Edward W Odell, Carolina Cavalieri Gomes, Selvam Thavaraj
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引用次数: 0
Abstract
Adenoid ameloblastoma (AA) was recently recognised as a separate tumour type in the most recent World Health Organisation (WHO) classification of head and neck tumours. This decision has been considered controversial by several groups, who have described AA as a subtype of ameloblastoma, a hybrid odontogenic tumour or to fall within the spectrum of other recognised odontogenic tumours, including dentinogenic ghost cell tumour and adenomatoid odontogenic tumour. Here we review the reasons for the WHO decision to classify AA as a separate tumour type. We also critique molecular and histological findings from recent reports published since the WHO classification. While acknowledging that the classification of tumours is constantly evolving, the balance of current evidence suggests that AA should remain a distinct tumour type, and not a subtype of ameloblastoma, pending further molecular characterisation.
最近,在世界卫生组织(WHO)最新的头颈部肿瘤分类中,腺样釉母细胞瘤(AA)被认定为一种独立的肿瘤类型。这一决定引起了一些团体的争议,他们认为AA是釉母细胞瘤的一种亚型、一种混合性牙源性肿瘤,或者属于其他公认的牙源性肿瘤,包括牙本质鬼细胞瘤和腺瘤样牙源性肿瘤。在此,我们回顾了世界卫生组织决定将 AA 划分为单独肿瘤类型的原因。我们还对世卫组织分类后发表的最新报告中的分子和组织学发现进行了点评。我们承认肿瘤的分类在不断发展,但目前的证据表明,AA仍应是一个独立的肿瘤类型,而不是釉母细胞瘤的一个亚型,有待进一步的分子鉴定。
期刊介绍:
Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.