Newborn Dried Blood Spot Folate in Relation to Maternal Self-reported Folic Acid Intake, Autism Spectrum Disorder, and Developmental Delay.

IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Epidemiology Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI:10.1097/EDE.0000000000001750
Rebecca J Schmidt, Amanda J Goodrich, Lora Delwiche, Robin L Hansen, Claire L Simpson, Daniel Tancredi, Heather E Volk
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引用次数: 0

Abstract

Background: Maternal folic acid intake has been associated with decreased risk for neurodevelopmental disorders including autism spectrum disorder (ASD). Genetic differences in folate metabolism could explain some inconsistencies. To our knowledge, newborn folate concentrations remain unexamined.

Methods: We measured folate in archived newborn dried blood spots of children from the CHARGE (Childhood Autism Risks from Genetics and the Environment) case-control study who were clinically confirmed at 24-60 months to have ASD (n = 380), developmental delay (n = 128), or typical development (n = 247). We quantified monthly folic acid intake from maternally-reported supplements and cereals consumed during pregnancy and 3 months prior. We assessed associations of newborn folate with maternal folic acid intake and with ASD or developmental delay using regression. We stratified estimates across maternal and child MTHFR genotypes.

Results: Among typically developing children, maternal folic acid intake in prepregnancy and each pregnancy month and prepregnancy prenatal vitamin intake were positively associated with newborn folate. Among children with ASD, prenatal vitamin intake in pregnancy months 2-9 was positively associated with newborn folate. Among children with developmental delay, maternal folic acid and prenatal vitamins during the first pregnancy month were positively associated with neonatal folate. Associations differed by MTHFR genotype. Overall, neonatal folate was not associated with ASD or developmental delay, though we observed associations with ASD in children with the MTHFR 677 TT genotype (odds ratio: 1.76, 95% CI = 1.19, 2.62; P for interaction = 0.08).

Conclusion: Maternal prenatal folic acid intake was associated with neonatal folate at different times across neurodevelopmental groups. Neonatal folate was not associated with reduced ASD risk. MTHFR genotypes modulated these relationships.

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新生儿干血样叶酸与母亲自我报告的叶酸摄入量、自闭症谱系障碍和发育迟缓的关系。
背景:母亲叶酸摄入量与神经发育障碍(包括自闭症谱系障碍)风险的降低有关。叶酸代谢的遗传差异可以解释一些不一致之处。据我们所知,新生儿叶酸浓度仍未得到研究:我们测量了CHARGE(遗传和环境导致的儿童自闭症风险)病例对照研究中存档的新生儿干血斑中的叶酸含量,这些儿童在24-60个月时经临床证实患有ASD(380人)、发育迟缓(128人)或典型发育(247人)。我们从孕妇报告的孕期及之前 3 个月的补充剂和谷物中量化了每月的叶酸摄入量。我们使用回归法评估了新生儿叶酸与母体叶酸摄入量以及 ASD 或发育迟缓之间的关联。我们对母亲和儿童的 MTHFR 基因型进行了分层估计:结果:在发育正常的儿童中,孕前和每个妊娠月份的母体叶酸摄入量以及孕前产前维生素摄入量与新生儿叶酸呈正相关。在患有 ASD 的儿童中,怀孕 2-9 个月的产前维生素摄入量与新生儿叶酸呈正相关。在发育迟缓儿童中,母亲叶酸和怀孕第一个月的产前维生素摄入量与新生儿叶酸呈正相关。MTHFR基因型不同,相关性也不同。总体而言,新生儿叶酸与 ASD 或发育迟缓无关,但我们观察到 MTHFR 677 TT 基因型儿童的叶酸与 ASD 有关(几率比:1.76,95% CI = 1.19,2.62;交互作用 P = 0.08):母亲产前叶酸摄入量与各神经发育组新生儿不同时期的叶酸摄入量有关。新生儿叶酸与ASD风险降低无关。MTHFR基因型调节了这些关系。
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来源期刊
Epidemiology
Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.70%
发文量
177
审稿时长
6-12 weeks
期刊介绍: Epidemiology publishes original research from all fields of epidemiology. The journal also welcomes review articles and meta-analyses, novel hypotheses, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.
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