Two-dimensional (2D) materials with inherently low thermal conductivity offer significant advantages for thermal management due to constrained phonon transport. The introduction of rotational degrees of freedom in layered 2D materials to form Moiré superlattices enables precise modulation of material properties, including electronic band gaps and phonon scattering mechanisms. While simulations have demonstrated that twisted multilayer Moiré structures can significantly reduce thermal conductivity through enhanced scattering and localized phonon modes, experimental progress has been limited due to challenges in synthesizing multilayer superlattices. In this study, we report the in situ synthesis of SnSe2 nanosheets with twisted multilayer Moiré structures using a scalable chemical vapor deposition method. These superlattices, exhibiting multiple Moiré periods, achieve a significant reduction in thermal conductivity compared to regular multilayer structures, driven by enhanced phonon scattering, lattice mismatch, and localized phonon modes. This work establishes multilayer Moiré superlattices as a promising and scalable platform for engineering low thermal conductivity 2D materials for advanced energy and electronic applications.
{"title":"Reduced Thermal Conductivity in SnSe2 Moiré Superlattices","authors":"Yutong Ran, Chen Meng, Yunpeng Ma, Qian Li, Hongwei Zhu","doi":"10.1021/acsnano.5c00295","DOIUrl":"https://doi.org/10.1021/acsnano.5c00295","url":null,"abstract":"Two-dimensional (2D) materials with inherently low thermal conductivity offer significant advantages for thermal management due to constrained phonon transport. The introduction of rotational degrees of freedom in layered 2D materials to form Moiré superlattices enables precise modulation of material properties, including electronic band gaps and phonon scattering mechanisms. While simulations have demonstrated that twisted multilayer Moiré structures can significantly reduce thermal conductivity through enhanced scattering and localized phonon modes, experimental progress has been limited due to challenges in synthesizing multilayer superlattices. In this study, we report the in situ synthesis of SnSe<sub>2</sub> nanosheets with twisted multilayer Moiré structures using a scalable chemical vapor deposition method. These superlattices, exhibiting multiple Moiré periods, achieve a significant reduction in thermal conductivity compared to regular multilayer structures, driven by enhanced phonon scattering, lattice mismatch, and localized phonon modes. This work establishes multilayer Moiré superlattices as a promising and scalable platform for engineering low thermal conductivity 2D materials for advanced energy and electronic applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shengmin Zhang, Liang Wang, Zhichao Feng, Zhiqi Wang, Yingxue Wang, Benjie Wei, Hong Liu, Weiwei Zhao, Jianhua Li
MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant to fields such as energy storage, environmental science, and biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications in tissue regeneration is still in its early stages, with a notable absence of comprehensive reviews. This review begins with a detailed description of the intrinsic properties of MXene, followed by a discussion of the various nanostructures that MXene can form, spanning from 0 to 3 dimensions. The focus then shifts to the applications of MXene-based biomaterials in tissue engineering, particularly in immunomodulation, wound healing, bone regeneration, and nerve regeneration. MXene’s physicochemical properties, including conductivity, photothermal characteristics, and antibacterial properties, facilitate interactions with different cell types, influencing biological processes. These interactions highlight its potential in modulating cellular functions essential for tissue regeneration. Although the research on MXene in tissue regeneration is still developing, its versatile structural and physicochemical attributes suggest its potential role in advancing regenerative medicine.
