馈效率，实现了质量因子2846，线宽约0.2 nm，阈值为0.52 mJ/cm2的显著低阈值。作为无斑点的随机激光源，它的信噪比（SNR）为23.37，比泵浦脉冲激光器（SNR = 1.41）提高了16倍，比白光光源（SNR = 4.57）提高了5倍。这些进步为随机激光器在高分辨率无散斑生物成像和下一代光电器件中的实际应用铺平了道路。

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引用次数: 0

Investigating fluorination effects in a perylene diimide trimer for organic solar cells 研究有机太阳能电池用苝二亚胺三聚体的氟化效应

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.dyepig.2026.113621

Yanjie Sun , Yuheng Ni , Ruize Zhou , Zhenye Wang , Xiang Gao , Xiaoling Ma , Jianhong Gao , Hui Chen , Fujun Zhang , Zhitian Liu

Three-dimensional (3D) perylene diimide (PDI) oligomers effectively suppress the excessive aggregation inherent to PDI monomers, yet their photovoltaic performance is often hampered by low electron mobility resulting from the distorted molecular structure. In this work, a new fluorinated PDI trimer (F-PDI3) was synthesized, alongside its non-fluorinated analogue (Ph-PDI) for comparative analysis. The F-PDI3 based device exhibited an electron mobility of 7.62 × 10⁻⁴ cm² V⁻¹ s⁻¹, which is 1.5 times higher than that of Ph-PDI based device (5.07 × 10⁻⁴ cm² V⁻¹ s⁻¹). This enhanced electron mobility, along with more favorable morphology contributed to enhanced charge generation and suppressed recombination. As a result, the PM6:F-PDI3 OSCs achieved a superior PCE value of 8.29 %, ranking among the top-performing PDI-based OSCs. This study demonstrates that fluorination as a potent strategy for enhancing the electron mobility of 3D PDI acceptor materials, thus improves their photovoltaic performance.

三维（3D）苝二亚胺（PDI）低聚物有效抑制了PDI单体固有的过度聚集，但由于扭曲的分子结构导致的电子迁移率低，往往阻碍了它们的光伏性能。本文合成了一种新的氟化PDI三聚体（F-PDI3），并与其非氟化类似物（Ph-PDI）进行了比较分析。基于F-PDI3的器件的电子迁移率为7.62 × 10−4 cm2 V−1 s−1，是基于Ph-PDI器件（5.07 × 10−4 cm2 V−1 s−1）的1.5倍。这种增强的电子迁移率，以及更有利的形态有助于增强电荷产生和抑制重组。结果表明，PM6:F-PDI3 OSCs的PCE值为8.29%，在基于pdi的OSCs中名列前茅。本研究表明，氟化作为一种有效的策略，可以提高3D PDI受体材料的电子迁移率，从而提高其光伏性能。

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引用次数: 0

Design and application of β-gal fluorescent probes in cancer imaging: A review β-gal荧光探针在肿瘤成像中的设计与应用综述

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.dyepig.2026.113608

Muhanad Alhujaily , Alaa Shafie

Beta-galactosidase (β-Gal) has emerged as a clinically relevant biomarker in oncology due to its elevated activity in multiple tumor types and its strong association with cellular senescence, lysosomal alterations, and therapy-induced stress responses. The ability to detect β-Gal activity with high sensitivity offers unique opportunities for early cancer diagnosis, real-time tumor visualization, and monitoring therapeutic outcomes. In recent years, fluorescent probes responsive to β-Gal have rapidly evolved as powerful molecular imaging tools, supported by advances in fluorophore engineering, enzyme-triggered activation strategies, and in vivo imaging technologies. These probes typically operate on mechanisms such as enzymatic cleavage of β-Gal, intramolecular charge transfer (ICT), aggregation-induced emission (AIE), photoinduced electron transfer (PET), excited-state intramolecular proton transfer (ESIPT) and near-infrared signaling platforms. Such designs allow high specificity, low background interference, deep-tissue penetration, and dynamic measurement of β-Gal activity in complex biological environments. This review provides a comprehensive overview of recent progress in the design and biomedical application of β-Gal-responsive fluorescent probes for cancer imaging. Key classes of fluorophores are discussed with regard to structural features, photophysical behavior, and responsiveness to enzymatic activation. Special emphasis is placed on innovations enabling turn-on, ratiometric, and two-photon imaging, as well as emerging strategies that leverage renal-clearable probes and activatable near-infrared (NIR) systems for tumor detection with high precision. Furthermore, the review highlights representative applications across cancer models, demonstrating the utility of β-Gal-activatable probes for distinguishing malignant from normal tissues, mapping tumor heterogeneity, visualizing senescent cancer cells, and evaluating therapeutic efficacy.

