Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics.

IF 2.2 4区医学 Q3 ONCOLOGY Cancer Causes & Control Pub Date : 2024-10-01 Epub Date: 2024-06-25 DOI:10.1007/s10552-024-01894-0

Madeline M Tomlinson, Felicia Pugh, Alexandra N Nail, Johnnie D Newton, Karen Udoh, Stephie Abraham, Sandy Kavalukas, Brian Guinn, Rulla M Tamimi, Francine Laden, Hari S Iyer, J Christopher States, Matthew Ruther, C Tyler Ellis, Natalie C DuPré

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Abstract

Purpose: Cancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms affecting cancer. The role of known metal carcinogens (i.e., cadmium, arsenic, nickel, chromium(VI)) in breast and colorectal carcinogenesis is largely unknown. Historically marginalized communities are disproportionately exposed to metals, which could explain cancer disparities. We examined area-based metal exposures and odds of residing in breast and colorectal cancer hotspots utilizing state tumor registry data and described the characteristics of those living in heavy metal-associated cancer hotspots.

Methods: Breast and colorectal cancer hotspots were mapped across Kentucky, and area-based ambient metal exposure to cadmium, arsenic, nickel, and chromium(VI) were extracted from the 2014 National Air Toxics Assessment for Kentucky census tracts. Among colorectal cancer (n = 56,598) and female breast cancer (n = 77,637) diagnoses in Kentucky, we used logistic regression models to estimate Odds Ratios (ORs) and 95% Confidence Intervals to examine the association between ambient metal concentrations and odds of residing in cancer hotspots, independent of individual-level and neighborhood risk factors.

Results: Higher ambient metal exposures were associated with higher odds of residing in breast and colorectal cancer hotspots. Populations in breast and colorectal cancer hotspots were disproportionately Black and had markers of lower socioeconomic status. Furthermore, adjusting for age, race, tobacco and neighborhood factors did not significantly change cancer hotspot ORs for ambient metal exposures analyzed.

Conclusion: Ambient metal exposures contribute to higher cancer rates in certain geographic areas that are largely composed of marginalized populations. Individual-level assessments of metal exposures and cancer disparities are needed.

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与重金属有关的乳腺癌和大肠癌热点地区及其人口和社会经济特征。

目的：癌症登记为确定大量人群中的癌症集群和有效检查影响癌症的潜在环境危害提供了一个途径。已知金属致癌物（如镉、砷、镍、铬（VI））在乳腺癌和结直肠癌发生中的作用在很大程度上尚属未知。历史上被边缘化的社区接触金属的比例过高，这可能是癌症差异的原因。我们利用州肿瘤登记数据研究了基于地区的金属暴露和居住在乳腺癌和结直肠癌热点地区的几率，并描述了居住在重金属相关癌症热点地区人群的特征：绘制了肯塔基州的乳腺癌和结直肠癌热点地区图，并从 2014 年肯塔基州人口普查区国家空气有毒物质评估中提取了基于地区的环境金属镉、砷、镍和铬（VI）暴露量。在肯塔基州确诊的结直肠癌（n = 56,598）和女性乳腺癌（n = 77,637）患者中，我们使用逻辑回归模型估算了几率比（ORs）和 95% 置信区间，以研究环境金属浓度与居住在癌症热点地区几率之间的关系，而不受个人水平和邻里风险因素的影响：环境金属暴露量越高，居住在乳腺癌和结直肠癌热点地区的几率就越高。乳腺癌和结直肠癌热点地区的人口中，黑人比例过高，且社会经济地位较低。此外，对年龄、种族、烟草和邻里因素进行调整后，所分析的环境金属暴露的癌症热点OR并没有显著变化：结论：在某些主要由边缘化人群组成的地理区域，环境金属暴露会导致癌症发病率升高。需要对金属暴露和癌症差异进行个人层面的评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生

CiteScore

3.90

自引率

4.30%

发文量

130

审稿时长

6.6 months

期刊介绍： Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.