{"title":"Engineered MXene Biomaterials for Regenerative Medicine","authors":"Shengmin Zhang, Liang Wang, Zhichao Feng, Zhiqi Wang, Yingxue Wang, Benjie Wei, Hong Liu, Weiwei Zhao, Jianhua Li","doi":"10.1021/acsnano.4c16136","DOIUrl":"https://doi.org/10.1021/acsnano.4c16136","url":null,"abstract":"MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant to fields such as energy storage, environmental science, and biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications in tissue regeneration is still in its early stages, with a notable absence of comprehensive reviews. This review begins with a detailed description of the intrinsic properties of MXene, followed by a discussion of the various nanostructures that MXene can form, spanning from 0 to 3 dimensions. The focus then shifts to the applications of MXene-based biomaterials in tissue engineering, particularly in immunomodulation, wound healing, bone regeneration, and nerve regeneration. MXene’s physicochemical properties, including conductivity, photothermal characteristics, and antibacterial properties, facilitate interactions with different cell types, influencing biological processes. These interactions highlight its potential in modulating cellular functions essential for tissue regeneration. Although the research on MXene in tissue regeneration is still developing, its versatile structural and physicochemical attributes suggest its potential role in advancing regenerative medicine.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"16 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development of acoustic nanocavities with resonant frequencies in the gigahertz to terahertz range has enabled advancements in quantum information processing, acoustic sensing, and advanced optoacoustic devices. Here, we demonstrate the generation and strong coupling of coherent acoustic phonons within metal-van der Waals (vdWs) heterostructure nanocavities, constructed from semiconductor MoS2 and insulating h-BN thin films, integrated with chemically synthesized Au nanosheets. Both heterostructures exhibit extended coherent phonon spectra, as observed through ultrafast femtosecond pump–probe spectroscopy. The inhomogeneous broadening features of these spectra are accurately reproduced using finite element method simulations and continuum mechanics calculations. A detailed analysis of the phonon coupling mechanism using a spring model reveals distinct coupling strengths of 78 and 55 GHz for the MoS2/Au and h-BN/Au nanocavities, respectively. Notably, the presence of a thin polymer (PVP) spacer layer at the metal-vdWs interface significantly influences the interfacial coupling strength and phonon lifetime. These findings provide insights into phonon coupling optimization in metal-vdWs nanocavities, contributing to the design of high-performance phononic devices.
{"title":"Coherent Acoustic Phonon Dynamics and Coupling in Metal-van der Waals Heterostructure Nanocavities","authors":"Jiaqi Zhang, Kuai Yu, Guo Ping Wang","doi":"10.1021/acsnano.4c16912","DOIUrl":"https://doi.org/10.1021/acsnano.4c16912","url":null,"abstract":"The development of acoustic nanocavities with resonant frequencies in the gigahertz to terahertz range has enabled advancements in quantum information processing, acoustic sensing, and advanced optoacoustic devices. Here, we demonstrate the generation and strong coupling of coherent acoustic phonons within metal-van der Waals (vdWs) heterostructure nanocavities, constructed from semiconductor MoS<sub>2</sub> and insulating h-BN thin films, integrated with chemically synthesized Au nanosheets. Both heterostructures exhibit extended coherent phonon spectra, as observed through ultrafast femtosecond pump–probe spectroscopy. The inhomogeneous broadening features of these spectra are accurately reproduced using finite element method simulations and continuum mechanics calculations. A detailed analysis of the phonon coupling mechanism using a spring model reveals distinct coupling strengths of 78 and 55 GHz for the MoS<sub>2</sub>/Au and h-BN/Au nanocavities, respectively. Notably, the presence of a thin polymer (PVP) spacer layer at the metal-vdWs interface significantly influences the interfacial coupling strength and phonon lifetime. These findings provide insights into phonon coupling optimization in metal-vdWs nanocavities, contributing to the design of high-performance phononic devices.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"2 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A closed-loop pathway of “efficient actuation-synchronous sensing-multimodal feedback” is crucial for actuators to adapt to complex scenarios and human–environment interactions. Strategies to reconcile mechanics-guaranteed adaptive actuation with multimodal responses and perceptivity remain challenging. Through a continuous electrospinning strategy to construct a reinforced fiber-interlocked interface, a bilayer fiber membrane (TCTR) actuator composed of highly aligned fiber and hierarchical structures is developed to obtain efficient photothermal performance (22.9 °C min–1), excellent mechanical toughness (17.9 MJ m–3), and intuitive color changes (dark purple red to bright pale yellow with lightness variation of 68). This humidity-dominated and photothermal-assisted-responsive actuator demonstrates superior actuation response (0.67 cm–1 s–1) and bending curvature (7.37 cm–1) with electro-visual cooperative perceptivity. Integrated with the actuation-triggered triboelectric self-powered sensing and synchronous thermochromic effect, the TCTR actuator can be differentially programmed to perceive material types and object temperature (with a sensitivity of 99.5%), and visualize writing paths. By optimizing fiber alignment and assembly pattern, TCTR demonstrates utility as filter material, smart mask, and electronic textile, which can sense and visualize air contamination degrees, environmental temperature, and respiratory status, as well as achieve thermal management/alarming. This work proposes materials with mechano-electrical-optical cooperation and inspires a facile strategy for human–environment interactive actuators with multiscenario adaptivity.
