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Benzoyl Peroxide's Sensitisation Potential and Potency in Experimental Methods and Review of Contact Allergy and Allergic Contact Dermatitis.
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-02-05 DOI: 10.1111/cod.14765
Kerstin Egele, Hans Drexler, Manigé Fartasch, Vera van Kampen, Hans F Merk, Dennis Nowak, Axel Schnuch, Wolfgang Uter, Patricia Kreis, Brunhilde Blömeke

Positive patch test responses to benzoyl peroxide (BPO) have been reported from patients without and with known exposure. Up to 6.5% were found in the United States and 7.8% in a study including patients from Germany, Austria and Switzerland. We provide an overview of the skin sensitisation potential and potency of BPO based on animal experiments and non-animal methods. BPO tested positive in Guinea Pig Tests and the Local Lymph Node Assay. Application of the current OECD guideline to identify a skin sensitizer by combining non-animal method results gave differing outcomes. Moreover, patch test responses of patients to BPO were considered to determine the importance of BPO as a relevant occupational contact allergen. Another well-known BPO exposure is the topical application to treat acne. Despite widespread use, extensive and long-term skin exposure, we found for this group only studies reporting few positive patch test reactions. Further, occupational handling of BPO and contact allergy is reported by dental technicians. In-depth evaluation of the prevalence of contact allergy in different professions with suspected BPO exposure did not reveal an association with occupational handling of BPO. Consequently, a generally increased risk for those professions is not supported.

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引用次数: 0
Correction to "Using Chemical Speciation Modelling to Discuss Variations in Patch Test Reactions to Different Aluminium and Chromium Salts".
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-29 DOI: 10.1111/cod.14766
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引用次数: 0
Allergic Contact Dermatitis to Both Latanoprost and Dorzolamide in Eye Drops.
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-27 DOI: 10.1111/cod.14761
Antoine Badaoui
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引用次数: 0
If Left to Your Own Devices, Consider Colophony.
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-27 DOI: 10.1111/cod.14762
E Dimitra Bednar, Joel G DeKoven
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引用次数: 0
Allergic Contact Dermatitis From Colophonium in Upholstery Adhesive: Two Case Reports of a Novel Source.
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-25 DOI: 10.1111/cod.14760
Esen Özkaya, Yasemin Erdem, İmran Can Özdemir, Tuğrul Furkan Morgül
{"title":"Allergic Contact Dermatitis From Colophonium in Upholstery Adhesive: Two Case Reports of a Novel Source.","authors":"Esen Özkaya, Yasemin Erdem, İmran Can Özdemir, Tuğrul Furkan Morgül","doi":"10.1111/cod.14760","DOIUrl":"https://doi.org/10.1111/cod.14760","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Allergic Contact Dermatitis to Hair Dye in a Patient With Atopic Dermatitis During Dupilumab Therapy. 杜比单抗治疗期间特应性皮炎患者对染发剂的严重过敏性接触性皮炎。
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-21 DOI: 10.1111/cod.14759
Alessandra Chiei Gallo, Gianluca Tavoletti, Gianluca Avallone, Eleonora Bono, Francesca Barei, Paolo Calzari, Angelo Valerio Marzano, Silvia Mariel Ferrucci
{"title":"Severe Allergic Contact Dermatitis to Hair Dye in a Patient With Atopic Dermatitis During Dupilumab Therapy.","authors":"Alessandra Chiei Gallo, Gianluca Tavoletti, Gianluca Avallone, Eleonora Bono, Francesca Barei, Paolo Calzari, Angelo Valerio Marzano, Silvia Mariel Ferrucci","doi":"10.1111/cod.14759","DOIUrl":"https://doi.org/10.1111/cod.14759","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dupilumab-Associated Unmasking of Allergic Contact Dermatitis. dupilumab相关的过敏性接触性皮炎的揭露。
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-21 DOI: 10.1111/cod.14758
Beatriz F Vilela, Pedro S Farinha, Bruno Duarte, Ana Brasileiro
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引用次数: 0
Allergens Responsible for Contact Allergy in Children From 2010 to 2024: A Systematic Review and Meta-Analysis. 2010年至2024年儿童接触性过敏的过敏原:系统回顾和荟萃分析。
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-19 DOI: 10.1111/cod.14753
Daniel Isufi, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Farzad Alinaghi, Jakob Ferløv Baselius Schwensen, Jeanne D Johansen

Contact allergy (CA) is a frequent condition in children; however, newer estimates of the prevalence of CA in children are lacking. Herein, we aim to provide an estimate of the prevalence of CA in children from 2010 to 2024. Two authors independently searched PubMed, Embase and Web of Science for studies reporting the prevalence of positive patch tests (PPTs) to allergens in populations including ≥ 100 children (< 18 years). Proportion meta-analyses were conducted to calculate the pooled prevalence estimates of CA in children. Seventeen studies comprising 11 593 children undergoing patch testing with 4176 (36%) PPTs were eligible for inclusion. The allergen with the highest prevalence was nickel (11.9% [95% confidence interval [CI], 8.6%-15.71%]), followed by cobalt (6.6% [95% CI, 4.2%-9.5%]), cocamidopropyl betaine (5.5% [95% CI, 3.1-8.7]), bacitracin (5.2% [95% CI, 1.2%-10.0%]), fragrance mix I (4.8% [95% CI, 2.9%-7.1%]) and methylisothiazolinone (4.3% [95% CI, 2.2%-7.2%]). Children with atopic dermatitis had higher rates of PPTs for cocamidopropyl betaine, propylene glycol, lanolin alcohol and carba mix. Across geographical areas, higher prevalences of several allergens were found in the United States compared to Europe, for example, for methylisothiazolinone. This meta-analysis confirmed that CA is frequent in children across geographical areas; however, differences in the frequency of top allergens depend on regulatory interventions, indicating their value.

