Contact Dermatitis最新文献

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The association between wet work and hand eczema in the Dutch general population: Application of a job exposure matrix to the lifelines cohort study. 荷兰普通人群中潮湿工作与手部湿疹之间的关系：将工作暴露矩阵应用于生命线队列研究。

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-24 DOI: 10.1111/cod.14687

Marjolein J Brands, Laura Loman, Tamara T Lund, Esben M Flachs, Ute Bültmann, Marie L A Schuttelaar

Background: Studies on wet work and hand eczema (HE) frequently rely solely on self-reports regarding wet work.

Objectives: To assess the association between wet work and moderate-to-very-severe HE, within the Dutch general population, by using a (sex-specific) job exposure matrix (JEM).

Methods: Within the Lifelines Cohort Study, participants with self-reported moderate-to-very-severe HE at worst in the past year were linked to data from the Danish (sex-specific) wet work JEM, a tool that links occupations with wet work indices (including duration and probability of glove use, wet hands and total wet work for at least 2 and 4 h/working day).

Results: In total, 56 978 (41.9%) participants were included. The multivariate binary logistic regression analyses showed significant associations between all facets of wet work and moderate-to-very-severe HE. When using the sex-specific JEM, significant associations were found in females, but not in males.

Conclusions: This study is the first to use a wet work-specific JEM in a general population sample, and found positive associations between wet work and HE. The sex-specific findings should be interpreted with caution, due to limitations inherent in using a JEM, and should be further explored with observational studies, with a focus on duration, frequency, and exposure type.

背景：有关潮湿工作和手部湿疹（HE）的研究通常仅依赖于有关潮湿工作的自我报告：方法：在生命线队列研究（Lifelines Cohort Study）中，对自我报告患有中度至重度手部湿疹的参与者进行调查：方法：在生命线队列研究（Lifelines Cohort Study）中，将自述在过去一年中患有最严重中度至重度高血压的参与者与丹麦（性别特异性）湿式工作暴露矩阵（JEM）中的数据联系起来，该矩阵是一种将职业与湿式工作指数（包括使用手套的持续时间和概率、湿手以及至少2小时和4小时/工作日的湿式工作总量）联系起来的工具：共有 56 978 人（41.9%）被纳入调查范围。多变量二元逻辑回归分析表明，湿手工作的所有方面与中度至重度高血压之间存在显著关联。在使用性别特异性 JEM 时，发现女性与中度至重度高血压有显著关联，而男性则没有：本研究首次在普通人群样本中使用湿作业特异性 JEM，发现湿作业与 HE 之间存在正相关。由于使用 JEM 所固有的局限性，对性别特异性研究结果的解释应谨慎，并应通过观察性研究进行进一步探讨，重点关注持续时间、频率和暴露类型。

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引用次数: 0

Severe allergic contact dermatitis caused by methoxypropylamino cyclohexenylidene ethoxyethylcyanoacetate. 甲氧基丙基氨基环己烯亚乙氧基乙基氰基乙酸酯引起的严重过敏性接触性皮炎。

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-21 DOI: 10.1111/cod.14700

Audrey Loretan, Federica Bertone, Sebastien Menzinger, Pierre Piletta, Yassaman Alipour Tehrany

引用次数: 0

The value of patch testing with plants “as is” in diagnosing plant sensitization 植物 "原样 "斑贴试验在诊断植物过敏症中的价值

IF 5.5 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-19 DOI: 10.1111/cod.14680

Evy Paulsen, Charlotte G. Mortz

BackgroundThe number of commercially available plant allergens/extracts is limited and therefore patch testing with fresh/dried plant material may be a necessary supplement in diagnosing plant allergy.ObjectivesTo evaluate the usefulness of patch testing with plants “as is” compared to patch testing with commercial and in‐house produced plant test materials and to report on species eliciting positive patch test reactions.Patients/Materials/MethodsConsecutive eczema patients, who were patch tested between January 2019 and December 2023 and who had at least one positive reaction to a plant allergen and/or extract and/or plant “as is” were included in the study.ResultsA total 57 out of 1893 patients tested (3%) were sensitised to plants. Compositae plants were the most frequent sensitizers, followed by tomato, tulipalin A, falcarinol, and Philodendron plants. In 12 patients (21%), the diagnosis was based on patch testing with fresh plants only. Occupational sensitization occurred in 32%. Other sensitizers included Hydrangea, Pelargonium zonale, and Monstera.ConclusionsA large minority of plant‐sensitised patients would have been undiagnosed without patch testing with plants “as is.” Most of the culprit plants were known sensitizers, but not commercially available, and these and new species taken into cultivation makes patch testing with fresh plants unavoidable and worthwhile.