{"title":"Adaptive All-Fiber Actuator for Human–Environment Interaction","authors":"Yufan Zhang, Tao Zhang, Yunjie Gu, Minghui Fan, Yue Zhang, Shuang Wang, Yong Xia, Xinran Zhou, Jiaqing Xiong","doi":"10.1021/acsnano.4c17638","DOIUrl":"https://doi.org/10.1021/acsnano.4c17638","url":null,"abstract":"A closed-loop pathway of “efficient actuation-synchronous sensing-multimodal feedback” is crucial for actuators to adapt to complex scenarios and human–environment interactions. Strategies to reconcile mechanics-guaranteed adaptive actuation with multimodal responses and perceptivity remain challenging. Through a continuous electrospinning strategy to construct a reinforced fiber-interlocked interface, a bilayer fiber membrane (TCTR) actuator composed of highly aligned fiber and hierarchical structures is developed to obtain efficient photothermal performance (22.9 °C min<sup>–1</sup>), excellent mechanical toughness (17.9 MJ m<sup>–3</sup>), and intuitive color changes (dark purple red to bright pale yellow with lightness variation of 68). This humidity-dominated and photothermal-assisted-responsive actuator demonstrates superior actuation response (0.67 cm<sup>–1</sup> s<sup>–1</sup>) and bending curvature (7.37 cm<sup>–1</sup>) with electro-visual cooperative perceptivity. Integrated with the actuation-triggered triboelectric self-powered sensing and synchronous thermochromic effect, the TCTR actuator can be differentially programmed to perceive material types and object temperature (with a sensitivity of 99.5%), and visualize writing paths. By optimizing fiber alignment and assembly pattern, TCTR demonstrates utility as filter material, smart mask, and electronic textile, which can sense and visualize air contamination degrees, environmental temperature, and respiratory status, as well as achieve thermal management/alarming. This work proposes materials with mechano-electrical-optical cooperation and inspires a facile strategy for human–environment interactive actuators with multiscenario adaptivity.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"30 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High-power sodium-ion batteries are essential for grid energy storage; however, they are generally limited by Na+ transport. Herein, we tailor a highly matched heterostructure (MgTi3O7@Na2Ti3O7) via a facile in situ synthesis method. The similar crystal structures of Na2Ti3O7 and MgTi3O7 creat continuous Na+ diffusion channels at the heterointerface, and the interactions at the interface creat a built-in interface electric field with a direction from MgTi3O7 to Na2Ti3O7. As a result, the particular heterointerface enable rapid Na+ diffusion in the MgTi3O7@Na2Ti3O7 electrode. The heterostructure engineering regulate the electrochemical reaction mechanism, leading to the solid solution reaction in the MgTi3O7@Na2Ti3O7 electrode, facilitating rapid Na+ transport. Therefore, the MgTi3O7@Na2Ti3O7 electrode exhibits an excellent rate capability (123 mAh/g at 20 C) and cycling performance. This work highlights the importance of a heterointerface with continuous channels in overcoming Na+ transport limitations in electrodes and could serves as a guide for designing a heterointerface for high-power sodium-ion batteries.
{"title":"Heterointerface with Continuous Channels Enables Fast Na+ Transport in Layered Na2Ti3O7","authors":"Jun Dong, Zilun Chen, Jiajing Wang, Yalong Jiang, Jian Ao, Ruxing Wang, Jianxin Pan, Qiulong Wei, Xiaoxing Zhang","doi":"10.1021/acsnano.4c18215","DOIUrl":"https://doi.org/10.1021/acsnano.4c18215","url":null,"abstract":"High-power sodium-ion batteries are essential for grid energy storage; however, they are generally limited by Na<sup>+</sup> transport. Herein, we tailor a highly matched heterostructure (MgTi<sub>3</sub>O<sub>7</sub>@Na<sub>2</sub>Ti<sub>3</sub>O<sub>7</sub>) via a facile in situ synthesis method. The similar crystal structures of Na<sub>2</sub>Ti<sub>3</sub>O<sub>7</sub> and MgTi<sub>3</sub>O<sub>7</sub> creat continuous Na<sup>+</sup> diffusion channels at the heterointerface, and the interactions at the interface creat a built-in interface electric field with a direction from MgTi<sub>3</sub>O<sub>7</sub> to Na<sub>2</sub>Ti<sub>3</sub>O<sub>7</sub>. As a result, the particular heterointerface enable rapid Na<sup>+</sup> diffusion in the MgTi<sub>3</sub>O<sub>7</sub>@Na<sub>2</sub>Ti<sub>3</sub>O<sub>7</sub> electrode. The heterostructure engineering regulate the electrochemical reaction mechanism, leading to the solid solution reaction in the MgTi<sub>3</sub>O<sub>7</sub>@Na<sub>2</sub>Ti<sub>3</sub>O<sub>7</sub> electrode, facilitating rapid Na<sup>+</sup> transport. Therefore, the MgTi<sub>3</sub>O<sub>7</sub>@Na<sub>2</sub>Ti<sub>3</sub>O<sub>7</sub> electrode exhibits an excellent rate capability (123 mAh/g at 20 C) and cycling performance. This work highlights the importance of a heterointerface with continuous channels in overcoming Na<sup>+</sup> transport limitations in electrodes and could serves as a guide for designing a heterointerface for high-power sodium-ion batteries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"84 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sixing Yin, Rongyao Li, Hongfei Wu, Xirui Huang, Lu Liu, Jialong Li, Xiaoyu Li, Jie Zhang, Yuzhu Ma, Dongyuan Zhao, Kun Lan