由于β-半乳糖苷酶（β-Gal）在多种肿瘤类型中的活性升高，并且与细胞衰老、溶酶体改变和治疗诱导的应激反应密切相关，因此β-半乳糖苷酶（β-Gal）已成为肿瘤学临床相关的生物标志物。高灵敏度检测β-Gal活性的能力为早期癌症诊断、实时肿瘤可视化和监测治疗结果提供了独特的机会。近年来，在荧光团工程、酶触发激活策略和体内成像技术的进步支持下，响应β-Gal的荧光探针迅速发展成为强大的分子成像工具。这些探针通常作用于酶促β-Gal裂解、分子内电荷转移（ICT）、聚集诱导发射（AIE）、光诱导电子转移（PET）、激发态分子内质子转移（ESIPT）和近红外信号平台等机制。这种设计允许高特异性，低背景干扰，深层组织穿透，并在复杂的生物环境中动态测量β-Gal活性。本文综述了β- gal反应性荧光探针在肿瘤成像中的设计和生物医学应用方面的最新进展。主要种类的荧光基团讨论了结构特征，光物理行为，和响应酶的活化。特别强调的是启用开启、比率成像和双光子成像的创新，以及利用肾脏清除探针和可激活的近红外（NIR）系统进行高精度肿瘤检测的新兴策略。此外，该综述强调了在癌症模型中的代表性应用，证明了β- gal激活探针在区分恶性组织和正常组织、绘制肿瘤异质性、观察衰老癌细胞和评估治疗效果方面的效用。

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引用次数: 0

Dual-state emission fluorescent probe based on 2,7-naphthyridine for visualization of third-level details in fingerprints 基于2,7-萘啶的双态发射荧光探针用于指纹三级细节的可视化

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.dyepig.2026.113601

Yin-Si Sun , Sai-Ping Geng , Si-Jun Zhen , Lv-Xi Qu , Neng-Fang She

Latent fingerprints (LFPs) play a crucial role in forensic identification. However, conventional detection methods often face challenges such as low contrast and toxicity. Existing fluorescent probes also have certain limitations, including aggregation-caused quenching (ACQ). The use of molecules exhibiting dual-state emission (DSE) properties offers a promising solution to these issues. In this study, we designed and synthesized three DSE fluorescent derivatives—NDTPA, NDSF, and NDPH—based on 2,7-naphthyridine and triphenylamine (TPA) to overcome these challenges. These derivatives exhibit excellent DSE properties. The introduction of diverse π-bridge structures effectively modulates their luminescence, thereby minimizing interference from complex background colors and ensuring optimal detection performance across various colored substrates. Using montmorillonite (MMT) as a matrix, composite powders (NDTPA-MMT, NDSF-MMT, and NDPH-MMT) were prepared for LFP imaging. These composites enable rapid and highly sensitive visualization of fingerprints on a wide range of substrates, including tin foil, glass, plastic, wood, coins, CD, ceramic and leather. They reveal features up to Level III (sweat pores) with exceptionally high contrast. In addition, the composite powders offer several advantages, including low cost, simple preparation, and convenient storage. These attributes present a promising strategy for high-resolution latent fingerprint detection and hold broad potential for forensic applications.

