Dalton Transactions最新文献

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CO2 uptake potential of cerium(III) triazolates and tetrazolates 三唑酸铈和四唑酸铈的CO2吸收势

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-27 DOI: 10.1039/d6dt00453a

Jonas Riedmaier, Caecilia Maichle-Moessmer, Reiner Anwander

Cerous triazolates and tetrazolates were synthesised utilising Ce[N(SiMe3)2]3 as precursor. The transaminiation with HtzMe,Me (tzMe,Me = 3,5-dimethyl-1,2,4-triazolyl), HtrzBz (trzBz = 1,2,3-benzotriazolyl) and HtetPh (tetPh = 5-phenyltetrazolyl) gave insoluble, white solids while HtzPh,Ph (tzPh,Ph = 3,5-diphenyl-1,2,4-triazolyl) led to the isolation of the monomeric complex Ce(tzPh,Ph)3(thf)3. Triazolate [Ce(tzMe,Me)3]n favoured exhaustive CO2 insertion, while less basic triazolate [Ce(trzBz)3]n and tetrazolate [Ce(tetPh)3]n displayed only partial and no insertion, respectively. Ce(tzPh,Ph)3(thf)3 reacts with CO2 in aromatic solvents but the product could not be identified. Addition of the azoles to Ce[N(SiMe3)2]3/Me3TACN mixtures afforded discrete complexes (Me3TACN)Ce(az)3(thf) (az = tzMe,Me, trzBz, tetPh), which however do no insert CO2 at ambient temperature. Treatment of (Me3TACN)Ce(trzBz)3(thf) with CO2 resulted in the separation of Me3TACN and precipitation of a white powder. The respective pyrazolate (Me3TACN)Ce(pzMe,Me)3 (pzMe,Me = 3,5-dimethylpyrazolyl) featuring more basic azolato ligands engaged in CO2 insertion forming the previously reported complex [Ce4(pzMe,Me∙CO2)12]

以Ce[N(SiMe3)2]3为前驱体合成了铈三唑酸盐和四唑酸盐。HtzMe、Me （tzMe,Me = 3,5-二甲基-1,2,4-三唑基）、htzbz （trzBz = 1,2,3-苯并三唑基）和HtetPh （tetPh = 5-苯基四唑基）经转氨化反应得到不溶性白色固体，HtzPh、Ph （tzPh,Ph = 3,5-二苯基-1,2,4-三唑基）分离得到单体配合物Ce(tzPh,Ph)3(thf)3。三唑酸盐[Ce(tzMe,Me)3]n有利于彻底插入CO2，而碱性较弱的三唑酸盐[Ce(trzBz)3]n和四唑酸盐[Ce(tetPh)3]n分别仅部分插入CO2和不插入CO2。Ce(tzPh,Ph)3(thf)3在芳香族溶剂中与CO2反应，产物无法鉴定。在Ce[N(SiMe3)2]3/Me3TACN混合物中加入偶氮，得到离散配合物（Me3TACN）Ce(az)3(thf) (az = tzMe,Me, trzBz, tetPh)，但在室温下不插入CO2。用CO2处理（Me3TACN）Ce(trzBz)3(thf)，使Me3TACN分离，沉淀出白色粉末。相应的吡唑酸酯（Me3TACN）Ce(pzMe,Me)3 （pzMe,Me = 3,5-二甲基吡唑基）具有更多的碱性偶氮配体参与CO2插入，形成先前报道的复合物[Ce4(pzMe,Me∙CO2)12]

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引用次数: 0

A metal–organic framework Ce-BDA for triple-modal cancer therapy: chemodynamic therapy, chemotherapy and immunotherapy 金属-有机框架Ce-BDA用于三模式癌症治疗：化学动力治疗，化疗和免疫治疗

