Ophthalmic surgery, lasers & imaging retina最新文献

Objective: This study aimed to evaluate characteristics of industry and public research payments for age-related macular degeneration studies.

Materials and methods: Studies involving "age-related macular degeneration" or "AMD" from 2015 to 2021 were extracted from the Open Payments Database and the National Eye Institute RePORTER tool and compared to each other.

Results: From 2015 to 2021, 620 ophthalmologists received $178,394,734.09 in industry research payments with a 76.9% increase from 2015 to 2020 and a subsequent 40.7% decrease in 2021. There were 84 female industry funding recipients (13.7%) compared to 528 (86.3%) male recipients (P < 0.001). For public funding, 119 ophthalmologists received $157,319,575.00 with a 31.0% increase from 2015 to 2021. Among 119 principal investigators, 37 (31.1%) were women and 82 (68.9%) were men (P = 0.05).

Conclusion: Industry-funded and publicly funded age-related macular degeneration-related research payments overall increased from 2015 to 2021. Funding distribution by sex trended towards male recipients. [Ophthalmic Surg Lasers Imaging Retina 2025;56:95-100.].

Background and objective: This study evaluated optometrists' referral patterns for epiretinal membrane (ERM) patients in Ontario, Canada, and their attitudes towards an artificial intelligence (AI) tool for improving referral accuracy. An anonymous online survey with 11 questions was conducted.

Patients and methods: The survey targeted optometrists across Ontario, Canada. The survey aimed to understand optometrists' reasons for referring ERM patients to retina specialists, their expectations of the specialists' management, and their openness to using an AI tool for triage. To prevent bias, the survey described an AI tool as an online consultation feature limited to predefined questions without directly mentioning "AI." The main objective was to assess if this AI tool could decrease unnecessary ERM referrals to retina specialists.

Results: A total of 135 optometrists participated. They reported seeing an average of eight ERM cases monthly, referring every fourth case to a specialist. The primary referral reason (84.3%) was to evaluate for surgery. In terms of referral confidence, 34.3% felt fully confident (5/5), and 47.8% slightly less so (4/5). They anticipated that 20% of patients would have a change in management post-consultation with a specialist. When introduced to the concept of an online consultation tool for patient screening, optometrists believed it could reduce their ERM referrals by 40%.

Conclusions: Optometrists often refer ERM patients to retina specialists. An AI tool for screening ERM referrals, based on presenting vision and OCT images, could significantly lower the number of unnecessary referrals, offering clinical guidance to optometrists. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

This report presents a case of a 22-year-old woman with bilateral giant choroidal caverns (CCs) in rod-cone dystrophy. Her best-corrected visual acuity was 20/80 in the right eye and 20/50 in the left eye. Fundus examination showed optic nerve pallor, narrowed blood vessels, and diffuse pigmentary changes. Fundus autofluorescence showed a central area of reduced autofluorescence surrounded by stippled autofluorescence. An electroretinogram showed decreased amplitude of both scotopic and photopic waves, consistent with a diagnosis of rod-cone dystrophy (retinitis pigmentosa). Optical coherence tomography revealed large CC and foveal atrophy in each eye. A giant CC alongside rod-cone dystrophy is a distinctive feature. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

This report presents cases of an unusual appearance of bilateral idiopathic multifocal retinal pigment epithelial detachments (PEDs) in three patients, using multimodal imaging. Three patients with multiple PEDs, initially diagnosed as drusen, were referred for evaluation. They underwent comprehensive ophthalmic examination and multimodal imaging. All patients had a best-corrected visual acuity of 6/6 in both eyes. Fundoscopy revealed multiple idiopathic PEDs in a miliary distribution, resembling crocodile skin. Systemic workup excluded associated diseases, though one patient was pregnant. The pathogenesis and progression are poorly understood, but prognosis is favorable without intervention unless complications arise. [Ophthalmic Surg Lasers Imaging Retina 2025;56:108-112.].