潜在指纹在司法鉴定中起着至关重要的作用。然而，传统的检测方法经常面临对比度低和毒性等挑战。现有的荧光探针也有一定的局限性，包括聚集引起的猝灭（ACQ）。使用具有双态发射（DSE）特性的分子为解决这些问题提供了一个有希望的解决方案。在本研究中，我们设计并合成了三种基于2,7-萘吡啶和三苯胺（TPA）的DSE荧光衍生物ndtpa、NDSF和ndph来克服这些挑战。这些衍生物具有优异的DSE性能。各种π桥结构的引入有效地调制了它们的发光，从而最大限度地减少了复杂背景颜色的干扰，确保了在各种颜色衬底上的最佳检测性能。以蒙脱土（MMT）为基体，制备了用于LFP成像的复合粉体（NDTPA-MMT、NDSF-MMT和NDPH-MMT）。这些复合材料能够在各种基材上快速、高灵敏度地可视化指纹，包括锡箔、玻璃、塑料、木材、硬币、CD、陶瓷和皮革。它们以异常高的对比度显示了III级（汗孔）的特征。此外，该复合粉末具有成本低、制备简单、储存方便等优点。这些属性为高分辨率潜在指纹检测提供了一种有前途的策略，并在法医应用中具有广泛的潜力。

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引用次数: 0

A hypoxia-responsive prodrug for specific drug release and synergistic chemo-photodynamic cancer therapy 一种缺氧反应前药，用于特异性药物释放和协同化学-光动力癌症治疗

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments

Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.dyepig.2026.113602

Zhen-Kun Sun , Feng-Yan Yao , Wen-Qiang Wu , Yong-Jun Tao , Tian-Jiao Gao , Jian-Yong Liu , Lijing Zheng

Hypoxia within solid tumors significantly impairs the efficacy of photodynamic therapy (PDT), which relies on oxygen to generate cytotoxic reactive oxygen species (ROS). In this study, we turn this limitation into a therapeutic advantage by developing a hypoxia-activatable prodrug, BAP, which integrates a boron dipyrromethene (BODIPY)-based photosensitizer with paclitaxel (PTX) via a reductively cleavable azobenzene linker. Upon light irradiation, this photosensitizing prodrug mediates photodynamic action that consumes local oxygen, thereby aggravating tumor hypoxia. This heightened hypoxic state facilitates rapid cleavage of the azobenzene linker, resulting in the release of PTX specifically within tumors. As a consequence, tumor cells that survive PDT are effectively eliminated. Both in vitro and in vivo evaluations demonstrated the superior antitumor performance of BAP, which operates through a synergistic mechanism combining BODIPY-driven PDT and hypoxia-triggered chemotherapy. This study presents a novel strategy that not only addresses the challenge of hypoxia in PDT but also leverages it to achieve controlled combination therapy, offering a promising platform for synergistic cancer treatment.

实体瘤内缺氧会显著损害光动力治疗（PDT）的疗效，光动力治疗依赖于氧气产生细胞毒性活性氧（ROS）。在这项研究中，我们通过开发一种可缺氧激活的前药BAP，将这一局限性转化为治疗优势，BAP通过还原可切割的偶氮苯连接剂将基于硼二吡啶（BODIPY）的光敏剂与紫杉醇（PTX）结合。在光照射下，这种光敏前药介导光动力作用，消耗局部氧气，从而加重肿瘤缺氧。这种高缺氧状态促进了偶氮苯连接体的快速裂解，导致PTX在肿瘤内特异性释放。因此，在PDT中存活的肿瘤细胞被有效地消灭。体外和体内评价均表明BAP具有较好的抗肿瘤性能，其作用机制是由bodipy驱动的PDT和缺氧触发的化疗相结合的协同机制。本研究提出了一种新的策略，不仅解决了PDT中缺氧的挑战，而且利用它来实现控制联合治疗，为协同癌症治疗提供了一个有希望的平台。

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