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-27 DOI: 10.1039/d6dt00195e

Liyuan Sang, Qianru Ye, Yu Shi, Heng Liu, Bing Wang, Wenxin Lin, Quan Hu

A cerium-based metal–organic framework, Ce-BDA, was selected and further loaded with manganese ions (Mn²⁺) and chemotherapeutic drug doxorubicin (DOX) to construct a multifunctional system, denoted as Mn&DOX@Ce-BDA. Taking advantage of the valence-switching capability of Ce³⁺/Ce⁴⁺, Mn&DOX@Ce-BDA can efficiently trigger reactive oxygen species (ROS) production via a Fenton-like reaction in weakly acidic tumor microenvironment. Notably, the released Mn²⁺ serves a dual function as it acts as a co-catalyst to amplify ROS generation for enhanced chemodynamic therapy (CDT) while also activating dendritic cells to secrete pro-inflammatory cytokines and interferons, thereby exerting potent immunotherapeutic effects. Furthermore, this nanoplatform enables the tumor-specific controlled release of DOX, facilitating the synergy of chemotherapy. By integrating chemodynamic therapy, chemotherapy, and immunotherapy into a single nanosystem, Mn&DOX@Ce-BDA achieves highly efficient and selective tumor cell killing, providing a promising triple-combination therapeutic strategy to overcome the limitations of conventional cancer treatments.

选择铈基金属有机骨架Ce-BDA，并进一步负载锰离子（Mn2+）和化疗药物阿霉素（DOX），构建多功能体系，表示为Mn&；DOX@Ce-BDA。Mn&；DOX@Ce-BDA利用Ce3+/Ce4+的价转换能力，可以在弱酸性肿瘤微环境中通过芬顿样反应高效触发活性氧（ROS）的产生。值得注意的是，释放的Mn2+具有双重功能，它可以作为一种辅助催化剂，放大ROS的产生，以增强化学动力学治疗（CDT），同时还可以激活树突状细胞分泌促炎细胞因子和干扰素，从而发挥强大的免疫治疗作用。此外，该纳米平台能够实现肿瘤特异性DOX的控制释放，促进化疗的协同作用。通过将化学动力学治疗、化疗和免疫治疗整合到一个纳米系统中，Mn&；DOX@Ce-BDA实现了高效和选择性的肿瘤细胞杀伤，提供了一种有前途的三联治疗策略，以克服传统癌症治疗的局限性。

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引用次数: 0

Refining hydrogen positions in α-FeOOH through combined neutron diffraction and computational techniques. 用中子衍射和计算相结合的方法精炼α-FeOOH中氢的位置。

IF 3.3 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-26 DOI: 10.1039/d5dt00217f

Yusuke Nambu, Akihide Kuwabara, Masahiro Kawamata, Seira Mori, Megumi Okazaki, Kazuhiko Maeda

The hydrogen positions and magnetic structure of goethite α-FeOOH, a key component of iron rust, were examined through neutron diffraction. All symmetry-allowed magnetic structures under the space group Pnma with the magnetic wavevector q_m = (0, 0, 0) r.l.u. were analysed using irreducible representation and magnetic space group approaches. The magnetic moments aligned along the b-axis form antiferromagnetic spin arrangements, as reproduced by first-principles calculations. Accurately determining the hydrogen positions is crucial for understanding the mechanism of catalytic reduction of CO₂ in α-FeOOH. These positions were precisely identified through diffraction and calculations, highlighting the effectiveness of using both methods for undeuterated compounds.

采用中子衍射法对铁锈关键成分针铁矿α-FeOOH的氢位和磁性结构进行了研究。利用不可约表示和磁空间群方法，对磁波qm = (0,0,0) r.l.u的空间群Pnma下所有允许对称的磁结构进行了分析。沿着b轴排列的磁矩形成反铁磁自旋排列，由第一性原理计算再现。准确确定氢的位置对于理解α-FeOOH催化还原CO2的机理至关重要。通过衍射和计算精确地确定了这些位置，突出了使用这两种方法对未氘化化合物的有效性。

引用次数: 0

Solid-state Molecular OrganoMetallic Chemistry (SMOM): A Users’ Guide to In Crystallo Single-Crystal to Single-Crystal Transformations using Solid/Gas Methods 固态分子有机金属化学（SMOM）：使用固体/气体方法从单晶到单晶转化的用户指南