接触性过敏(CA)是儿童的常见病;然而,缺乏对儿童CA患病率的最新估计。在此,我们的目标是提供2010年至2024年儿童CA患病率的估计。两位作者独立检索了PubMed、Embase和Web of Science,以获取报告对过敏原进行贴片试验阳性(PPTs)的流行率的研究,其中包括≥100名儿童(
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引用次数: 0
Type I Hypersensitivity due to Basic Blue 99 in a Hair Colour Conditioning Agent. 一种发色调理剂中的碱性蓝99引起的I型过敏。
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-13 DOI: 10.1111/cod.14755
Takafumi Numata, Kazuki Fujimori, Kana Kato, Tomonobu Ito, Kazutoshi Harada, Yukari Okubo
{"title":"Type I Hypersensitivity due to Basic Blue 99 in a Hair Colour Conditioning Agent.","authors":"Takafumi Numata, Kazuki Fujimori, Kana Kato, Tomonobu Ito, Kazutoshi Harada, Yukari Okubo","doi":"10.1111/cod.14755","DOIUrl":"https://doi.org/10.1111/cod.14755","url":null,"abstract":"","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 'MOAHLFA(P) Index': An Attempt to Standardise a Widely Used Array of Descriptors of Patch-Tested Patients. “MOAHLFA(P)指数”:尝试标准化广泛使用的贴片检测患者描述符阵列。
IF 4.8 1区 医学 Q2 ALLERGY Pub Date : 2025-01-12 DOI: 10.1111/cod.14750
Wolfgang Uter, Klaus Ejner Andersen, Richard Brans, Magnus Bruze, Steffen Schubert, Margarida Gonçalo

Background: Since its inception in 1980, the MOHL index (% patients who are male, have occupational, hand, or leg dermatitis, respectively) and its later evolutions until the presently used MOAHLFA(P) index (adding % patients with atopic dermatitis, face dermatitis, age 40+ years and positive reaction(s) to ≥ 1 baseline series allergen) have been intended to convey important demographic and clinical information on the patients patch tested in a certain area and time, aiding the interpretation of the observed spectrum of sensitisation.

Objectives: To examine the current usage of the MOAHLFA(P) index and suggest consolidated definitions for its single items.

Methods: A title/abstract search in Medline identified publications mentioning the evolving acronyms. A Delphi-like survey among contact dermatitis experts collected agreement with suggested definitions.

Results: The search term 'MOAHLFA' was used in 35 publications from a broad geographical origin. More than 80% of the 24 participants of the survey (65% response) agreed on maintaining to use (i) sex for the 'M' criterion, (ii) occupation-related dermatitis irrespective of medicolegal definitions for the 'O', (iii) atopic dermatitis (but not rhinitis or asthma) for the 'A'. The possibility to use more than one site among 'H', 'L' and 'F' and a more detailed description of age distribution were favoured, and the difficult interpretability of the 'P' measure was highlighted.

Conclusions: The 'classical' MOAHLFA(P) index may be extended. Some aspects, notably atopic dermatitis, need further standardisation.

背景:自 1980 年推出以来,MOHL 指数(男性、职业性皮炎、手部皮炎或腿部皮炎患者的百分比)及其后来的演变,直至目前使用的 MOAHLFA(P) 指数(添加特应性皮炎、面部皮炎、年龄在 40 岁以上且对≥ 1 种基线系列过敏原呈阳性反应的患者的百分比)都旨在传达在特定地区和时间进行贴片测试的患者的重要人口统计学和临床信息,从而帮助解释观察到的致敏谱系:研究 MOAHLFA(P)指数的当前使用情况,并对其单项的综合定义提出建议:方法:在 Medline 中进行标题/摘要检索,找出提及不断演变的缩写的出版物。在接触性皮炎专家中进行德尔菲式调查,收集对建议定义的一致意见:结果:搜索词 "MOAHLFA "出现在 35 篇来自不同地区的出版物中。在 24 位参与调查的人员中,超过 80% 的人员(65% 的回复率)同意坚持使用以下标准:(i) 性别作为 "M "标准;(ii) 职业相关皮炎(无论医学法律定义如何)作为 "O "标准;(iii) 特应性皮炎(但不包括鼻炎或哮喘)作为 "A "标准。在 "H"、"L "和 "F "中使用一个以上部位的可能性以及对年龄分布的更详细描述受到青睐,"P "指标难以解释的问题也得到了强调:结论:"经典 "的 MOAHLFA(P)指数可以扩展。结论:"经典 "MOAHLFA(P)指数可以扩展,但某些方面(尤其是特应性皮炎)需要进一步标准化。
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引用次数: 0
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Contact Dermatitis
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