Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 and venous thromboembolism

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-06-22 DOI:10.1016/j.cyto.2024.156682

Ling Zhang, Jing Qin, Peiwu Li

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Abstract

Background

A growing body of research has shown that patients with coronavirus disease 2019 (COVID-19) have significantly higher rates of venous thromboembolism (VTE) than healthy. However, the mechanism remains incompletely elucidated. This study aimed to further investigate the molecular mechanisms underlying the development of this complication.

Methods

The gene expression profiles of COVID-19 and VTE were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the common differentially expressed genes (DEGs) for COVID-19 and VTE, functional annotation, a protein–protein interactions (PPI) network, module construction, and hub gene identification were performed. Finally, we constructed a transcription factor (TF)-gene regulatory network and a TF-miRNA regulatory network for hub genes.

Results

A total of 42 common DEGs were selected for subsequent analyses. Functional analyses showed that biological function and signaling pathways collectively participated in the development and progression of VTE and COVID-19. Finally, 8 significant hub genes were identified using the cytoHubba plugin, including RSL24D1, RPS17, RPS27, HINT1, COX7C, RPL35, RPL34, and NDUFA4, which had preferable values as diagnostic markers for COVID-19 and VTE.

Conclusions

Our study revealed the common pathogenesis of COVID-19 and VTE. These common pathways and pivotal genes may provide new ideas for further mechanistic studies.

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对 COVID-19 和静脉血栓栓塞潜在共同致病机制的生物信息学分析。

背景：越来越多的研究表明，2019 年冠状病毒病（COVID-19）患者的静脉血栓栓塞症（VTE）发病率明显高于健康人。然而，其机制仍未完全阐明。本研究旨在进一步探究这一并发症发生的分子机制：方法：从基因表达总库（GEO）数据库下载 COVID-19 和 VTE 的基因表达谱。在确定了COVID-19和VTE的常见差异表达基因（DEGs）后，我们进行了功能注释、蛋白-蛋白相互作用（PPI）网络、模块构建和枢纽基因鉴定。最后，我们为枢纽基因构建了转录因子（TF）-基因调控网络和TF-miRNA调控网络：结果：共有 42 个常见 DEGs 被选中进行后续分析。功能分析显示，生物功能和信号通路共同参与了 VTE 和 COVID-19 的发生和发展。最后，利用cytoHubba插件确定了8个重要的枢纽基因，包括RSL24D1、RPS17、RPS27、HINT1、COX7C、RPL35、RPL34和NDUFA4，这些基因作为COVID-19和VTE的诊断标志物具有较好的价值：结论：我们的研究揭示了 COVID-19 和 VTE 的共同发病机制。结论：我们的研究揭示了 COVID-19 和 VTE 的共同发病机制，这些共同途径和关键基因可能为进一步的机理研究提供了新思路。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.