背景市售植物过敏原/提取物的数量有限，因此使用新鲜/干燥植物材料进行斑贴试验可能是诊断植物过敏的必要补充。目的评估使用植物 "原样 "进行斑贴试验与使用市售和自制植物试验材料进行斑贴试验的效用，并报告引起斑贴试验阳性反应的物种。患者/材料/方法在2019年1月至2023年12月期间接受贴敷测试的连续湿疹患者，以及对植物过敏原和/或提取物和/或植物 "原样 "至少有一次阳性反应的患者均被纳入研究范围。结果在1893名接受测试的患者中，共有57人（3%）对植物过敏。最常见的致敏植物是锦葵科植物，其次是番茄、郁金香苷 A、镰刀菌素和蕨类植物。有 12 名患者（21%）的诊断仅基于新鲜植物的斑贴试验。职业性致敏占 32%。结论：如果不对植物进行 "原样 "斑贴试验，少数植物致敏患者可能无法确诊。大多数致敏植物都是已知的致敏物质，但并不是市面上可以买到的，这些植物和新栽培的物种使得使用新鲜植物进行斑贴试验变得不可避免且值得。

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引用次数: 0

Acute generalised exanthematous pustulosis induced by betamethasone sodium phosphate: A case report. 倍他米松磷酸钠诱发的急性全身泛发性脓疱病：病例报告。

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-19 DOI: 10.1111/cod.14694

Ayaki Matsumoto, Eriko Hayashi, Chiharu Tateishi, Daisuke Tsuruta

引用次数: 0

Extensive allergic contact dermatitis to dexpanthenol with distant facial and symmetrical intertriginous involvement: An unusual clinical presentation 广泛的右泛醇过敏性接触性皮炎，面部和三叉神经间对称性受累：不寻常的临床表现

IF 5.5 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-17 DOI: 10.1111/cod.14693

Elisabeth Victoria Goessinger, Tamara Merkel, Sibylla Chantraine, Karin Hartmann

引用次数: 0

Biomonitoring of hand and forearm transepidermal water loss and skin PH among nursing apprentices 对护理学徒的手部和前臂经表皮失水及皮肤 PH 值进行生物监测

IF 5.5 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-13 DOI: 10.1111/cod.14690

Željka Babić, Franka Šakić, Jelena Macan

BackgroundMeasurements of transepidermal water loss (TEWL) and stratum corneum (SC) pH can help indicate work‐related skin barrier damage, but sensitivity to confounding personal and ambient factors limits their potential as biomonitoring tools.ObjectivesTo evaluate the difference between hand and forearm skin barrier conditions as a tool for early recognition of workers with occupational contact dermatitis.Participants and MethodsThe participants were nursing apprentices (N = 238, median age 19 years) from Zagreb, Croatia. They filled out a questionnaire based on the Nordic Occupational Skin Questionnaire, underwent a clinical examination of skin on the hands, and were evaluated for their TEWL and SC pH on the dorsum of the hand and volar part of the forearm.ResultsWe found that the difference between hand and forearm TEWL values (ΔTEWL) greater than 7 g/m2/h, or >50%, or the difference in SC ΔpH >0.50, predicted visible skin changes found on clinical examination. However, only the association with ΔpH >0.50 retained statistical significance when controlled for sex, age, ambient temperature, and relative humidity in a multiple regression model.ConclusionsThe difference between hand and forearm SC pH values is suggested as a reliable biomonitoring tool in recognition of damaged skin barrier conditions in occupational settings.

