Efficacy of a RADA-16 peptide hydrogel versus chitosan-based polymer in improving patient comfort during postoperative debridement: A randomized controlled trial

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY International Forum of Allergy & Rhinology Pub Date : 2024-06-27 DOI:10.1002/alr.23395

Kevin Hur MD, Amila Adili MPH, Benjamin Tam BA, Kevin Herrera BS, Aditi Agarwal MBBS, Dale Rice MD, Elisabeth Ference MD, MPH, Bozena Wrobel MD, David Conley MD

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Abstract

Background

Bioresorbable nasal packing is associated with a decreased incidence of adhesions and bleeding postoperatively after endoscopic sinus surgery (ESS). However, discomfort during postoperative debridement is still a major area of concern for patients. Our objective was to compare the efficacy of a peptide hydrogel to that of a chitosan-based polymer in reducing pain during debridement after ESS.

Methods

A prospective, multicenter, randomized, blinded trial was conducted in adults undergoing bilateral total ethmoidectomy for chronic rhinosinusitis. Participants served as their own controls with each subject receiving the hydrogel in a randomized ethmoid cavity and chitosan-based polymer in the contralateral ethmoid cavity. Participants were evaluated at 1, 4, and 12 weeks postoperatively. Pain during debridement as well as endoscopic evaluation of mucosal healing and hemostasis were measured.

Results

Thirty patients who underwent ESS were included in this trial. During the week 1 postoperative debridement, patients reported significantly less pain on the hydrogel-treated side compared to the chitosan-based polymer-treated side. There were no significant differences in bleeding severity, Lund–Kennedy scores, debridement time, or need for further intervention between the two groups.

Conclusion

This study demonstrated the efficacy of a peptide hydrogel in minimizing pain during postoperative debridement.

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RADA-16 肽水凝胶与壳聚糖聚合物在改善术后清创期间患者舒适度方面的功效：随机对照试验。

背景：生物可吸收鼻腔填料可降低内窥镜鼻窦手术（ESS）术后粘连和出血的发生率。然而，术后清创过程中的不适感仍是患者关注的主要问题。我们的目的是比较多肽水凝胶和壳聚糖聚合物在减轻ESS术后清创过程中疼痛的效果：我们对因慢性鼻炎接受双侧乙状结肠全切除术的成人进行了一项前瞻性、多中心、随机、盲法试验。受试者作为自己的对照组，每个受试者在随机的乙状结肠腔中接受水凝胶，在对侧乙状结肠腔中接受壳聚糖基聚合物。参与者在术后 1 周、4 周和 12 周接受评估。对清创时的疼痛以及粘膜愈合和止血的内窥镜评估进行了测量：30名接受ESS手术的患者参与了此次试验。在术后第 1 周的清创过程中，与壳聚糖基聚合物处理的一侧相比，水凝胶处理的一侧患者的疼痛明显减轻。两组患者在出血严重程度、伦德-肯尼迪评分、清创时间或是否需要进一步干预方面没有明显差异：这项研究证明了多肽水凝胶在减轻术后清创疼痛方面的功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.