How Does the Burden of Respiratory Syncytial Virus Compare to Influenza in Spanish Adults?

IF 4.3 4区 医学 Q1 INFECTIOUS DISEASES Influenza and Other Respiratory Viruses Pub Date : 2024-06-24 DOI:10.1111/irv.13341
Federico Martinón-Torres, Clara Gutierrez, Ana Cáceres, Karin Weber, Antoni Torres
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Abstract

Background

Respiratory syncytial virus (RSV) and influenza infections cause significant annual morbidity and mortality worldwide in at-risk populations. This study is aimed at assessing hospital burden and healthcare resource utilization (HRU) of RSV and influenza in adults in Spain.

Methods

Data were obtained from the Projected Hospitalisation Database of inpatient episodes (ages: younger adults 18–50 and 51–64 years; older adults 65–74, 75–84, and ≥ 85 years) during 2015, 2017, and 2018 in Spanish public hospitals. Incidence, mean hospitalization, and HRU assessments, including length of stay (LOS), intensive care unit (ICU) usage, and age-standardized mortality rates, were collected and stratified by age group, with analyses focusing on the adult population (≥ 18 years old).

Results

Mean hospitalization rate in the population across all years was lower in individuals with RSV versus influenza (7.2/100,000 vs. 49.7/100,000 individuals). ICU admissions and median LOS were similar by age group for both viruses. Age-standardized mortality was 6.3/100,000 individuals and 6.1/100,000 individuals in patients with RSV and influenza, respectively, and mortality rates were similar in older adults (≥ 65 years) for both viruses.

Conclusions

RSV and influenza infection were associated with considerable HRU. There is a substantial disease burden for RSV infection in older adults ≥ 65 years. While RSV hospitalization rates in adults reported here appeared lower than influenza, RSV is still underdiagnosed in the hospital setting and its incidence might be similar to, or higher than, influenza.

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在西班牙成年人中,呼吸道合胞病毒的负担与流感相比如何?
背景:呼吸道合胞病毒(RSV)和流感感染每年都会在全球高危人群中造成严重的发病率和死亡率。本研究旨在评估西班牙成人感染 RSV 和流感的医院负担和医疗资源利用率(HRU):数据来自西班牙公立医院 2015、2017 和 2018 年住院病例预测数据库(年龄:18-50 岁和 51-64 岁的年轻成年人;65-74 岁、75-84 岁和≥85 岁的老年人)。收集了发病率、平均住院率和 HRU 评估,包括住院时间(LOS)、重症监护室(ICU)使用率和年龄标准化死亡率,并按年龄组进行了分层,分析重点是成年人群(≥ 18 岁):结果:与流感相比,RSV患者在所有年份的平均住院率较低(7.2/100,000 对 49.7/100,000)。两种病毒在不同年龄组的重症监护室入院率和中位住院日相似。RSV和流感患者的年龄标准化死亡率分别为6.3/100,000和6.1/100,000,两种病毒在老年人(≥65岁)中的死亡率相似:结论:RSV 和流感感染与相当大的 HRU 有关。在年龄≥ 65 岁的老年人中,RSV 感染造成了巨大的疾病负担。虽然报告的成人 RSV 住院率似乎低于流感,但在医院环境中,RSV 的诊断率仍然偏低,其发病率可能与流感相似或更高。
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来源期刊
CiteScore
7.20
自引率
4.50%
发文量
120
审稿时长
6-12 weeks
期刊介绍: Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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