Lipids and proteins: Insights into the dynamics of assembly, recognition, condensate formation. What is still missing?

IF 1.6 4区 医学 Q4 BIOPHYSICS Biointerphases Pub Date : 2024-05-01 DOI:10.1116/6.0003662
Pablo G Argudo
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Abstract

Lipid membranes and proteins, which are part of us throughout our lives, have been studied for decades. However, every year, new discoveries show how little we know about them. In a reader-friendly manner for people not involved in the field, this paper tries to serve as a bridge between physicists and biologists and new young researchers diving into the field to show its relevance, pointing out just some of the plethora of lines of research yet to be unraveled. It illustrates how new ways, from experimental to theoretical approaches, are needed in order to understand the structures and interactions that take place in a single lipid, protein, or multicomponent system, as we are still only scratching the surface.

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脂质和蛋白质:对组装、识别和凝结物形成动力学的见解。还缺少什么?
脂质膜和蛋白质与我们的生活息息相关,对它们的研究已有几十年的历史。然而,每年都有新的发现表明,我们对它们的了解是多么的少。本文试图以一种读者易于理解的方式,在物理学家、生物学家和涉足该领域的年轻新研究人员之间架起一座桥梁,展示该领域的相关性,指出大量研究领域中尚待解开的一些谜团。这篇文章说明,要了解单个脂质、蛋白质或多组分系统中的结构和相互作用,从实验到理论方法都需要新的途径,因为我们仍然只是在浅尝辄止。
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来源期刊
Biointerphases
Biointerphases 生物-材料科学:生物材料
自引率
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发文量
35
期刊介绍: Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.
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