Contact sensitization to fragrance mix I and fragrance mix II among European dermatitis patients: A systematic review

IF 4.8 1区医学 Q2 ALLERGY Contact Dermatitis Pub Date : 2024-06-30 DOI:10.1111/cod.14618

Sofia Botvid, Niels H. Bennike, Anne Birgitte Simonsen, Jeanne Duus Johansen, Wolfgang Uter

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Abstract

Background

Fragrance substances are a frequent cause of contact allergy worldwide. Fragrance exposure varies by sex, age and possibly country, influenced by cosmetic availability, environmental conditions and cultural practices.

Objectives

To systematically review and gather prevalence of sensitization to fragrance mix I (FM I) and fragrance mix II (FM II) in consecutively patch tested European dermatitis patients.

Method

A total of 4134 publications on patch test results of European dermatitis patients, published from 1981 to 2022, were systematically reviewed according to a previously registered and published PROSPERO protocol.

Results

Eighty-four eligible original articles were analysed. Overall prevalence of sensitization to fragrance mix I (FM I) was 6.81% (95% CI: 6.37–7.28), and FM II was 3.64% (95% CI: 3.3–4.01). Sensitization to FM I was most prevalent in Central and Eastern Europe and to FM II in Western Europe. No clear time trends were observed. Among paediatric dermatitis patients, sensitization prevalence for FM I and FM II was 4.09% (95% CI: 3.37–4.96) and 2.17% (95% CI: 1.53–3.07).

Conclusion

The frequency of positive patch test results for both FMI and FMII remains high. Sensitization is also prevalent among children. Enhanced regulation and labelling of cosmetic products play a vital role in averting exposure and sensitization to fragrance allergens.

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欧洲皮炎患者对混合香料 I 和混合香料 II 的接触过敏：系统综述。

背景：香料物质是全球接触性过敏的常见原因。受化妆品供应、环境条件和文化习俗的影响，不同性别、年龄以及可能不同国家的人接触香料的情况各不相同：系统回顾并收集欧洲皮炎患者在连续贴片测试中对混合香料 I（FM I）和混合香料 II（FM II）过敏的流行率：方法：根据先前注册和发布的 PROSPERO 协议，系统审查了 1981 年至 2022 年间发表的有关欧洲皮炎患者贴片测试结果的 4134 篇文献：结果：对 84 篇符合条件的原创文章进行了分析。对混合香料 I（FM I）过敏的总发病率为 6.81%（95% CI：6.37-7.28），对混合香料 II 过敏的总发病率为 3.64%（95% CI：3.3-4.01）。中欧和东欧对 FM I 最敏感，西欧对 FM II 最敏感。没有观察到明显的时间趋势。在儿童皮炎患者中，FM I 和 FM II 的致敏率分别为 4.09% (95% CI: 3.37-4.96) 和 2.17% (95% CI: 1.53-3.07)：FMI 和 FMII 的贴片测试结果呈阳性的频率仍然很高。致敏现象在儿童中也很普遍。加强化妆品的监管和标签对于避免接触香料过敏原和对其过敏起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".