Lingzhi Cao, Xinjian Yang*, Yimei Li, Yang Yang, Qiulin Liu, Massimo Bottini, Yi Jin*, Bei Wang, Jinchao Zhang* and Xing-jie Liang*,
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引用次数: 0
Abstract
Tumor metastasis remains a major challenge in cancer management. Among various treatment strategies, immune cell-based cancer therapy holds a great potential for inhibiting metastasis. However, its wide application in cancer therapy is restricted by complex preparations, as well as inadequate homing and controllability. Herein, we present a groundbreaking approach for bioorthogonally manipulating tumor-NK (natural killer) cell assembly to inhibit tumor metastasis. Multiple dibenzocyclootyne (DBCO) groups decorated long single-stranded DNA were tail-modified on core–shell upconversion nanoparticles (CSUCNPs) and condensed by photosensitive chemical linker (PC-Linker) DNA to shield most of the DBCO groups. On the one hand, the light-triggered DNA scaffolds formed a cross-linked network by click chemistry, effectively impeding tumor cell migration. On the other hand, the efficient cellular assembly facilitated the effective communication between tumor cells and NK-92 cells, leading to enhanced immune response against tumors and further suppression of tumor metastasis. These features make our strategy highly applicable to a wide range of metastatic cancers.
肿瘤转移仍然是癌症治疗的一大挑战。在各种治疗策略中,基于免疫细胞的癌症疗法在抑制转移方面具有巨大潜力。然而,其在癌症治疗中的广泛应用受制于复杂的制备方法以及不充分的归巢性和可控性。在此,我们提出了一种开创性的生物正交操纵肿瘤-NK(自然杀伤)细胞集结以抑制肿瘤转移的方法。在核壳上转换纳米粒子(CSUCNPs)上尾部修饰了装饰长单链DNA的多个二苯并环羰基(DBCO)基团,并通过光敏化学连接体(PC-Linker)DNA凝结以屏蔽大部分DBCO基团。一方面,光诱导 DNA 支架通过点击化学反应形成交联网络,有效阻止肿瘤细胞迁移。另一方面,高效的细胞组装促进了肿瘤细胞与 NK-92 细胞之间的有效交流,从而增强了对肿瘤的免疫反应,进一步抑制了肿瘤转移。这些特点使我们的策略非常适用于各种转移性癌症。
期刊介绍:
ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.