CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression

IF 4.9 3区 医学 Q2 IMMUNOLOGY Immunology Pub Date : 2024-06-23 DOI:10.1111/imm.13825
Marcos S. Cardoso, Rute Gonçalves, Liliana Oliveira, Diogo Silvério, Érica Téllez, Tony Paul, Maria Rosa Sarrias, Alexandre M. Carmo, Margarida Saraiva
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Abstract

Tuberculosis (TB) alone caused over a billion deaths in the last 200 years, making it one of the deadliest diseases to humankind. Understanding the immune mechanisms underlying protection or pathology in TB is key to uncover the much needed innovative approaches to tackle TB. The scavenger receptor cysteine-rich molecule CD5 antigen-like (CD5L) has been associated with TB, but whether and how CD5L shapes the immune response during the course of disease remains poorly understood. Here, we show an upregulation of CD5L in circulation and at the site of infection in C57BL/6 Mycobacterium tuberculosis-infected mice. To investigate the role of CD5L in TB, we studied the progression of M. tuberculosis aerosol infection in a recently described genetically engineered mouse model lacking CD5L. Despite the increase of CD5L during infection of wild-type mice, absence of CD5L did not impact bacterial burden, histopathology or survival of infected mice. Absence of CD5L associated with a modest increase in the numbers of CD4+ T cells and the expression of IFN-γ in the lungs of infected mice, with no major effect in overall immune cell dynamics. Collectively, this study confirms CD5L as a potential diagnostic biomarker to TB, showing no discernible impact on the outcome of the infection.

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CD5L 在感染结核分枝杆菌后上调,但对疾病进展没有影响。
在过去的 200 年里,仅结核病(TB)就造成了 10 亿多人死亡,使其成为人类最致命的疾病之一。了解结核病的保护或病理基础免疫机制是找到解决结核病急需的创新方法的关键。清道夫受体富半胱氨酸分子 CD5 抗原样(CD5L)与肺结核有关,但 CD5L 是否以及如何在疾病过程中影响免疫反应仍鲜为人知。在这里,我们发现 CD5L 在 C57BL/6 结核分枝杆菌感染小鼠的血液循环和感染部位上调。为了研究 CD5L 在结核病中的作用,我们在最近描述的缺乏 CD5L 的基因工程小鼠模型中研究了结核杆菌气溶胶感染的进展。尽管 CD5L 在野生型小鼠感染过程中会增加,但 CD5L 的缺失不会影响细菌负荷、组织病理学或感染小鼠的存活率。CD5L 的缺失会导致受感染小鼠肺部 CD4+ T 细胞数量和 IFN-γ 表达的适度增加,但对整体免疫细胞动态并无重大影响。总之,这项研究证实 CD5L 是一种潜在的结核病诊断生物标志物,对感染结果没有明显影响。
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来源期刊
Immunology
Immunology 医学-免疫学
CiteScore
11.90
自引率
1.60%
发文量
175
审稿时长
4-8 weeks
期刊介绍: Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.
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