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-26 DOI: 10.1039/d6dt00444j

Kris Mark Altus, Samantha Kathleen Furfari, Joe Goodall, Matthew Robert Gyton, Jack Heaton, Chloe Johnson, Alasdair I. McKay, Mads Sondrup Møller, Sebastian D Pike, Andrew S Weller

In crystallo solid/gas solid-state molecular organometallic (SMOM) chemistry offers unique opportunities in organometallic synthesis and catalysis. The methodology provides routes to synthesise complexes that are challenging to isolate and characterise in solution, with the confined lattice environment providing additional opportunities to control reaction pathways and selectivities in both synthesis and catalysis. The power of the method comes in its simplicity, combined with the orthogonal analytical techniques that can be used characterise the products. This tutorial review is a user guide to SMOM, stepping though each aspect that needs to be considered for such solid/gas in crystallo reactivity, and encourages others to use the method in their own research.

固体/气体固态分子有机金属（SMOM）化学为有机金属合成和催化提供了独特的机会。该方法为在溶液中分离和表征具有挑战性的配合物的合成提供了途径，有限的晶格环境为控制合成和催化中的反应途径和选择性提供了额外的机会。该方法的强大之处在于其简单性，并结合了可用于表征产品特征的正交分析技术。本教程回顾是SMOM的用户指南，逐步介绍了需要考虑这种固体/气体结晶反应性的每个方面，并鼓励其他人在自己的研究中使用该方法。

引用次数: 0

Synergistic properties of biological interest of a ruthenium (II) compound 钌（II）化合物的生物增效性研究

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-26 DOI: 10.1039/d5dt02842f

Renan Ribeiro Bertoloni, Hugo Elias Barbosa, Alexia Marques Silva, Amanda Becceneri, Roberto Santana da Silva, Bernardo Almeida Iglesias, Claudia Turro, Sofia Nikolaou

This work reports the synthesis, characterization and verification of synergistic properties of a nitrite ruthenium(II) compound [Ru(tpy)(dppz)(NO2)](PF6) (tpy = 2,2′:6′,2″-terpyridine; dppz = dipyrido[3,2-a:2’,3’-c]phenazine), which is compared to its chlorine precursor [Ru(tpy)(dppz)(Cl)](PF6). 1H-NMR and IR analysis shows the absence of any isomers other than the N-bonded nitrite species. Electronic spectroscopy analysis reveals the influence of the π-acceptor NO2- ligand on the structure of the complex, shifting the MLCT bands to higher energies and increasing the lifetime of its excited state, measured by fs-TA and TCSPC spectroscopies. The nitrosyl species [Ru(tpy)(dppz)(NO)]3+ is highly unstable due to the low electronic density on Ru center, as shown by pKa measurements and DFT calculations. The nitrite compound proved to be able to interact strongly with DNA, generate 1O2 and release NO by light stimulation, making it an interesting example of a synergetic compound possessing these properties simultaneously. Improving these results by adjusting the tridentate ligand provides a strategy to develop new Ru candidates for metallofarmaceuticals as anticancer drugs

本文报道了一种亚硝酸盐钌（II）化合物[Ru(tpy)(dppz)(NO2)](PF6) （tpy = 2,2 ':6 ‘，2″-三吡啶；dppz =二吡啶[3,2-a:2 ’，3 ' -c]吩那嗪）的合成、表征和增效性能的验证，并与它的氯前体[Ru(tpy)(dppz)(Cl)]（PF6）进行了比较。1H-NMR和IR分析表明，除了n键亚硝酸盐外，不存在任何异构体。电子能谱分析揭示了π受体NO2-配体对配合物结构的影响，通过fs-TA和TCSPC光谱测量，使MLCT带向更高的能量移动，增加了其激发态的寿命。pKa测量和DFT计算表明，亚硝基物质[Ru(tpy)(dppz)(NO)]3+由于Ru中心的低电子密度而高度不稳定。亚硝酸盐化合物被证明能够与DNA强相互作用，在光刺激下产生1O2并释放NO，使其成为同时具有这些特性的协同化合物的有趣例子。通过调整三齿配体来改善这些结果，为开发新的金属药物候选物作为抗癌药物提供了策略

