Temperature-Dependent Luminescence of Nd3+-Doped Carbon Nanodots for Nanothermometry

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-06-27 DOI:10.1021/acsami.4c07605

Cecilia Wetzl, Carlos Renero-Lecuna, Lucia Cardo*, Luis M. Liz-Marzán and Maurizio Prato*,

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Abstract

Noncontact optical nanothermometers operating within the biological transparency windows are required to study temperature-sensitive biological phenomena at the nanoscale. Nanoparticles containing rare-earth ions such as Nd³⁺ have been reported to be efficient luminescence-based ratiometric thermometers, however often limited by poor water solubility and concentration-related quenching effects. Herein, we introduce a new type of nanothermometer, obtained by employing low-dimensional carbon nanodots (CNDs) as matrices to host Nd³⁺ ions (NdCNDs). By means of a one-pot procedure, small (∼7–12 nm), water-soluble nanoparticles were obtained, with high (15 wt %) Nd³⁺ loading. This stable metal-CND system features temperature-dependent photoluminescence in the second biological window (BW II) upon irradiation at 808 nm, thereby allowing accurate and reversible (heating/cooling) temperature measurements with good sensitivity and thermal resolution. The system possesses remarkable biocompatibility in vitro and promising performance at a high penetration depth in tissue models.

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用于纳米温度测量的掺钕碳纳米点的温度依赖性发光。

要在纳米尺度上研究对温度敏感的生物现象，就需要在生物透明窗口内工作的非接触式光学纳米温度计。据报道，含有稀土离子（如 Nd3+）的纳米粒子是高效的基于发光的比率温度计，但往往受到水溶性差和浓度相关淬灭效应的限制。在此，我们介绍一种新型纳米温度计，它采用低维碳纳米点（CNDs）作为基质来承载 Nd3+ 离子（NdCNDs）。通过一锅程序，获得了具有高（15 wt %）Nd3+负载的水溶性小纳米颗粒（7∼12 nm）。这种稳定的金属-CND 系统在 808 纳米波长的照射下，在第二个生物窗口（BW II）发出随温度变化的光致发光，从而可以进行精确、可逆（加热/冷却）的温度测量，并具有良好的灵敏度和热分辨率。该系统在体外具有出色的生物相容性，在组织模型中的高穿透深度性能良好。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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