Is exposure to pesticides associated with biological aging? A systematic review and meta-analysis

IF 12.5 1区医学 Q1 CELL BIOLOGY Ageing Research Reviews Pub Date : 2024-06-24 DOI:10.1016/j.arr.2024.102390

Shanshan Zuo , Vidhya Sasitharan , Gian Luca Di Tanna , Judith M. Vonk , Maaike De Vries , Moustafa Sherif , Balázs Ádám , Juan Carlos Rivillas , Valentina Gallo

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Abstract

Objective

Exposure to pesticides is a risk factor for various diseases, yet its association with biological aging remains unclear. We aimed to systematically investigate the relationship between pesticide exposure and biological aging.

Methods

PubMed, Embase and Web of Science were searched from inception to August 2023. Observational studies investigating the association between pesticide exposure and biomarkers of biological aging were included. Three-level random-effect meta-analysis was used to synthesize the data. Risk of bias was assessed by the Newcastle-Ottawa Scale.

Results

Twenty studies evaluating the associations between pesticide exposure and biomarkers of biological aging in 10,368 individuals were included. Sixteen reported telomere length and four reported epigenetic clocks. Meta-analysis showed no statistically significant associations between pesticide exposure and the Hannum clock (pooled β = 0.27; 95 %CI: −0.25, 0.79), or telomere length (pooled Hedges’g = −0.46; 95 %CI: −1.10, 0.19). However, the opposite direction of effects for the two outcomes showed an indication of possible accelerated biological aging. After removal of influential effect sizes or low-quality studies, shorter telomere length was found in higher-exposed populations.

Conclusion

The existing evidence for associations between pesticide exposure and biological aging is limited due to the scarcity of studies on epigenetic clocks and the substantial heterogeneity across studies on telomere length. High-quality studies incorporating more biomarkers of biological aging, focusing more on active chemical ingredients of pesticides and accounting for potential confounders are needed to enhance our understanding of the impact of pesticides on biological aging.

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接触杀虫剂与生物衰老有关吗？系统回顾和荟萃分析。

目的：接触杀虫剂是多种疾病的风险因素之一，但其与生物衰老的关系仍不清楚。我们旨在系统地研究农药暴露与生物衰老之间的关系：方法：检索了从开始到 2023 年 8 月的 PubMed、Embase 和 Web of Science。纳入了调查农药暴露与生物衰老生物标志物之间关系的观察性研究。采用三级随机效应荟萃分析法对数据进行综合分析。采用纽卡斯尔-渥太华量表评估偏倚风险：结果：共纳入了 20 项研究，评估了 10,368 人的农药暴露与生物衰老生物标志物之间的关系。其中 16 项报告了端粒长度，4 项报告了表观遗传时钟。Meta 分析表明，农药暴露与 Hannum 时钟（汇总 β = 0.27；95%CI：-0.25，0.79）或端粒长度（汇总 Hedges'g = -0.46；95%CI：-1.10，0.19）之间没有统计学意义上的显著关联。然而，这两项结果的效应方向相反，表明生物衰老可能加速。在剔除影响效应大小或低质量的研究后，发现端粒长度较短的是暴露程度较高的人群：结论：由于有关表观遗传时钟的研究很少，而且端粒长度的研究之间存在很大的异质性，因此有关农药暴露与生物衰老之间关系的现有证据很有限。为了加深我们对农药对生物衰老的影响的理解，我们需要进行高质量的研究，纳入更多生物衰老的生物标志物，更多地关注农药的活性化学成分，并考虑潜在的混杂因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.