Metal sulfide materials, endowed with ordered mesoporosity, offer ample opportunities in a variety of renewable energy applications due to the integration of intrinsic functional properties and enhanced reaction kinetics. Unfortunately, ordered mesoporous metal sulfides have rarely been reported due to immense synthetic difficulties by conventional self-assembly approaches. Herein, we explore a compatible coordinated ionic self-assembly strategy for the facile synthesis of highly ordered mesoporous Pt2Sn2S6 networks with templated mesopores at 4.2 nm in hexagonal mesophase (space group p6mm) and highly accessible surface area. The self-assembly mechanism is further investigated, revealing the role of the cationic surfactant and anionic sulfur pair in balancing suitable interaction and the utilized ammonia and ligand to retard fast precipitation of metal and sulfur source for effective assembly. Owing to the combination of ordered porosity and intrinsic functionality, the mesoporous Pt2Sn2S6 after crystallization exhibits excellent activity (overpotential of 13 mV, Tafel slope of 34 mV dec–1) and long-term durability over 100 h for electrochemical hydrogen evolution reaction (HER) in alkaline solution. Our study provides a toolbox for the rational synthesis of functional mesoporous compositions as advanced model platforms for future versatile technologies.
{"title":"Coordinated Ionic Self-Assembly of Highly Ordered Mesoporous Pt2Sn2S6 Networks for Boosted Hydrogen Evolution","authors":"Sixing Yin, Rongyao Li, Hongfei Wu, Xirui Huang, Lu Liu, Jialong Li, Xiaoyu Li, Jie Zhang, Yuzhu Ma, Dongyuan Zhao, Kun Lan","doi":"10.1021/acsnano.4c17914","DOIUrl":"https://doi.org/10.1021/acsnano.4c17914","url":null,"abstract":"Metal sulfide materials, endowed with ordered mesoporosity, offer ample opportunities in a variety of renewable energy applications due to the integration of intrinsic functional properties and enhanced reaction kinetics. Unfortunately, ordered mesoporous metal sulfides have rarely been reported due to immense synthetic difficulties by conventional self-assembly approaches. Herein, we explore a compatible coordinated ionic self-assembly strategy for the facile synthesis of highly ordered mesoporous Pt<sub>2</sub>Sn<sub>2</sub>S<sub>6</sub> networks with templated mesopores at 4.2 nm in hexagonal mesophase (space group <i>p6mm</i>) and highly accessible surface area. The self-assembly mechanism is further investigated, revealing the role of the cationic surfactant and anionic sulfur pair in balancing suitable interaction and the utilized ammonia and ligand to retard fast precipitation of metal and sulfur source for effective assembly. Owing to the combination of ordered porosity and intrinsic functionality, the mesoporous Pt<sub>2</sub>Sn<sub>2</sub>S<sub>6</sub> after crystallization exhibits excellent activity (overpotential of 13 mV, Tafel slope of 34 mV dec<sup>–1</sup>) and long-term durability over 100 h for electrochemical hydrogen evolution reaction (HER) in alkaline solution. Our study provides a toolbox for the rational synthesis of functional mesoporous compositions as advanced model platforms for future versatile technologies.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"35 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the clinical translation of siRNA-based therapies is significantly hampered by the formidable blood-brain barrier (BBB), which restricts drug penetration into the central nervous system. To address this challenge, we have developed an innovative long-circulating near-infrared II (NIR-II) nanoparticle platform YWFC NPs, which is meticulously engineered to enhance BBB transcytosis and enable efficient delivery of siRNA targeting NLRP3 (siNLRP3@YWFC NPs) in preclinical models of ischemic stroke. Furthermore, we integrated advanced deep learning neural network algorithms to optimize in vivo NIR-II imaging of the cerebral infarct penumbra, achieving an improved signal-to-background ratio at 72 h poststroke. In vivo studies employing middle cerebral artery occlusion (MCAO) mouse models demonstrated that image-guided therapy with siNLRP3@YWFC NPs, guided by prolonged NIR-II imaging, resulted in significant therapeutic benefits.