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引用次数: 0

Doping-engineered PdRu bimetallic nanoalloys with nitric oxide delivery for synergetic photodynamic therapy. 掺杂工程PdRu双金属纳米合金与一氧化氮递送用于协同光动力治疗。

IF 3.3 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-25 DOI: 10.1039/d5dt02852c

Chengchen Jia, Shiyu Zhang, Wubin Lv, Siyi Li, Yuxuan Zhao, Shuming Dong, He Ding, Ziaur Rehman, Piaoping Yang

Photodynamic therapy (PDT) is often constrained by the insufficient therapeutic effect of reactive oxygen species (ROS) and poor stability of photosensitizers. To address these challenges, PdRu bimetallic nanoalloys (PdRu@PL) loaded with L-arginine (L-arg) as a nitric oxide (NO) donor were developed for synergistic PDT. A series of distinct morphologies-nanospheres, nanoflowers, and nanosheets-were synthesized, with the highly stable and uniformly alloyed PdRu NPs selected for further functionalization via PEGylation and L-arg loading. Under 808 nm laser irradiation, the PdRu nanoalloys exhibit excellent photothermal properties and generate ROS, including singlet oxygen and superoxide anions (˙O₂^-). The produced ˙O₂^- reacts with NO released from L-arg, forming highly cytotoxic peroxynitrite, a reactive nitrogen species. This cascade is further enhanced by catalase-like activities of the nanoalloys, which modulate the tumor microenvironment by decomposing hydrogen peroxide and alleviating hypoxia. In vitro experiments demonstrated efficient cellular uptake, concentration-dependent cytotoxicity against 4T1 cancer cells, and significant induction of apoptosis under laser exposure. In vivo studies in 4T1 tumor-bearing mice confirmed effective tumor accumulation of PdRu@PL, leading to nearly complete tumor ablation following treatment, without evident systemic toxicity. This work highlights PdRu bimetallic nanoalloys as a promising multifunctional platform for synergistic photodynamic and NO-based gas therapy, offering a strategy for enhanced anticancer efficacy.

光动力疗法（PDT）经常受到活性氧（ROS）治疗效果不足和光敏剂稳定性差的限制。为了解决这些挑战，以l -精氨酸（L-arg）作为一氧化氮（NO）供体的PdRu双金属纳米合金（PdRu@PL）被开发用于协同PDT。合成了一系列不同的形态——纳米球、纳米花和纳米片，并选择了高度稳定和均匀的PdRu NPs，通过聚乙二醇化和L-arg负载进行进一步的功能化。在808 nm激光照射下，PdRu纳米合金表现出优异的光热性能，并产生ROS，包括单线态氧和超氧阴离子（˙O2-）。产生的˙O2-与L-arg释放的NO反应，形成高细胞毒性的过氧亚硝酸盐，一种活性氮物质。纳米合金的过氧化氢酶样活性进一步增强了这种级联反应，纳米合金通过分解过氧化氢和缓解缺氧来调节肿瘤微环境。体外实验证明了激光照射下有效的细胞摄取，对4T1癌细胞的浓度依赖性细胞毒性，以及显著的细胞凋亡诱导。在4T1荷瘤小鼠体内的研究证实了PdRu@PL有效的肿瘤积累，导致治疗后肿瘤几乎完全消融，无明显的全身毒性。本研究强调PdRu双金属纳米合金作为一种有前途的多功能平台，用于协同光动力和no基气体治疗，为增强抗癌功效提供了一种策略。

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引用次数: 0

Insertion of SnCl₂ into the Pd–Cl Bond: Mechanistic Elucidation and Antitumor Evaluation of Trichlorostannyl Palladium-NHC Allyl Complexes in Ovarian Cancer Models SnCl 2插入Pd-Cl键：卵巢癌模型中三氯斯坦基钯- nhc烯丙基配合物的机制阐明和抗肿瘤评价

