Application of modern synthetic biology technology in aromatic amino acids and derived compounds biosynthesis

IF 9.7 1区环境科学与生态学 Q1 AGRICULTURAL ENGINEERING Bioresource Technology Pub Date : 2024-06-26 DOI:10.1016/j.biortech.2024.131050

Mi Tang , Jiajia You , Tianjin Yang , Qisheng Sun , Shuran Jiang , Meijuan Xu , Xuewei Pan , Zhiming Rao

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Abstract

Aromatic amino acids (AAA) and derived compounds have enormous commercial value with extensive applications in the food, chemical and pharmaceutical fields. Microbial production of AAA and derived compounds is a promising prospect for its environmental friendliness and sustainability. However, low yield and production efficiency remain major challenges for realizing industrial production. With the advancement of synthetic biology, microbial production of AAA and derived compounds has been significantly facilitated. In this review, a comprehensive overview on the current progresses, challenges and corresponding solutions for AAA and derived compounds biosynthesis is provided. The most cutting-edge developments of synthetic biology technology in AAA and derived compounds biosynthesis, including CRISPR-based system, genetically encoded biosensors and synthetic genetic circuits, were highlighted. Finally, future prospects of modern strategies conducive to the biosynthesis of AAA and derived compounds are discussed. This review offers guidance on constructing microbial cell factory for aromatic compound using synthetic biology technology.

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现代合成生物学技术在芳香族氨基酸及其衍生化合物生物合成中的应用

芳香族氨基酸（AAA）及其衍生化合物具有巨大的商业价值，在食品、化工和制药领域有着广泛的应用。微生物生产 AAA 及其衍生化合物因其环境友好性和可持续性而前景广阔。然而，低产量和生产效率仍然是实现工业化生产的主要挑战。随着合成生物学的发展，AAA 及其衍生化合物的微生物生产得到了极大的促进。本综述全面概述了 AAA 及其衍生化合物生物合成的当前进展、挑战和相应的解决方案。重点介绍了 AAA 及其衍生化合物生物合成领域最前沿的合成生物学技术发展，包括基于 CRISPR 的系统、基因编码生物传感器和合成基因电路。最后，讨论了有利于 AAA 及其衍生化合物生物合成的现代战略的未来前景。本综述为利用合成生物学技术构建芳香化合物的微生物细胞工厂提供了指导。

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来源期刊

Bioresource Technology 工程技术-能源与燃料

CiteScore

20.80

自引率

19.30%

发文量

2013

审稿时长

12 days

期刊介绍： Bioresource Technology publishes original articles, review articles, case studies, and short communications covering the fundamentals, applications, and management of bioresource technology. The journal seeks to advance and disseminate knowledge across various areas related to biomass, biological waste treatment, bioenergy, biotransformations, bioresource systems analysis, and associated conversion or production technologies. Topics include: • Biofuels: liquid and gaseous biofuels production, modeling and economics • Bioprocesses and bioproducts: biocatalysis and fermentations • Biomass and feedstocks utilization: bioconversion of agro-industrial residues • Environmental protection: biological waste treatment • Thermochemical conversion of biomass: combustion, pyrolysis, gasification, catalysis.