Electrochemical detection of nalbuphine drug using oval-like ZnO nanostructure-based sensor

IF 2.6 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS Analytical biochemistry Pub Date : 2024-06-21 DOI:10.1016/j.ab.2024.115595

Kanwal Hussain , Rafiq Ahmad , Sohail Hassan , Muhammad Y. Khan , Akil Ahmad , Mohammed B. Alshammari , Muhammad S. Ali , Saeed A. Lakho , Byeong-Il Lee

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Abstract

Monitoring pharmaceutical drugs in various mediums is crucial to mitigate adverse effects. This study presents a chemical sensor using an oval-like zinc oxide (ZnO) nanostructure for electrochemical detection of nalbuphine. The ZnO nanostructure, produced via an efficient sol-gel technique, was extensively characterized using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), UV–visible spectrophotometry, and fourier transform infrared spectroscopy (FTIR). A slurry of the ZnO nanostructure in a binder was applied to a glassy carbon electrode (GCE). The sensor's responsiveness to nalbuphine was assessed using linear sweep voltammetry (LSV), achieving optimal performance by fine-tuning the pH. The sensor demonstrated a proportional response to nalbuphine concentrations up to 150.0 nM with a good regression coefficient (R²) and a detection limit of 6.20 nM (S/N ratio of 3). Selectivity was validated against various interfering substances, and efficacy was confirmed through real sample analysis, highlighting the sensor's successful application for nalbuphine detection.

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利用基于椭圆形氧化锌纳米结构的传感器对纳布啡药物进行电化学检测

监测各种介质中的药物对减轻不良反应至关重要。本研究介绍了一种使用椭圆形氧化锌（ZnO）纳米结构的化学传感器，用于纳布啡的电化学检测。通过高效的溶胶-凝胶技术制备的氧化锌纳米结构使用场发射扫描电子显微镜（FESEM）、透射电子显微镜（TEM）、X 射线衍射（XRD）、紫外-可见分光光度法和傅立叶变换红外光谱（FTIR）进行了广泛的表征。将粘合剂中的氧化锌纳米结构浆料涂在玻璃碳电极（GCE）上。使用线性扫描伏安法（LSV）评估了传感器对纳布啡的反应能力，通过微调 pH 值达到了最佳性能。传感器对浓度高达 150.0 nM 的纳布啡呈比例响应，具有良好的回归系数 (R2)，检测限为 6.20 nM（信噪比为 3）。对各种干扰物质的选择性进行了验证，并通过实际样品分析确认了其功效，突出表明了该传感器在纳布啡检测方面的成功应用。

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来源期刊

Analytical biochemistry 生物-分析化学

CiteScore

5.70

自引率

0.00%

发文量

283

审稿时长

44 days

期刊介绍： The journal''s title Analytical Biochemistry: Methods in the Biological Sciences declares its broad scope: methods for the basic biological sciences that include biochemistry, molecular genetics, cell biology, proteomics, immunology, bioinformatics and wherever the frontiers of research take the field. The emphasis is on methods from the strictly analytical to the more preparative that would include novel approaches to protein purification as well as improvements in cell and organ culture. The actual techniques are equally inclusive ranging from aptamers to zymology. The journal has been particularly active in: -Analytical techniques for biological molecules- Aptamer selection and utilization- Biosensors- Chromatography- Cloning, sequencing and mutagenesis- Electrochemical methods- Electrophoresis- Enzyme characterization methods- Immunological approaches- Mass spectrometry of proteins and nucleic acids- Metabolomics- Nano level techniques- Optical spectroscopy in all its forms. The journal is reluctant to include most drug and strictly clinical studies as there are more suitable publication platforms for these types of papers.