Incidence, healthcare resource utilization and costs of hospitalized patients with tick-borne encephalitis (TBE) in Italy

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES Ticks and Tick-borne Diseases Pub Date : 2024-06-24 DOI:10.1016/j.ttbdis.2024.102372

Renzo Scaggiante , Liliana Guadagni , Massimiliano Orso , Daniela d’Angela , Ciro Carrieri , Barbara Polistena , Federico Spandonaro , Ilaria Bertoldi , Andreas Pilz , Katharina Schley , Raffaella Iantomasi

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Abstract

Objective

Our study's objective was to assess the incidence trends and healthcare resource utilization of hospitalizations for Tick-Borne Encephalitis (TBE) and associated costs in Italy in order to improve public awareness and preventive measures.

Methods

This retrospective observational study was based on the Italian Ministry of Health's Hospital Discharge Record (HDR) database. Data were gathered across Italy from 2015 to 2019, selecting hospitalizations with ICD-9 code 063 related to TBE, both in primary and secondary diagnoses. For each year, we collected the following variables: number of hospitalizations, hospitalization rate, mortality rate, mean length of hospital stay, hospital ward, and cost of hospitalization.

Results

There were a total of 237 hospitalizations from 2015 to 2019; 62 % of those were male. The lowest number of TBE hospitalizations was in 2015 (21 cases, corresponding to 0.35 per million inhabitants), the highest in 2019 (64 cases, 1.04 per million inhabitants). The summer months saw a greater than average number of hospitalizations. For the years analyzed, the cumulative number of cases peaked in June (54 cases), July (46 cases), and August (35 cases). There were only two deaths registered in our study sample. TBE cases were mostly localized in the North-Eastern regions of Italy. TBE incidence during the study period in the most affected areas were: Autonomous Province of Trento, ranging from 11.2 to 42.3 per million inhabitants, Autonomous Province of South Tyrol, from 0 to 21.1 per million inhabitants, and Veneto Region, from 2.6 to 4.5 per million inhabitants. In the study period, the average length of hospital stay was largely stable ranging from 10.6 days to 12.8 days, with related costs ranging from 5,813.7 € to 7,352.5 €.

Conclusions

According to our data, the majority of TBE hospitalizations occur in North-East Italy with an increasing trend over the analyzed period. Even though Italy has fewer TBE cases than other neighboring European countries, the health and economic impact can be high in the affected areas.

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意大利蜱传脑炎 (TBE) 住院患者的发病率、医疗资源利用率和费用。

研究目的我们的研究旨在评估意大利蜱传脑炎（TBE）的发病趋势、住院医疗资源利用情况及相关费用，以提高公众意识并改进预防措施：这项回顾性观察研究基于意大利卫生部的出院记录（HDR）数据库。从 2015 年到 2019 年，我们在意大利各地收集了数据，选择了与结核病相关的 ICD-9 编码 063 的住院病例，包括主要诊断和辅助诊断。我们收集了每年的以下变量：住院人数、住院率、死亡率、平均住院时间、病房和住院费用：从 2015 年到 2019 年，共有 237 例住院，其中 62% 为男性。肺结核住院人数最少的是 2015 年（21 例，相当于每百万居民 0.35 例），最多的是 2019 年（64 例，每百万居民 1.04 例）。夏季的住院人数高于平均水平。在所分析的年份中，累计病例数在 6 月（54 例）、7 月（46 例）和 8 月（35 例）达到高峰。在我们的研究样本中，只有两例死亡病例。肺结核病例主要分布在意大利东北部地区。研究期间，受影响最严重地区的结核病发病率为特伦托自治省的发病率从每百万居民 11.2 例到 42.3 例不等，南蒂罗尔自治省的发病率从每百万居民 0 例到 21.1 例不等，威尼托大区的发病率从每百万居民 2.6 例到 4.5 例不等。在研究期间，平均住院时间基本稳定，从 10.6 天到 12.8 天不等，相关费用从 5813.7 欧元到 7352.5 欧元不等：根据我们的数据，大多数 TBE 住院病例发生在意大利东北部，并且在分析期间呈上升趋势。尽管意大利的肺结核病例少于其他欧洲邻国，但对疫区的健康和经济影响却很大。

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来源期刊

Ticks and Tick-borne Diseases INFECTIOUS DISEASES-MICROBIOLOGY

CiteScore

6.90

自引率

12.50%

发文量

185

审稿时长

6-12 weeks

期刊介绍： Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials. The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.