Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI:10.1111/odi.15046

Martina Coppini, Vito Carlo Alberto Caponio, Rodolfo Mauceri, Maria Eleonora Bizzoca, Luigi Laino, Alejandro I Lorenzo-Pouso, Diana Russo, Giuseppe Troiano, Fábio França Vieira E Silva, Lorenzo Lo Muzio, Giuseppina Campisi

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Abstract

Background: Oral mucositis (OM) is considered one of the most common side effects of patients undergoing cancer therapy. OM prevention plays a crucial role in the effectiveness of cancer treatment and the patient's quality of life. Different preventive treatments have been proposed in clinical trials, however with inconclusive results.

Materials and methods: A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: in cancer patients, do specific topical agents compared to standard treatments or placebo reduce the onset and severity of oral mucositis? The risk of bias was assessed, and a network meta-analysis was conducted.

Results: Of 2913 results, 30 randomized clinical trials were considered suitable for inclusion. A total of 2564 patients were analyzed, of which 1284 belonged to the test group and 1280 belonged to the control group. Natural products were the most used, followed mainly by antimicrobial agents, coating agents, and basic oral care measures. Topical sucralfate resulted in the most powerful intervention for the OM prevention (OR = 0.04, 95%C.I. = 0.01-0.25, p-value = 0.001).

Conclusion: Due to its cytoprotective action, low cost, ease of administration, and safety, sucralfate could become a potential ally to prevent the onset of OM during cancer therapy.

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预防口腔黏膜炎的外用药物疗效：系统综述和网络荟萃分析。

背景：口腔黏膜炎（OM口腔黏膜炎（OM）被认为是接受癌症治疗的患者最常见的副作用之一。预防口腔黏膜炎对癌症治疗的效果和患者的生活质量起着至关重要的作用。临床试验中提出了不同的预防治疗方法，但结果并不一致：在 PubMed、Scopus、Web of Science 和 Cochrane 数据库中进行了系统综述检索，以回答 PICO 问题：在癌症患者中，与标准治疗或安慰剂相比，特定的外用药物是否能降低口腔黏膜炎的发生率和严重程度？对偏倚风险进行了评估，并进行了网络荟萃分析：在2913项研究结果中，有30项随机临床试验被认为适合纳入研究。共分析了2564名患者，其中1284人属于试验组，1280人属于对照组。使用最多的是天然产品，其次主要是抗菌剂、涂层剂和基本口腔护理措施。外用琥珀酸盐是预防口腔溃疡最有效的干预措施（OR = 0.04，95%C.I. = 0.01-0.25，p 值 = 0.001）：由于蔗糖酸钠具有细胞保护作用、成本低、用药方便且安全，它可能成为癌症治疗期间预防 OM 发生的潜在盟友。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.