背景经表皮失水（TEWL）和角质层（SC）pH值的测量有助于显示与工作相关的皮肤屏障损伤，但对个人和环境因素的敏感性限制了其作为生物监测工具的潜力。参与者和方法参与者是来自克罗地亚萨格勒布的护理学徒（人数=238，中位年龄为 19 岁）。结果我们发现，手部和前臂的 TEWL 值（ΔTEWL）差值大于 7 g/m2/h 或 50%，或 SC ΔpH 差值大于 0.50，均可预测临床检查中发现的明显皮肤变化。结论手部和前臂 SC pH 值之间的差异可作为一种可靠的生物监测工具，用于识别职业环境中受损的皮肤屏障状况。

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引用次数: 0

Atopic dermatitis and hand eczema in Danish adults: A nationwide population‐based study 丹麦成年人的特应性皮炎和手部湿疹：一项基于全国人口的研究

IF 5.5 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-12 DOI: 10.1111/cod.14691

Anna Schultz Vinge, Lone Skov, Jeanne Duus Johansen, Anna Sophie Quaade

BackgroundAtopic dermatitis (AD) and hand eczema often co‐occur, particularly among adults.ObjectivesTo examine the interplay between AD and hand eczema in the general population, by characterising prevalence, disease severity, contact sensitization, and comorbidities in individuals with one or both conditions.Materials and MethodsIn this cross‐sectional study, 100 000 randomly selected adults in the Danish general population received a questionnaire via a secure, digital mailbox linked to their civil registration number. Participants answered questions regarding eczema, disease severity, patch testing, and comorbidities.ResultsA total of 40 007 individuals responded to the question on a lifetime prevalence of AD, and the prevalence among adult Danes was 9.0%. Nearly one third of individuals with AD reported moderate to severe disease. AD was associated with contact sensitization and increased hand eczema prevalence. Individuals with both AD and hand eczema reported worse disease severity. Furthermore, having both conditions was associated with an increased risk of psychiatric comorbidities.ConclusionsThis study provided updated information about unselected adults with AD in Denmark. Individuals with both AD and hand eczema represent a vulnerable subgroup that physicians should be attentive to.

背景特应性皮炎（AD）和手部湿疹经常同时发生，尤其是在成年人中。目的通过描述患有一种或两种疾病的人的患病率、疾病严重程度、接触过敏性和合并症，研究普通人群中特应性皮炎和手部湿疹之间的相互作用。参与者回答了有关湿疹、疾病严重程度、斑贴测试和合并症的问题。结果共有 40 007 人回答了有关 AD 终生患病率的问题，丹麦成年人的患病率为 9.0%。近三分之一的 AD 患者报告患有中度至重度疾病。注意力缺失症与接触致敏和手部湿疹患病率增加有关。同时患有注意力缺失症和手部湿疹的患者的疾病严重程度更严重。此外，同时患有这两种疾病与精神疾病合并症的风险增加有关。同时患有注意力缺失症和手部湿疹的人是一个易受伤害的亚群体，医生应予以关注。

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引用次数: 0

Low sensitivity of a self‐report questionnaire for hand eczema in hairdressing apprentices 美发学徒手部湿疹自我报告问卷的灵敏度较低

IF 5.5 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-11 DOI: 10.1111/cod.14686

Jelena Kovačić, Zrinka Franić, Adrijana Bjelajac, Jelena Macan

BackgroundThe validity of the self‐report questionnaire for hand eczema (HE) among Croatian hairdressers was not investigated previously, leading to uncertainty in the prevalence estimated from self‐reported data.ObjectivesTo (1) investigate the validity of the self‐report questionnaire for HE in hairdressing apprentices and (2) examine the differences between apprentices who recognised their HE symptoms and those who did not.MethodsClinical examination for HE signs on hands and wrists was performed by the Osnabrueck Hand Eczema Severity Index for 408 apprentices at four visits covering the entire schooling period. Self‐report HE was based on the Nordic Occupational Skin Questionnaire.ResultsLow sensitivity (7%–37%) with high specificity (≥95%) was observed, with both measures improving from baseline to last visit. The severity of HE signs was the only factor associated with the correct identification of HE signs in analyses adjusted for previous HE signs, health‐related quality of life, and atopic dermatitis (adjusted odds ratios of 1.58 with 95% confidence interval [1.06–2.35] and 1.74[1.38–2.19] at second and third follow‐up visit, respectively).ConclusionsSelf‐report questionnaire for HE showed low sensitivity in hairdressing apprentices, especially at the beginning of training and in those with mild symptoms. Further validation studies following questionnaire modifications aimed at adolescent population are advised.

