Ophthalmic surgery, lasers & imaging retina最新文献

Background and objective: Sickle cell disease (SCD) is a vascular disease that may affect the retina. This study aimed to evaluate differences in average velocity (AV, mm/s), blood flow (BF, μL/min) and vessel diameter (VD, μm) from the temporal retinal arcades in SCD compared to healthy eyes using Doppler optical coherence tomography (DOCT).

Patients and methods: A cross-sectional study was conducted between 2021 and 2023. The DOCT scan was located at the superior and inferior temporal vessel arcades of all subjects. Differences between the two groups were assessed.

Results: Thirty-nine healthy eyes and 36 SCD eyes were imaged. The median of AV, BF, and VD were 1.4, 2.5, and 1.3 times higher in SCD eyes compared to healthy eyes in the superotemporal arteries (P = 0.002, P = 5.0 × 10-3, P = 4.0 × 10-6, respectively). Similar findings were observed for superotemporal veins and inferotemporal veins.

Conclusion: Eyes with SCD eyes exhibited significantly elevated retinal vascular flow parameters compared to healthy eyes. [Ophthalmic Surg Lasers Imaging Retina 2025;56:XX-XX.].

Background and objective: To assess the efficacy of intravitreal aflibercept 8 mg in treating neovascular age-related macular degeneration (nAMD) in patients previously treated with faricimab.

Patients and methods: A retrospective study was conducted on nAMD patients with suboptimal response to faricimab injections who were switched to intravitreal aflibercept 8 mg. Visual acuity (VA) and optical coherence tomography features were evaluated.

Results: The study included 135 eyes from 85 patients who received an average of 7.4 (4) faricimab injections with a mean interval of 53 days, which decreased to 48 days by the 5th aflibercept 8 mg injection (P = 0.056). Mean VA at the time of switch was 63.9 (14.4) letters and was 65 (13.5) letters after four aflibercept 8 mg injections (P = 0.726). Mean central foveal thickness (CFT) at switch was 325 (104) µm which decreased to 272 (65) after four aflibercept 8 mg injections (P < 0.001). The incidence of intraretinal fluid and subretinal hemorrhage increased from 31.3% and 8.1% at switch to 52.2% and 21.7% (P = 0.029 and 0.004), respectively.

Conclusions: Switching from faricimab to aflibercept 8 mg did not result in interval extension or VA improvement. CFT decreased, but intraretinal fluid and subretinal hemorrhage increased. Further studies are warranted. [Ophthalmic Surg Lasers Imaging Retina 2025;56:xx-xx.].

Tractional retinoschisis (TRS) secondary to proliferative diabetic retinopathy (PDR) may be differentiated from tractional retinal detachment (TRD) by its characteristically nonprogressive course. The purpose of the current study was to describe the use of swept-source optical coherence tomography angiography (SS-OCTA) in the diagnosis and monitoring of TRS secondary to PDR. Retrospective, consecutive case series of patients with TRS secondary to PDR are featured. Clinical notes, fundus photography, and SS-OCTA images are reviewed. The study comprised three eyes of three patients with PDR and TRS. Visual acuity and anatomic features on SS-OCTA were stable in all patients at one year or more of follow-up. Tractional retinoschisis secondary to PDR is typically nonprogressive and may be observed without surgery. SS-OCTA serves as a noninvasive and effective imaging tool to distinguish TRS from TRD and to demonstrate anatomic stability over time. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].

This case report describes a new type of perifoveal retinal vascular abnormality (RVA) incidentally discovered during a posterior vitreous detachment (PVD) investigation. A 65-year-old woman with sudden central visual loss displayed a uni-lateral focal telangiectatic venule in the perifoveal area. Multimodal imaging documented the vascular abnormality and associated retinal changes. Despite symptom resolution, the RVA persisted. This case represents a unique presentation of perifoveal RVA, likely an atypical form of macular telangiectasia. The sequential imaging documentation during a process of PVD with central bouquet traction provides insights into the underlying mechanisms in addition to diagnosing and monitoring perifoveal RVAs. [Ophthalmic Surg Lasers Imaging Retina 2024;55:737-741.].