New approaches to the control of chronic inflammatory diseases with a focus on the endolysosomal system of immune cells.

IF 4.8 4区 医学 Q2 IMMUNOLOGY International immunology Pub Date : 2024-07-01 DOI:10.1093/intimm/dxae041
Noriko Toyama-Sorimachi
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Abstract

Chronic inflammation is implicated in many types of diseases, including cardiovascular, neurodegenerative, metabolic, and immune disorders. The search for therapeutic targets to control chronic inflammation often involves narrowing down the various molecules associated with pathology that have been discovered by various omics analyses. Herein, a different approach to identify therapeutic targets against chronic inflammation is proposed and one such target is discussed as an example. In chronically inflamed tissues, a large number of cells receive diverse proinflammatory signals, the intracellular signals are intricately integrated, and complicated intercellular interactions are orchestrated. This review focuses on effectively blocking this chaotic inflammatory signaling network via the endolysosomal system, which acts as a cellular signaling hub. In endolysosomes, the inflammatory signals mediated by pathogen sensors, such as Toll-like receptors, and the signals from nutrient and metabolic pathways are integrally regulated. Disruption of endolysosome signaling results in a strong anti-inflammatory effect by disrupting various signaling pathways, including pathogen sensor-mediated signals, in multiple immune cells. The endolysosome-resident amino acid transporter, solute carrier family 15 member 4 (SLC15A4), which plays an important role in the regulation of endolysosome-mediated signals, is a promising therapeutic target for several inflammatory diseases, including autoimmune diseases. The mechanisms by which SLC15A4 regulates inflammatory responses may provide a proof of concept for the efficacy of therapeutic strategies targeting immune cell endolysosomes.

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控制慢性炎症性疾病的新方法,重点关注免疫细胞的内溶酶体系统。
慢性炎症与多种疾病有关,包括心血管疾病、神经退行性疾病、代谢性疾病和免疫性疾病。要寻找控制慢性炎症的治疗靶点,通常需要缩小通过各种全局分析发现的与病理有关的各种分子的范围。本文提出了一种不同的方法来确定慢性炎症的治疗靶点,并以其中一个靶点为例进行了讨论。在慢性炎症组织中,大量细胞接收各种促炎症信号,细胞内信号错综复杂,细胞间相互作用错综复杂。本综述的重点是通过作为细胞信号枢纽的内溶酶体系统有效阻断这一混乱的炎症信号网络。在内溶酶体中,由病原体传感器(如 Toll 样受体)介导的炎症信号以及来自营养和代谢途径的信号受到综合调控。干扰内溶酶体信号会导致多种免疫细胞中的各种信号通路(包括病原体传感器介导的信号)中断,从而产生强烈的抗炎效果。内溶酶体驻留氨基酸转运体--溶质运载家族 15 成员 4(SLC15A4)在调节内溶酶体介导的信号中发挥着重要作用,是包括自身免疫性疾病在内的多种炎症性疾病的有望治疗靶点。SLC15A4调控炎症反应的机制可能为针对免疫细胞内溶酶体的治疗策略的疗效提供概念证明。
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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
期刊最新文献
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