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-25 DOI: 10.1039/d6dt00680a

Eleonora Botter, Valentina Lauteri, Alessandro Rubbi, Laura Orian, Matteo Forner, Valentina Gandin, Nicola Demitri, Vincenzo Canzonieri, Flavio Rizzolio, Enrico Cavarzerani, Fabiano Visentin, Thomas Scattolin

The development of effective and selective metal-based chemotherapeutics remains a central challenge in ovarian cancer treatment, particularly in addressing resistance to platinum agents. Herein, we report the design, synthesis, and biological evaluation of a novel series of heterobimetallic Pd(II)/Sn(II) η³-allyl complexes bearing N-heterocyclic carbene (NHC) ligands. Thirteen complexes were efficiently prepared via SnCl₂ insertion into the Pd–Cl bond of allyl–palladium precursors, and fully characterized by NMR, IR, and X-ray diffraction. DFT calculations revealed a stepwise reaction mechanism initiated by a favourable Sn···Cl interaction, followed by insertion into the Pd–Cl bond. All compounds exhibited pronounced cytotoxicity across cisplatin-sensitive, cisplatin-resistant, and high-grade serous ovarian cancer (HGSOC) cell lines, with selected derivatives, particularly 2i and 2k, showing remarkable tumour selectivity. Lead compound 2i retained potent activity in patient-derived tumour organoids (PDTOs), including a platinum-resistant model, while remaining inactive in a non-malignant fallopian tube epithelium organoid, highlighting its favourable therapeutic window. Mechanistic studies indicate that 2i primarily targets Thioredoxin Reductase (TrxR) and mitochondria, as evidenced by early cytochrome c release and loss of mitochondrial membrane potential, with subsequent DNA damage occurring downstream, consistent with a mitochondria-driven apoptotic pathway distinct from classical platinum drugs. These findings position Pd(II)/Sn(II) η³-allyl complexes, and 2i in particular, as promising candidates for metal-based anticancer therapy.

开发有效和选择性的金属基化疗药物仍然是卵巢癌治疗的核心挑战，特别是在解决铂类药物的耐药性方面。在此，我们报道了一系列新的含n杂环碳（NHC）配体的杂双金属Pd(II)/Sn(II) η³-烯丙基配合物的设计、合成和生物学评价。通过在烯丙基钯前驱体的Pd-Cl键上插入SnCl 2，制备了13个配合物，并通过NMR、IR和x射线衍射对其进行了表征。DFT计算揭示了一个循序渐进的反应机制，由有利的Sn···Cl相互作用引发，然后插入Pd-Cl键。所有化合物在顺铂敏感、顺铂耐药和高级别浆液性卵巢癌（HGSOC）细胞系中均表现出明显的细胞毒性，其中选定的衍生物，特别是2i和2k，显示出显著的肿瘤选择性。先导化合物2i在患者源性肿瘤类器官（PDTOs）（包括铂耐药模型）中保持有效活性，而在非恶性输卵管上皮类器官中保持无活性，突出其有利的治疗窗口。机制研究表明，2i主要靶向硫氧还蛋白还原酶（TrxR）和线粒体，细胞色素c的早期释放和线粒体膜电位的丧失证明了这一点，随后的DNA损伤发生在下游，与线粒体驱动的凋亡途径相一致，不同于经典铂类药物。这些发现表明Pd(II)/Sn(II) η³-烯丙基配合物，特别是2i，是金属基抗癌治疗的有希望的候选者。

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引用次数: 0

The Role of Exciplex Charge-Transfer Character and Reorganization Energy in Steering Oxygen Quenching Pathways of Chromium(III) Excited States 杂络合物电荷转移特性和重组能在铬（III）激发态氧猝灭过程中的作用

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-25 DOI: 10.1039/d6dt00398b

Aya S Amer, Ayman Abdel-Shafi, Ahmed M. M. Alazaly, Mahmoud A. El-Jemni, Hamdy Hassanien Hassan, Hesham Samir Abdel-Samad

