An SEIR network epidemic model with manual and digital contact tracing allowing delays

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-22 DOI:10.1016/j.mbs.2024.109231
Dongni Zhang, Tom Britton
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Abstract

We consider an SEIR epidemic model on a network also allowing random contacts, where recovered individuals could either recover naturally or be diagnosed. Upon diagnosis, manual contact tracing is triggered such that each infected network contact is reported, tested and isolated with some probability and after a random delay. Additionally, digital tracing (based on a tracing app) is triggered if the diagnosed individual is an app-user, and then all of its app-using infectees are immediately notified and isolated. The early phase of the epidemic with manual and/or digital tracing is approximated by different multi-type branching processes, and three respective reproduction numbers are derived. The effectiveness of both contact tracing mechanisms is numerically quantified through the reduction of the reproduction number. This shows that app-using fraction plays an essential role in the overall effectiveness of contact tracing. The relative effectiveness of manual tracing compared to digital tracing increases if: more of the transmission occurs on the network, when the tracing delay is shortened, and when the network degree distribution is heavy-tailed. For realistic values, the combined tracing case can reduce R0 by 20%–30%, so other preventive measures are needed to reduce the reproduction number down to 1.2–1.4 for contact tracing to make it successful in avoiding big outbreaks.

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SEIR 网络流行病模型,采用人工和数字接触追踪技术,允许延迟。
我们考虑的是网络上的 SEIR 流行病模型,该模型也允许随机接触,恢复的个体可以自然恢复,也可以被诊断出来。一旦确诊,就会触发人工接触追踪,这样每个受感染的网络接触者都会以一定的概率并经过随机延迟后被报告、检测和隔离。此外,如果确诊者是应用程序用户,则会触发数字追踪(基于追踪应用程序),然后立即通知并隔离所有使用应用程序的受感染者。采用人工和/或数字追踪的流行病早期阶段近似于不同的多类型分支过程,并分别得出三个繁殖数。两种接触追踪机制的有效性都通过减少繁殖数量进行了数值量化。这表明,应用程序使用率对联系人追踪的整体效果起着至关重要的作用。在以下情况下,人工追踪相对于数字追踪的效果会提高:更多的传输发生在网络上;追踪延迟缩短;网络度分布呈重尾状。就实际值而言,联合追踪可将 R0 降低 20%-30%,因此需要采取其他预防措施,将接触追踪的繁殖数降至 1.2-1.4,才能成功避免大爆发。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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