A Pt nanoenzyme- and BODIPY-loaded nanoscale covalent organic framework for relieving intratumoural hypoxia to enhance photodynamic therapy†

IF 3.5 3区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Dalton Transactions Pub Date : 2024-06-25 DOI:10.1039/D4DT00999A
Kai-Xuan Zhang, Bo Wang, Wen-Yan Li, Yang Song, Tian Song, Yan-An Li and Yu-Bin Dong
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Abstract

Herein, we report a composite COF material loaded with a Pt nanoenzyme and an organic photosensitizer BODIPY, synthesized via a stepwise post-synthetic modification. The obtained Pt@COF-BDP nanoparticles can efficiently and continuously convert H2O2 to O2, thereby increasing the efficiency of single-linear oxygen production and achieving efficient tumor inhibition.

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一种铂纳米酶和 BODIPY 负载纳米级共价有机框架,用于缓解瘤内缺氧以增强光动力疗法
在此,我们报告了一种负载有铂纳米酶和有机光敏剂 BODIPY 的复合 COF 材料,该材料是通过分步后合成修饰合成的。所获得的 Pt@COF-BDP 纳米颗粒能高效、持续地将 H2O2 转化为 O2,从而提高单线制氧效率,达到高效抑制肿瘤的目的。
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来源期刊
Dalton Transactions
Dalton Transactions 化学-无机化学与核化学
CiteScore
6.60
自引率
7.50%
发文量
1832
审稿时长
1.5 months
期刊介绍: Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.
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