Frontal white and gray matter abnormality in gambling disorder: A multimodal MRI study.

IF 6.6 1区 医学 Q1 PSYCHIATRY Journal of Behavioral Addictions Pub Date : 2024-06-26 DOI:10.1556/2006.2024.00031
Albert Bellmunt-Gil, Victor Vorobyev, Riitta Parkkola, Jyrki Lötjönen, Juho Joutsa, Valtteri Kaasinen
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Abstract

Background: Changes in brain structural connections appear to be important in the pathophysiology of substance use disorders, but their role in behavioral addictions, such as gambling disorder (GD), is unclear. GD also offers a model to study addiction mechanisms without pharmacological confounding factors. Here, we used multimodal MRI data to examine the integrity of white matter connections in individuals with GD. We hypothesized that the affected areas would be in the fronto-striatal-thalamic circuit.

Methods: Twenty individuals with GD (mean age: 64 years, GD duration: 15.7 years) and 40 age- and sex-matched healthy controls (HCs) underwent detailed clinical examinations together with brain 3T MRI scans (T1, T2, FLAIR and DWI). White matter (WM) analysis involved fractional anisotropy and lesion load, while gray matter (GM) analysis included voxel- and surface-based morphometry. These measures were compared between groups, and correlations with GD-related behavioral characteristics were examined.

Results: Individuals with GD showed reduced WM integrity in the left and right frontal parts of the corona radiata and corpus callosum (pFWE < 0.05). WM gambling symptom severity (SOGS score) was negatively associated to WM integrity in these areas within the left hemisphere (p < 0.05). Individuals with GD also exhibited higher WM lesion load in the left anterior corona radiata (pFWE < 0.05). GM volume in the left thalamus and GM thickness in the left orbitofrontal cortex were reduced in the GD group (pFWE < 0.05).

Conclusions: Similar to substance addictions, the fronto-striatal-thalamic circuit is also affected in GD, suggesting that this circuitry may have a crucial role in addictions, independent of pharmacological substances.

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赌博障碍的额叶白质和灰质异常:多模态核磁共振成像研究
背景:大脑结构连接的变化在药物使用障碍的病理生理学中似乎很重要,但它们在行为成瘾(如赌博障碍)中的作用还不清楚。赌博障碍也为研究成瘾机制提供了一个没有药理混杂因素的模型。在这里,我们使用多模态核磁共振成像数据研究了 GD 患者白质连接的完整性。我们假设受影响的区域位于前额纹状体-丘脑回路:20 名 GD 患者(平均年龄:64 岁,GD 病程:15.7 年)和 40 名年龄和性别匹配的健康对照组(HCs)接受了详细的临床检查和脑 3T MRI 扫描(T1、T2、FLAIR 和 DWI)。白质(WM)分析包括分数各向异性和病变负荷,而灰质(GM)分析包括基于体素和表面的形态测量。这些测量结果在各组之间进行了比较,并考察了与广东话相关的行为特征的相关性:结果发现:GD患者放射冠和胼胝体的左右额叶部分的WM完整性降低(pFWE < 0.05)。WM赌博症状严重程度(SOGS评分)与左半球这些区域的WM完整性呈负相关(p<0.05)。GD患者的左侧放射冠前部也表现出较高的WM病变负荷(pFWE < 0.05)。GD组患者左侧丘脑的GM体积和左侧眶额皮层的GM厚度均有所减少(pFWE < 0.05):结论:与药物成瘾类似,前额叶-纹状体-丘脑回路在 GD 中也受到影响,这表明该回路可能在成瘾中起着关键作用,与药物无关。
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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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