Contrast Sensitivity Better Reflects Wide-Field Swept-Source Optical Coherence Tomography Angiography Vascular Metrics Among Healthy Eyes Compared to Visual Acuity.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-09-01 Epub Date: 2024-06-01 DOI:10.3928/23258160-20240411-01

Grace Baldwin, Jack Tracy, Filippos Vingopoulos, Mary Munsell, Cade Bennett, Jocelyn Marie Rodriguez, Hanna Choi, Itika Garg, Rachel Tandias, Hannah Wescott, Matthew J Finn, Peyman Razavi, Augustine Bannerman, Rebecca Zeng, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller

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Abstract

Background and objective: To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.

Patients and methods: Fifty-seven eyes of 45 patients were evaluated with visual acuity (VA), contrast sensitivity (CS), and WF SS-OCTA (3 × 3, 6 × 6, and 12 × 12 mm images) on the same day. Mixed-effects multivariable regression analyses were performed.

Results: Contrast sensitivity metrics, including CS between 6 to 18 cycles per degree (cpd) and area under the logarithm CS function, were significantly associated with vessel density (VD) and vessel skeletonized density (VSD), whereas VA was not. The largest effect size was between CS at 18 cpd and VD (β = 0.41, P = 0.007) and VSD (β = 0.42, P = 0.006) on 12 × 12 mm images.

Conclusions: Reduced VSD and VD on WF SSOCTA was significantly associated with decreased CS, whereas VA was not. These results suggest CS could serve as a screening tool for early stage retinal and neurologic disorders. [Ophthalmic Surg Lasers Imaging Retina 2024;55:494-502.].

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与视力相比，对比敏感度能更好地反映健康眼睛的宽视场扫源光学相干断层扫描血管成像指标。

背景和目的：评估宽视场扫源光学相干断层血管成像（WF SS-OCTA）与健康眼睛视功能之间的关联：评估健康眼睛的宽视场扫源光学相干断层血管成像（WF SS-OCTA）与视功能之间的关联：在同一天对 45 名患者的 57 只眼睛进行视力 (VA)、对比敏感度 (CS) 和 WF SS-OCTA（3 × 3、6 × 6 和 12 × 12 mm 图像）评估。进行了混合效应多变量回归分析：对比敏感度指标，包括每度 6 至 18 个周期（cpd）的 CS 和 CS 对数函数下的面积，与血管密度（VD）和血管骨架密度（VSD）显著相关，而 VA 则不相关。在 12 × 12 毫米图像上，18 cpd 的 CS 与 VD（β = 0.41，P = 0.007）和 VSD（β = 0.42，P = 0.006）之间的效应大小最大：结论：WF SSOCTA 上 VSD 和 VD 的减少与 CS 的减少显著相关，而 VA 则不然。这些结果表明，CS 可作为早期视网膜和神经系统疾病的筛查工具。[眼科手术激光成像视网膜2024;55:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.