Nanoplasmonic sensors for extracellular vesicles and bacterial membrane vesicles

IF 13.4 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Nano Convergence Pub Date : 2024-06-25 DOI:10.1186/s40580-024-00431-8

Aparna Neettiyath, Kyungwha Chung, Wenpeng Liu, Luke P. Lee

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Abstract

Extracellular vesicles (EVs) are promising tools for the early diagnosis of diseases, and bacterial membrane vesicles (MVs) are especially important in health and environment monitoring. However, detecting EVs or bacterial MVs presents significant challenges for the clinical translation of EV-based diagnostics. In this Review, we provide a comprehensive discussion on the basics of nanoplasmonic sensing and emphasize recent developments in nanoplasmonics-based optical sensors to effectively identify EVs or bacterial MVs. We explore various nanoplasmonic sensors tailored for EV or bacterial MV detection, emphasizing the application of localized surface plasmon resonance through gold nanoparticles and their multimers. Additionally, we highlight advanced EV detection techniques based on surface plasmon polaritons using plasmonic thin film and nanopatterned structures. Furthermore, we evaluate the improved detection capability of surface-enhanced Raman spectroscopy in identifying and classifying these vesicles, aided by plasmonic nanostructures. Nanoplasmonic sensing techniques have remarkable precision and sensitivity, making them a potential tool for accurate EV detection in clinical applications, facilitating point-of-care molecular diagnostics. Finally, we summarize the challenges associated with nanoplasmonic EV or bacterial MV sensors and offer insights into potential future directions for this evolving field.

Graphical Abstract

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用于细胞外囊泡和细菌膜泡的纳米质子传感器。

细胞外囊泡（EVs）是一种很有前途的疾病早期诊断工具，而细菌膜囊泡（MVs）在健康和环境监测中尤为重要。然而，EV 或细菌膜泡的检测对基于 EV 的诊断方法的临床转化提出了巨大挑战。在本综述中，我们将全面讨论纳米光子传感的基本原理，并重点介绍基于纳米光子学的光学传感器在有效识别 EV 或细菌 MV 方面的最新进展。我们探讨了为检测 EV 或细菌 MV 量身定制的各种纳米质子传感器，强调了通过金纳米粒子及其多聚体实现局部表面质子共振的应用。此外，我们还重点介绍了基于表面等离子体极化子的先进 EV 检测技术，该技术使用了等离子体薄膜和纳米图案结构。此外，我们还评估了在质子纳米结构的帮助下，表面增强拉曼光谱在识别和分类这些囊泡方面所提高的检测能力。纳米质子传感技术具有卓越的精确度和灵敏度，使其成为临床应用中准确检测 EV 的潜在工具，从而促进了床旁分子诊断。最后，我们总结了与纳米质谱 EV 或细菌 MV 传感器相关的挑战，并对这一不断发展的领域未来的潜在方向提出了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Convergence Engineering-General Engineering

CiteScore

15.90

自引率

2.60%

发文量

审稿时长

13 weeks

期刊介绍： Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects. Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.