The role of mitochondrial dysfunction in kidney injury and disease

IF 9.2 1区 医学 Q1 IMMUNOLOGY Autoimmunity reviews Pub Date : 2024-06-01 DOI:10.1016/j.autrev.2024.103576
Xueqian Jia , Lifu Zhu , Qixing Zhu , Jiaxiang Zhang
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Abstract

Mitochondria are the main sites of aerobic respiration in the cell and mainly provide energy for the organism, and play key roles in adenosine triphosphate (ATP) synthesis, metabolic regulation, and cell differentiation and death. Mitochondrial dysfunction has been identified as a contributing factor to a variety of diseases. The kidney is rich in mitochondria to meet energy needs, and stable mitochondrial structure and function are essential for normal kidney function. Recently, many studies have shown a link between mitochondrial dysfunction and kidney disease, maintaining mitochondrial homeostasis has become an important target for kidney therapy. In this review, we integrate the role of mitochondrial dysfunction in different kidney diseases, and specifically elaborate the mechanism of mitochondrial reactive oxygen species (mtROS), autophagy and ferroptosis involved in the occurrence and development of kidney diseases, providing insights for improved treatment of kidney diseases.

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线粒体功能障碍在肾脏损伤和疾病中的作用。
线粒体是细胞内有氧呼吸的主要场所,主要为生物体提供能量,在三磷酸腺苷(ATP)合成、新陈代谢调节、细胞分化和死亡等方面发挥着关键作用。线粒体功能障碍已被确认为多种疾病的诱因之一。肾脏中含有丰富的线粒体以满足能量需求,稳定的线粒体结构和功能对肾脏的正常功能至关重要。最近,许多研究表明线粒体功能障碍与肾脏疾病之间存在联系,维持线粒体平衡已成为肾脏治疗的一个重要靶点。在这篇综述中,我们整合了线粒体功能障碍在不同肾脏疾病中的作用,并具体阐述了线粒体活性氧(mtROS)、自噬和铁蛋白沉积参与肾脏疾病发生和发展的机制,为改善肾脏疾病的治疗提供启示。
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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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