In this study we report the synthesis, characterization and photophysical properties of some [Cr(bpy)2L](OTf)3 complexes. The steady-state absorption and luminescence emission of these complexes were measured in 1 M HCl. The obtained luminescence quantum yields were found to be in the range 3.4 -12.17 × 10-3, being the lowest for [Cr(55DMB)2(bpy)]3+ and highest for [Cr(55DMB)2(44DMB)]3+. Measurements of the transient absorption spectra in 1 M HCl under degassed and oxygen-saturated conditions revealed no significant differences at any observed time delay. This consistency demonstrates the absence of any ion-separated species in the excited state. The excited state lifetime was in the range of 79 to 136 μs. Oxygen quenching of the excited states of the studied complexes shows a quenching rate constant in the range of 2.75 – 3.73 × 107 M-1 s-1 in 1M HCL aqueous solution and singlet oxygen quantum yield in the range 0.16 to 0.25 in D2O. The calculated efficiency of singlet oxygen production was found to be in the range 0.32 to 0.58. Determination of the oxidation potential Cr(+3/+4) for the studied complexes were found to be in the range 0.31 to 0.60 V vs SCE in acetonitrile and accordingly the free energy change for complete electron transfer ΔGCET, were found to be in the range -68.87 to -40.69 kJ mol-1. The mechanism of quenching is discussed based on a spin statistical model, which quantifies the balance between charge transfer and other deactivation pathways with a parameter pCT, which was evaluated for the current series of complexes to be in the range 0.57 to 0.72. The activation energy for the charge transfer exciplexes were calculated and found to be in the range 25.67 to 27.35 kJ mol-1 using a reorganization energy, λ, for the studied series of chromium complexes of 128 kJmol-1 and charge transfer character of the exciplexes, ẟ, were found to be 47.9. Based on this charge transfer character, individual reorganization energy, λ, for each complex was evaluated and correlated to the charge transfer quenching rate constant.

本文报道了一些[Cr(bpy)2L](OTf)3配合物的合成、表征及其光物理性质。在1 M HCl溶液中测定了这些配合物的稳态吸收和发光。所得发光量子产率在3.4 ~ 12.17 × 10-3之间，其中[Cr(55DMB)2(bpy)]3+的发光量子产率最低，[Cr(55DMB)2(44DMB)]3+的发光量子产率最高。在脱气和氧饱和条件下，在1 M HCl中的瞬态吸收光谱测量显示，在任何观察到的时间延迟上都没有显着差异。这种一致性表明激发态中不存在任何离子分离的物质。激发态寿命在79 ~ 136 μs之间。所研究的配合物激发态的氧猝灭表明，在1M HCL水溶液中的猝灭速率常数为2.75 ~ 3.73 × 107 M-1 s-1，在D2O中的单线态氧量子产率为0.16 ~ 0.25。计算得到的单线态产氧效率在0.32 ~ 0.58之间。所研究的配合物在乙腈中氧化电位Cr（+3/+4）的测定范围在0.31 ~ 0.60 V vs SCE之间，相应的电子完全转移的自由能变化ΔGCET在-68.87 ~ -40.69 kJ mol-1之间。基于自旋统计模型讨论了猝灭机理，该模型用参数pCT量化了电荷转移和其他失活途径之间的平衡，对当前系列配合物的评估范围为0.57 ~ 0.72。用重组能λ计算了128 kJmol-1的铬配合物的电荷转移复合物的活化能在25.67 ~ 27.35 kJmol-1之间，复合物的电荷转移特性ẟ为47.9。基于这种电荷转移特性，计算了每个配合物的单个重组能λ，并将其与电荷转移猝灭速率常数进行了关联。

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引用次数: 0

Design and Development of a Novel Humidity-Tolerant Gas Sensing Material for Reliable and High-Performance Ethanol Detection 一种新型耐湿气敏材料的设计与开发，用于可靠和高性能的乙醇检测

