Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients

IF 2.5 3区生物学 Q3 MICROBIOLOGY Anaerobe Pub Date : 2024-06-26 DOI:10.1016/j.anaerobe.2024.102880

Truong Nguyen Duy , Hoang Le Huy , Quyen Đao Thanh , Hoai Ngo Thi , Hanh Ngo Thi Minh , Manh Nguyen Dang , Song Le Huu , Trung Ngo Tat

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Abstract

Background

Colorectal cancer (CRC) is a significant global health concern, and understanding the role of specific bacterial infections in its development and progression is of increasing interest. This cross-sectional study investigated the associations between Bacteroides fragilis (B. fragilis) and Fusobacterium nucleatum (F. nucleatum) infections and Vietnamese CRC patients.

Methods

192 patients with either polyps or CRC at varying stages were recruited from May 2017 to December 2020. Real-time PCR assessed infection rates and bacterial loads in CRC tissues.

Results

B. fragilis infection was notably higher in CRC tissues (51.6 %) than polyps (9.4 %), with a fivefold higher relative load. Positive associations were found in stages II and III, indicating a fivefold increase in CRC progression risk. F. nucleatum infection rates were significantly higher in CRC tissues (55.2 %) than in polyps (10.5 %). In stage II, the infection rate exceeded that in adjacent tissues. The relative load of F. nucleatum was higher in stage III than in stages I and II. Positive F. nucleatum patients had a 3.2 times higher risk of CRC progression.

Conclusion

These findings suggest associations between loading of F. nucleatum or/and B. fragilis with the advanced stages of CRC.

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越南患者中脆弱拟杆菌和核酸镰刀菌感染与结直肠癌之间的关系

背景：结肠直肠癌（CRC）是全球关注的重大健康问题，了解特定细菌感染在其发生和发展中的作用越来越受到关注。这项横断面研究调查了脆弱拟杆菌（B. fragilis）和核酸镰刀菌（F. nucleatum）感染与越南 CRC 患者之间的关联。方法：2017 年 5 月至 2020 年 12 月期间，招募了 192 名不同阶段的息肉或 CRC 患者。实时 PCR 评估了 CRC 组织中的感染率和细菌量：CRC组织中B. fragilis感染率（51.6%）明显高于息肉（9.4%），相对载量高出5倍。在 II 期和 III 期发现了正相关，表明 CRC 进展风险增加了五倍。CRC 组织中的 F. nucleatum 感染率（55.2%）明显高于息肉（10.5%）。在二期，感染率超过了邻近组织。在 III 期，F. nucleatum 的相对载量高于 I 期和 II 期。核酸桿菌陽性患者的 CRC 發病風險高出 3.2 倍：这些研究结果表明，F. nucleatum或/和B. fragilis的载量与CRC的晚期阶段有关。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.