The effects of ursolic acid on cardiometabolic risk factors: a systematic review and meta-analysis.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2024-01-01 Epub Date: 2024-05-29 DOI:10.1080/14796678.2024.2349476
Pegah Rafiee, Niloufar Rasaei, Mohammad Reza Amini, Reyhaneh Rabiee, Zahra Kalantar, Fatemeh Sheikhhossein, Mohammad Gholizadeh, Azita Hekmatdoost
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Abstract

Aim: Ursolic acid (UA) has an important biological role in the fight against fat accumulation, insulin resistance, obesity and inflammation. Therefore, in the current review and meta-analysis work, we investigate the effects of UA (dosage range is 50.94 to 450 mg/day) on cardiometabolic risk factors. Materials & methods: After searching the studies up to February 2023, six articles were included in the study. Results: The pooled effect size showed that UA supplementation didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride and high-density lipoprotein compared with control groups. Conclusion: UA supplementation had no significant effect on the cardiometabolic risk factors in adults.

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熊果酸对心脏代谢风险因素的影响:系统综述和荟萃分析。
目的:熊果酸(UA)在对抗脂肪堆积、胰岛素抵抗、肥胖和炎症方面具有重要的生物学作用。因此,在目前的综述和荟萃分析工作中,我们研究了 UA(剂量范围为 50.94 至 450 毫克/天)对心脏代谢风险因素的影响。材料与方法:检索截至 2023 年 2 月的研究,共纳入 6 篇文章。研究结果汇总效应大小显示,与对照组相比,补充尿酸不会显著改变体重、体重指数、腰围、体脂率、瘦体重、收缩压、舒张压、空腹血糖、胰岛素、甘油三酯和高密度脂蛋白。结论是补充尿酸对成年人的心脏代谢风险因素没有明显影响。
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来源期刊
Future cardiology
Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.80
自引率
5.90%
发文量
87
期刊介绍: Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.
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