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-25 DOI: 10.1039/d6dt00129g

Dongting Wang, Shan Ding, Su'e Chen, Dongyu Shan, Chunjie Jiang, Xinning Zhang

Ethanol sensing with enhanced humidity tolerance was achieved using octahedral nanostructures of pure SnO 2 , Sb-doped SnO 2 , and Pt-loaded Sb-SnO 2 synthesized via a solvothermal method. All samples exhibited uniform octahedral morphologies (~100 nm). The 6 wt% Pt/6% Sb-SnO 2 sensor, operating at 100 °C, demonstrated a high response (~43) to 100 ppm ethanol, fast response and recovery, a low detection limit (~7.57 ppm), and excellent stability over 20 days (<10% variation) under fluctuating humidity. These superior performances are attributed to the synergistic effects of Sb doping and Pt loading, which improve ethanol sensitivity and suppress humidity interference. Owing to its low working temperature, fine particle size, high sensitivity, and robust durability, the sensor offers a promising platform for real-time ethanol monitoring in humid environments.

采用溶剂热法合成了纯sno2、sb掺杂sno2和pt负载sb - sno2的八面体纳米结构，实现了具有增强耐湿性的乙醇传感。所有样品均呈现均匀的八面体形貌（~100 nm）。6 wt% Pt/6% sb - sno2传感器在100°C下工作，对100 ppm乙醇具有高响应（~43），快速响应和恢复，低检测限（~7.57 ppm），以及在波动湿度下超过20天（<；10%变化）的出色稳定性。这些优异的性能是由于Sb掺杂和Pt负载的协同作用，提高了乙醇敏感性，抑制了湿度干扰。由于其工作温度低，粒度细，灵敏度高，耐用性强，该传感器为潮湿环境中的实时乙醇监测提供了一个很有前途的平台。

引用次数: 0

Gold(I)–indomethacin anticancer candidates with anti-breast cancer stem cell properties 金(I) -吲哚美辛抗癌候选物具有抗乳腺癌干细胞特性

IF 4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions

Pub Date : 2026-03-25 DOI: 10.1039/d6dt00194g

Nestor Bracho Pozsoni, Chiara Donati, Laura Rigon, Fatima Ali Bouye, Tom Planckaert, Nikolaos V. Tzouras, Kristof Van Hecke, Valentina Gandin, Thomas Scattolin, Steven P. Nolan

The rational design, sustainable synthesis, and comprehensive biological evaluation of a new family of gold(I)–indomethacin complexes bearing N-heterocyclic carbene (NHC) ligands are reported. The mild, scalable synthetic protocol affords the first reported examples of well-defined [Au(NHC)(indomethacin)] complexes that display robust chemical and thermal stability and exhibit potent antiproliferative activity across a panel of human cancer cell lines, frequently outperforming cisplatin, including in cisplatin-resistant models. Notably, these gold(I)–indomethacin derivatives retain strong cytotoxicity against breast cancer stem cells (CSCs)-like populations and demonstrate superior efficacy in physiologically relevant 3D spheroid models. Mechanistic investigations reveal that their anticancer activity correlates with efficient inhibition of thioredoxin reductase, disruption of intracellular thiol homeostasis, and induction of oxidative stress through reactive oxygen species generation.

报道了一类含n -杂环卡宾（NHC）的金(I) -吲哚美辛配合物的合理设计、可持续合成和综合生物学评价。温和的、可扩展的合成方案提供了首次报道的明确定义的[Au(NHC)（吲哚美辛）]复合物的例子，这些复合物显示出强大的化学和热稳定性，并在一组人类癌细胞系中表现出强大的抗增殖活性，经常优于顺铂，包括在顺铂耐药模型中。值得注意的是，这些金(I) -吲哚美辛衍生物对乳腺癌干细胞（CSCs）样群体具有很强的细胞毒性，并在生理学相关的3D球体模型中显示出卓越的功效。机制研究表明，它们的抗癌活性与有效抑制硫氧还蛋白还原酶、破坏细胞内硫醇稳态和通过活性氧生成诱导氧化应激有关。

引用次数: 0

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