The effectiveness of multidisciplinary weight loss interventions is associated with initial cardiorespiratory fitness in adolescents with obesity

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-06-23 DOI:10.1111/ijpo.13147

Brahim Allali, Bruno Pereira, Alicia Fillon, Lili Pouele, Julie Masurier, Charlotte Cardenoux, Laurie Isacco, Yves Boirie, Martine Duclos, David Thivel, Valérie Julian

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Abstract

Background

The identification of predictive parameters of the success of multidisciplinary weight loss interventions (MWLI) appears essential to optimize obesity management. The association between baseline cardiorespiratory fitness (CRF) and changes in anthropometric parameters and body composition during MWLI remains underexplored in adolescents with obesity.

Objectives

To assess whether baseline CRF was associated with the effectiveness of a 16-week MWLI measured through improved body mass, body mass index (BMI) and body composition (percentage of total fat mass (FM) as the main criterion).

Methods

Cardiorespiratory fitness and body composition were respectively measured by peak oxygen consumption (VO_2peak) during maximal exercise tests and dual-photon x-ray absorptiometry (DXA), before (T0) and after (T1) a 16-week MWLI in 165 adolescents (aged 13.3 ± 1.38 years, 61.2% female, BMI 35.11 ± 5.16 kg/m²).

Results

Reductions in BMI and total FM percentage between T0 and T1 were greater in subjects with a baseline VO_2peak ≥ 3rd quartile compared to the first quartile (p < 0.001) and the interquartile range (p < 0.05 and p < 0.001, respectively). Baseline VO_2peak and VO₂ at the first ventilator threshold were positively correlated with the reductions in body mass, BMI and total and visceral FM percentages and with the increase in lean mass (LM) percentage between T0 and T1 after adjustment for age and gender (p < 0.001).

Conclusion

Initial CRF is associated with the success of MWLI in adolescents with obesity. Improving their aerobic fitness before starting a MWLI might be a promising strategy to optimize its benefits.

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多学科减肥干预的有效性与肥胖青少年最初的心肺功能有关。

背景：确定多学科减肥干预（MWLI）成功的预测参数似乎对优化肥胖管理至关重要。在肥胖症青少年中，基线心肺功能（CRF）与多学科减肥干预期间人体测量参数和身体成分变化之间的关系仍未得到充分探讨：评估基线CRF是否与为期16周的MWLI的有效性相关，MWLI通过改善体重、体重指数（BMI）和身体成分（以总脂肪量百分比（FM）为主要标准）来衡量：方法：分别在 165 名青少年（年龄为 13.3 ± 1.38 岁，61.2% 为女性，体重指数为 35.11 ± 5.16 kg/m2）进行为期 16 周的小量运动疗法之前（T0）和之后（T1），通过最大运动测试期间的峰值耗氧量（VO2peak）和双光子 X 射线吸收测定法（DXA）测量他们的心肺功能和身体成分：结果：与第一四分位数相比，基线 VO2 峰值≥第三四分位数的受试者在 T0 和 T1 之间 BMI 和总 FM 百分比的降低幅度更大（p 2 峰值和首次呼吸机阈值时的 VO2 与体重、BMI、总 FM 百分比和内脏 FM 百分比的降低以及 T0 和 T1 之间瘦体重（LM）百分比的增加呈正相关，调整年龄和性别后（p 结论：最初的 CRF 与治疗相关：最初的 CRF 与肥胖青少年的 MWLI 成功与否有关。在开始进行有氧运动前提高他们的有氧体能可能是优化有氧运动益处的一个有前途的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.