{"title":"Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke","authors":"Kai Yu, Lidan Fu, Yu Chao, Xiaodong Zeng, Yonggang Zhang, Yuanyuan Chen, Jialu Gao, Binchun Lu, Hua Zhu, Lijuan Gu, Xiaoxing Xiong, Zhenhua Hu, Xuechuan Hong, Yuling Xiao","doi":"10.1021/acsnano.4c18035","DOIUrl":"https://doi.org/10.1021/acsnano.4c18035","url":null,"abstract":"Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the clinical translation of siRNA-based therapies is significantly hampered by the formidable blood-brain barrier (BBB), which restricts drug penetration into the central nervous system. To address this challenge, we have developed an innovative long-circulating near-infrared II (NIR-II) nanoparticle platform YWFC NPs, which is meticulously engineered to enhance BBB transcytosis and enable efficient delivery of siRNA targeting NLRP3 (siNLRP3@YWFC NPs) in preclinical models of ischemic stroke. Furthermore, we integrated advanced deep learning neural network algorithms to optimize <i>in vivo</i> NIR-II imaging of the cerebral infarct penumbra, achieving an improved signal-to-background ratio at 72 h poststroke. <i>In vivo</i> studies employing middle cerebral artery occlusion (MCAO) mouse models demonstrated that image-guided therapy with siNLRP3@YWFC NPs, guided by prolonged NIR-II imaging, resulted in significant therapeutic benefits.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"19 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An important question in polariton chemistry is whether reacting molecules are in thermal equilibrium with their surroundings. If not, can experimental changes observed in reaction rates of molecules in a cavity (even without optical pumping) be attributed to a higher/lower temperature inside the cavity? In this work, we address this question by computing the temperature differences between reacting molecules inside a cavity and the air outside. We found this temperature difference to be negligible for most reactions. On the other hand, for phase transitions inside cavities, as the temperature of the material is actively maintained by a heating/cooling source in experiments, we show that cavities can modify observed transition temperatures when mirrors and cavity windows are ideal (nonabsorbing); however, this modification vanishes when real mirrors and windows are used. This conclusion relies on having a low contact resistance between mirrors and molecules. Finally, we find substantial differences in blackbody spectral energy density between free space and infrared cavities, which reveal resonance effects and could potentially play a role in explaining changes in the chemical reactivity in the dark.
{"title":"Blackbody Radiation and Thermal Effects on Chemical Reactions and Phase Transitions in Cavities","authors":"Sindhana Pannir-Sivajothi, Joel Yuen-Zhou","doi":"10.1021/acsnano.4c14590","DOIUrl":"https://doi.org/10.1021/acsnano.4c14590","url":null,"abstract":"An important question in polariton chemistry is whether reacting molecules are in thermal equilibrium with their surroundings. If not, can experimental changes observed in reaction rates of molecules in a cavity (even without optical pumping) be attributed to a higher/lower temperature inside the cavity? In this work, we address this question by computing the temperature differences between reacting molecules inside a cavity and the air outside. We found this temperature difference to be negligible for most reactions. On the other hand, for phase transitions inside cavities, as the temperature of the material is actively maintained by a heating/cooling source in experiments, we show that cavities can modify observed transition temperatures when mirrors and cavity windows are ideal (nonabsorbing); however, this modification vanishes when real mirrors and windows are used. This conclusion relies on having a low contact resistance between mirrors and molecules. Finally, we find substantial differences in blackbody spectral energy density between free space and infrared cavities, which reveal resonance effects and could potentially play a role in explaining changes in the chemical reactivity in the dark.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"53 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caiting Meng, Shuaijun Li, Yana Ma, Hongwen Yu, Jiaqi Song, Junchao Zhi, Bin Zhu, Liang Shao, Xinling Liu, Lulu Yang, Mingzhen Zhang, Ye Zhang, Guanying Li
We introduce ruthenosomes, a fusion of liposomal and reactive oxygen species (ROS)–generating properties meticulously engineered as potent ferroptosis inducers (FINs), marking a significant advancement in metallodrug design for cancer therapy. Formed through the self-assembly of oleate-conjugated ruthenium complexes, these ruthenosomes exhibit exceptional cellular uptake, selectively accumulating in mitochondria and causing substantial disruption. This targeted mitochondrial damage significantly elevates ROS levels, triggering autophagy and selectively activating ferritinophagy. Together, these processes sensitize cancer cells to ferroptosis. In vivo, ruthenosomes effectively suppress colorectal tumor growth, underscoring their therapeutic potential. Our study pioneers a design strategy that transforms ruthenium complexes into liposome-like structures capable of inducing ferroptosis independent of light activation. By leveraging ruthenosomes as multifunctional nanocarriers, this research offers a versatile and powerful platform for ROS-mediated, ferroptosis-driven cancer cell eradication.