背景以前没有调查过克罗地亚美发师手部湿疹（HE）自我报告问卷的有效性，因此根据自我报告数据估算的患病率存在不确定性。方法采用奥斯纳布吕克手部湿疹严重程度指数（Osnabrueck Hand Eczema Severity Index）对 408 名学徒的手部和腕部湿疹症状进行临床检查，共进行了四次检查，涵盖整个在校学习期间。结果观察到的灵敏度较低（7%-37%），特异性较高（≥95%），从基线到最后一次就诊，这两项指标均有所改善。在对以往的 HE 征兆、健康相关生活质量和特应性皮炎进行调整后的分析中，HE 征兆的严重程度是唯一与正确识别 HE 征兆相关的因素（第二次和第三次随访时的调整赔率分别为 1.58，95% 置信区间为 [1.06-2.35] 和 1.74[1.38-2.19]）。建议在针对青少年群体修改问卷后，进一步开展验证研究。

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引用次数: 0

Incidence of allergic contact dermatitis in Finland 1998–2021: A nationwide registry‐based study 1998-2021 年芬兰过敏性接触性皮炎发病率：基于全国登记册的研究

IF 5.5 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-10 DOI: 10.1111/cod.14688

Ville Wikström, Suvi‐Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja

BackgroundAllergic contact dermatitis (ACD) may be chronic and can cause distress, disability, and absence from work. Nationwide epidemiological studies of ACD are sparse.ObjectivesTo use national registry data to study the incidence and aetiology of ACD in the working age population of Finland.MethodsPatient records from the years 1998–2021 were obtained from the Finnish Care Register for Health Care. Study subjects aged 18–65 years were selected on the basis of a diagnosis of ACD.ResultsTotal number of study subjects was 26 701. The incidence of ACD increased until 2016 after which it started to decrease. The increase was more marked in females and ACD was particularly common in women reporting reactions to cosmetics and other chemical products and in people of both sexes reacting to adhesives. The incidence ‘ACD of unspecific cause’ has decreased since 2016. The most commonly reported allergens were metals, followed by cosmetics. One fourth of subjects had ≥2 ACD diagnoses.ConclusionsThe incidence of ACD in working age subjects rose from 1998 to 2016, especially in females. However, the incidence has been decreasing since 2016. Our findings highlight the ongoing and even increasing burden of ACD among the working age population.

背景过敏性接触性皮炎（ACD）可能是一种慢性疾病，可导致痛苦、残疾和缺勤。方法从芬兰医疗保健登记册中获取1998-2021年的患者记录，根据诊断结果选择18-65岁的研究对象。研究对象年龄在18-65岁之间，根据ACD诊断结果进行筛选。ACD的发病率在2016年之前一直在上升，之后开始下降。女性的发病率上升更为明显，在报告对化妆品和其他化学产品产生反应的女性以及对粘合剂产生反应的男女人群中，ACD尤为常见。自 2016 年以来，"不明原因的 ACD "发病率有所下降。最常报告的过敏原是金属，其次是化妆品。结论1998年至2016年，工作年龄段人群的ACD发病率有所上升，尤其是女性。然而，自 2016 年以来，发病率一直在下降。我们的研究结果凸显了 ACD 在工作年龄人群中的持续甚至不断增加的负担。

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Allergic contact dermatitis to octyl and butylcyanoacrylate as well as formaldehyde in Leukosan® surgical glue. 对辛基和丁基氰基丙烯酸酯以及 Leukosan® 手术胶水中的甲醛过敏的接触性皮炎。

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis

Pub Date : 2024-09-07 DOI: 10.1111/cod.14689

Antoine Badaoui, Anne-Claire Fougerousse, Aude Roussel

引用次数: 0

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