Real-world evaluation of a QCM-based biosensor for exhaled air.

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS Analytical and Bioanalytical Chemistry Pub Date : 2024-12-01 Epub Date: 2024-06-26 DOI:10.1007/s00216-024-05407-5

Augusto Juste-Dolz, William Teixeira, Yeray Pallás-Tamarit, Mario Carballido-Fernández, Javier Carrascosa, Ángela Morán-Porcar, María Ángeles Redón-Badenas, María Gracia Pla-Roses, María Dolores Tirado-Balaguer, María José Remolar-Quintana, Jon Ortiz-Carrera, Ethel Ibañez-Echevarría, Angel Maquieira, David Giménez-Romero

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Abstract

The biosensor, named "virusmeter" in this study, integrates quartz crystal microbalance technology with an immune-functionalized chip to distinguish between symptomatic patients with respiratory diseases and healthy individuals by analyzing exhaled air samples. Renowned for its compact design, rapidity, and noninvasive nature, this device yields results within a 5-min timeframe. Evaluated under controlled conditions with 54 hospitalized symptomatic COVID-19 patients and 128 control subjects, the biosensor demonstrated good overall sensitivity (98.15%, 95% CI 90.1-100.0) and specificity (96.87%, 95% CI 92.2-99.1). This proof-of-concept presents an innovative approach with significant potential for leveraging piezoelectric sensors to diagnose respiratory diseases.

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对基于 QCM 的呼出空气生物传感器进行实际评估。

该生物传感器在这项研究中被命名为 "病毒仪"，它将石英晶体微天平技术与免疫功能化芯片相结合，通过分析呼出的空气样本来区分有症状的呼吸道疾病患者和健康人。该设备以设计紧凑、快速和无创而闻名，可在 5 分钟内得出结果。在受控条件下，对 54 名有症状的 COVID-19 住院患者和 128 名对照受试者进行了评估，结果表明该生物传感器具有良好的总体灵敏度（98.15%，95% CI 90.1-100.0）和特异性（96.87%，95% CI 92.2-99.1）。这一概念验证提出了一种创新方法，具有利用压电传感器诊断呼吸系统疾病的巨大潜力。

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来源期刊

Analytical and Bioanalytical Chemistry 化学-分析化学

CiteScore

8.00

自引率

4.70%

发文量

638

审稿时长

2.1 months

期刊介绍： Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.