Responses of zebra and quagga mussels to copper and tribytiltin exposure: Bioconcentration, metabolic and cardiac biomarkers

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-06-24 DOI:10.1016/j.cbpc.2024.109967
Nadezhda A. Berezina , Andrey N. Sharov , Victoria V. Yurchenko , Alexey A. Morozov , Olga A. Malysheva , Galina I. Kukhareva , Zoya A. Zhakovskaya
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Abstract

One of the top ecological priorities is to find sensitive indicators for pollution monitoring. This study focuses on the bioconcentration and responses (condition index, survival, oxygen consumption, heart rates, and oxidative stress and neurotoxic effect biomarkers) of mussels from the Volga River basin, Dreissena polymorpha and Dreissena bugensis, to long-term exposure to toxic chemicals such as tributyltin (TBT, 25 and 100 ng/L) and copper (Cu, 100 and 1000 μg/L). We found that TBT was present in the tissues of zebra and quagga mussels in comparable amounts, whereas the bioconcentration factor of Cu varied depending on its concentration in water. Differences in responses between the two species were revealed. When exposed to high Cu concentrations or a Cu-TBT mixture, quagga mussels had a lower survival rate and a longer heart rate recovery time than zebra mussels. TBT treatment caused neurotoxicity (decreased acetylcholinesterase activity) and oxidative stress (increased levels of thiobarbituric acid reactive substances) in both species. TBT and Cu levels in mussel tissues correlated positively with the condition index, but correlated with the level of acetylcholinesterase in the mussel gills. The principal component analysis revealed three main components: the first consists of linear combinations of 14 variables reflecting TBT water pollution, TBT and Cu levels in mussel tissues, and biochemical indicators; the second includes Cu water concentration, cardiac tolerance, and mussel size; and the third combines weight, metabolic rate, and heart rates. Quagga mussels are less tolerable to contaminants than zebra mussels, so they may be used as a sensitive indicator.

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斑马贻贝和夸加贻贝对铜和三氯锡接触的反应:生物浓缩、新陈代谢和心脏生物标志物。
生态学的首要任务之一是找到污染监测的敏感指标。本研究的重点是伏尔加河流域的贻贝 Dreissena polymorpha 和 Dreissena bugensis 长期暴露于三丁基锡(TBT,25 和 100 ng/L)和铜(Cu,100 和 1000 μg/L)等有毒化学物质后的生物浓缩和反应(状态指数、存活率、耗氧量、心率以及氧化应激和神经毒性效应生物标志物)。我们发现,三丁基锡化合物在斑马贻贝和夸加贻贝组织中的含量相当,而铜的生物富集因子则因其在水中的浓度而异。两种贻贝的反应存在差异。当接触高浓度铜或铜-三丁基锡化合物混合物时,斑马贻贝的存活率较低,心率恢复时间较长。三丁基锡化合物处理会对两种贻贝造成神经毒性(乙酰胆碱酯酶活性降低)和氧化应激(硫代巴比妥酸活性物质水平升高)。贻贝组织中三丁基锡化合物和铜的含量与状态指数呈正相关,但与贻贝鳃中乙酰胆碱酯酶的含量呈负相关。主成分分析显示了三个主要成分:第一个成分由 14 个变量的线性组合组成,这些变量反映了三丁基锡化合物水污染、贻贝组织中的三丁基锡化合物和铜含量以及生化指标;第二个成分包括铜水浓度、心脏耐受力和贻贝大小;第三个成分由体重、代谢率和心率组成。夸加贻贝对污染物的耐受性不如斑马贻贝,因此可将其作为敏感指标。
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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