Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode.

IF 2.6 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Beilstein Journal of Nanotechnology Pub Date : 2024-06-20 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.60

Vu Ngoc Hoang, Dang Thi Ngoc Hoa, Nguyen Quang Man, Le Vu Truong Son, Le Van Thanh Son, Vo Thang Nguyen, Le Thi Hong Phong, Ly Hoang Diem, Kieu Chan Ly, Ho Sy Thang, Dinh Quang Khieu

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Abstract

A TiO₂/graphene quantum dots composite (TiO₂/GQDs) obtained by in situ synthesis of GQDs, derived from coffee grounds, and peroxo titanium complexes was used as electrode modifier in the simultaneous electrochemical determination of uric acid and hypoxanthine. The TiO₂/GQDs material was characterized by photoluminescence, X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, and energy-dispersive X-ray mapping. The TiO₂/GQDs-GCE exhibits better electrochemical activity for uric acid and hypoxanthine than GQDs/GCE or TiO₂/GCE in differential pulse voltammetry (DPV) measurements. Under optimized conditions, the calibration plots were linear in the range from 1.00 to 15.26 μM for both uric acid and hypoxanthine. The limits of detection of this method were 0.58 and 0.68 μM for uric acid and hypoxanthine, respectively. The proposed DPV method was employed to determine uric acid and hypoxanthine in urine samples with acceptable recovery rates.

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在二氧化钛/石墨烯量子点修饰电极上同时电化学测定尿酸和次黄嘌呤。

通过原位合成从咖啡渣中提取的石墨烯量子点（GQDs）和过氧钛络合物得到的 TiO2/GQDs 复合材料（TiO2/GQDs）被用作同时电化学测定尿酸和次黄嘌呤的电极改性剂。研究人员通过光致发光、X 射线衍射、拉曼光谱、高分辨率透射电子显微镜和能量色散 X 射线绘图对 TiO2/GQDs 材料进行了表征。在差分脉冲伏安法（DPV）测量中，TiO2/GQDs-GCE 对尿酸和次黄嘌呤的电化学活性优于 GQDs/GCE 或 TiO2/GCE。在优化条件下，尿酸和次黄嘌呤的校准图在 1.00 至 15.26 μM 范围内呈线性关系。尿酸和次黄嘌呤的检出限分别为 0.58 和 0.68 μM。采用DPV法测定尿样中的尿酸和次黄嘌呤，回收率良好。

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来源期刊

Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.70

自引率

3.20%

发文量

109

审稿时长

2 months

期刊介绍： The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.