{"title":"Assembling Ruthenium Complexes to Form Ruthenosome Unleashing Ferritinophagy-Mediated Tumor Suppression","authors":"Caiting Meng, Shuaijun Li, Yana Ma, Hongwen Yu, Jiaqi Song, Junchao Zhi, Bin Zhu, Liang Shao, Xinling Liu, Lulu Yang, Mingzhen Zhang, Ye Zhang, Guanying Li","doi":"10.1021/acsnano.4c17344","DOIUrl":"https://doi.org/10.1021/acsnano.4c17344","url":null,"abstract":"We introduce ruthenosomes, a fusion of liposomal and reactive oxygen species (ROS)–generating properties meticulously engineered as potent ferroptosis inducers (FINs), marking a significant advancement in metallodrug design for cancer therapy. Formed through the self-assembly of oleate-conjugated ruthenium complexes, these ruthenosomes exhibit exceptional cellular uptake, selectively accumulating in mitochondria and causing substantial disruption. This targeted mitochondrial damage significantly elevates ROS levels, triggering autophagy and selectively activating ferritinophagy. Together, these processes sensitize cancer cells to ferroptosis. In vivo, ruthenosomes effectively suppress colorectal tumor growth, underscoring their therapeutic potential. Our study pioneers a design strategy that transforms ruthenium complexes into liposome-like structures capable of inducing ferroptosis independent of light activation. By leveraging ruthenosomes as multifunctional nanocarriers, this research offers a versatile and powerful platform for ROS-mediated, ferroptosis-driven cancer cell eradication.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donato Civita, Matthew Timm, Jutta Schwarz, Stefan Hecht, Leonhard Grill
The breaking of an interatomic bond is at the heart of chemistry yet remains a challenge to be investigated. Molecules on metal surfaces exhibit defined positions and orientations and can be characterized by scanning tunneling microscopy that moreover is able to trigger bond breaking. Until now, the bond dissociation dynamics has been studied in small molecules but not in large ones with various degrees of freedom. Here, we dissociate bromine atoms from single dibromo-terfluorene molecules on Ag(111), identifying not only the displacement but also the rotation of each fragment. It turns out that the molecular excitation that causes dissociation is not locally confined. Instead, it can propagate through the molecule, and the dynamics of the resulting fragments is uncorrelated. The fragment binds to the nearest silver atom after dissociation and dissipates its energy in rotational motion. Our findings could be useful for the precise engineering of chemical reactions with prearranged precursor molecules.
{"title":"Bond Dissociation Dynamics of Single Molecules on a Metal Surface","authors":"Donato Civita, Matthew Timm, Jutta Schwarz, Stefan Hecht, Leonhard Grill","doi":"10.1021/acsnano.4c17652","DOIUrl":"https://doi.org/10.1021/acsnano.4c17652","url":null,"abstract":"The breaking of an interatomic bond is at the heart of chemistry yet remains a challenge to be investigated. Molecules on metal surfaces exhibit defined positions and orientations and can be characterized by scanning tunneling microscopy that moreover is able to trigger bond breaking. Until now, the bond dissociation dynamics has been studied in small molecules but not in large ones with various degrees of freedom. Here, we dissociate bromine atoms from single dibromo-terfluorene molecules on Ag(111), identifying not only the displacement but also the rotation of each fragment. It turns out that the molecular excitation that causes dissociation is not locally confined. Instead, it can propagate through the molecule, and the dynamics of the resulting fragments is uncorrelated. The fragment binds to the nearest silver atom after dissociation and dissipates its energy in rotational motion. Our findings could be useful for the precise engineering of chemical reactions with prearranged precursor molecules.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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