Background and objective: Janus kinase (Jak) inhibitors may have increased risk of thromboembolism compared to tumor necrosis factor (TNF) inhibitors. This study investigates the association between Jak inhibitor use and retinal vein occlusion.

Patients and methods: This retrospective, non-randomized cohort study used a federated health research network. Propensity-score matched risk ratios with 95% CI were calculated for central and branch retinal vein occlusion (CRVO, BRVO) in patients with immune-mediated inflammatory diseases (IMIDs) treated with Jak inhibitors versus TNF inhibitors.

Results: Jak and TNF inhibitor cohorts each had 5,249 patients. Risk ratio for CRVO with Jak inhibitors (n = 11) versus TNF inhibitors (n = 18) was 0.61 [CI (0.29,1.29)]. Risk ratio for BRVO with Jak inhibitors (n = 17) compared to TNF inhibitors (n = 19) was 0.89 [CI (0.47,1.72)].

Conclusion: This study did not find evidence of increased risk of RVO with the use of Jak inhibitors compared to TNF inhibitors among patients with IMIDs, contributing to literature on Jak inhibitor safety. [Ophthalmic Surg Lasers Imaging Retina 2025;56:72-78.].

A 27-year-old woman presented with bilateral blurry vision for 2 weeks. She had a presumed diagnosis of idiopathic intracranial hypertension given her bilateral disc edema; however, bilateral disc and retinal infiltration was noted on ophthalmoscopy. This report presents a rare case of chronic myelogenous leukemia (CML) in the non-blast phase presenting as bilateral optic disc infiltration, indicating central nervous system involvement at the time of diagnosis. The patient had no other clinical symptoms at the time of diagnosis and was promptly treated with orbital radiation and a tyrosine kinase inhibitor, resulting in 20/20 vision in both eyes. [Ophthalmic Surg Lasers Imaging Retina 2025;56:102-107.].

The objective of this study was to report the initial experiences of seven surgeons using a titanium macular buckle (TMB) for the treatment of myopic maculopathy. The records of 11 cases that underwent TMB placement, with or without concomitant vitrectomy, were reviewed. Collected data included demographics, type of maculopathy, pre-operative and postoperative ophthalmic findings. The intraoperative utilization of pars plana vitrectomy and any associated complications were also documented. The indications for surgery included posterior pole retinal detachment with maculoschisis, maculoschisis with an epiretinal membrane, myopic macular hole with posterior pole retinal detachment, isolated maculoschisis, and myopic macular hole. Eight of the 11 cases underwent combined titanium macular buckle placement and vitrectomy, while three patients received buckle placement without vitrectomy. Partial or complete resolution of the pathology was achieved in all cases. Best-corrected visual acuity improved in 10 out of 11 cases following surgery. A scleral perforation occurred intraoperatively in one case. The patients were followed up for a mean duration of 6.0 ± 2.3 months (range: 2 to 10 months). TMB may serve as a valuable adjunct in the surgical repair of myopic maculopathy requiring intervention. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

To identify real-world complications involving flanged scleral tunnel fixation of Zeiss CT Lucia 602 intraocular lenses, the Food and Drug Administration Manufacturer and User Facility Device Experience (FDA MAUDE) was searched by Manufacturer field for Zeiss with the terms "Yamane" and "scleral fixated". Reports containing these terms were reviewed to confirm technique and categorize adverse events. The search yielded 178 confirmed reports of lens malfunctions for CT Lucia 602 between 2013 to 2024, with 95% of reports in the last 3 years. The most common complication was lens tilt (94 reports), followed by breakage (53) comprised of haptic-optic disinsertion (31) and haptic breakage (22). Intraoperatively, 118 (66.3%) complications occurred, and 60 (33.7%) occurred postoperatively. Temporal analysis revealed that the number of reports to MAUDE has shown a ten-fold annual increase since 2020. Reports suggest haptic breakage is a noteworthy malfunction for CT Lucia 602 lenses. The occurrence of intraoperative breakage and lens tilt may be higher than previously expected in real-world settings. [Ophthalmic Surg Lasers Imaging Retina 2025;56:123-125.].