An Updated Review on Diabetic Nephropathy: Potential Mechanisms, Biomarkers, Therapeutic Targets and Interventional Therapies.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-06-24 DOI:10.2174/0115733998291920240611063402
Rama Rao Nadendla, Khairunnisa K, Namra Aziz, Chandana Pyne, Uttam Prasad Panigrahy, Pranay Wal, Mrunalini Harish Kulkarni, Azhar Rasheed
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Abstract

Background: Diabetic nephropathy (DN), the primary risk factor for end-stage kidney disease (ESKD) that requires dialysis or renal transplantation, affects up to 50% of individuals with diabetes.

Objective: In this article, potential mechanisms, biomarkers, and possible therapeutic targets will be discussed, as well as their interventional therapies.

Methods: A literature review was done from databases like Google Scholar, PUBMEDMEDLINE, and Scopus using standard keywords "Diabetic Nephropathy," "Biomarkers," "Pathophysiology," "Cellular Mechanism," "Cell Therapy," "Treatment Therapies" from 2010- 2023. It has been studied that metabolic as well as hemodynamic pathways resulting from hyperglycemia act as mediators for renal disease.

Results: We identified 270 articles, of which 210 were reviewed in full-text and 90 met the inclusion criteria. Every therapy regimen for the prevention and treatment of DN must include the blocking of ANG-II action. By reducing inflammatory and fibrotic markers brought on by hyperglycemia, an innovative approach to halting the progression of diabetic mellitus (DN) involves combining sodium-glucose cotransporter-2 inhibitors with renin-angiotensin-aldosterone system blockers. When compared to taking either medicine alone, this method works better. AGEs, protein kinase C (PKC), and the renin-angiotensin aldosterone system (RAAS) are among the components that are inhibited in DN management strategies.

Conclusion: Thus, it can be concluded that the multifactorial condition of DN needs to be treated at an early stage. Novel therapies with a combination of cell therapies and diet management are proven to be effective in the management of DN.

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糖尿病肾病最新综述:潜在机制、生物标记物、治疗目标和介入疗法。
背景:糖尿病肾病(DN糖尿病肾病(DN)是导致需要透析或肾移植的终末期肾病(ESKD)的主要风险因素,影响高达50%的糖尿病患者:本文将讨论潜在的机制、生物标志物、可能的治疗靶点及其干预疗法:方法:使用标准关键词 "糖尿病肾病"、"生物标志物"、"病理生理学"、"细胞机制"、"细胞疗法"、"治疗疗法",从谷歌学术、PUBMEDMEDLINE 和 Scopus 等数据库中查阅了 2010-2023 年间的文献。研究发现,高血糖导致的代谢和血液动力学途径是肾脏疾病的诱因:我们确定了 270 篇文章,对其中 210 篇进行了全文审阅,90 篇符合纳入标准。预防和治疗 DN 的所有治疗方案都必须包括阻断 ANG-II 的作用。通过减少高血糖引起的炎症和纤维化标志物,一种阻止糖尿病(DN)恶化的创新方法是将钠-葡萄糖共转运体-2抑制剂与肾素-血管紧张素-醛固酮系统阻断剂结合使用。与单独服用其中一种药物相比,这种方法效果更好。AGEs、蛋白激酶 C(PKC)和肾素-血管紧张素-醛固酮系统(RAAS)是 DN 管理策略中被抑制的成分:因此,可以得出结论,DN这种多因素疾病需要在早期阶段进行治疗。结合细胞疗法和饮食管理的新型疗法已被证明对治疗 DN 有效。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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