TiO2 nanotubes with customized diameters for local drug delivery systems

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-07-01 DOI:10.1002/jbm.b.35445
Sayaka Miyabe, Yushi Fujinaga, Hiroaki Tsuchiya, Shinji Fujimoto
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Abstract

In this study, we evaluated the drug release behavior of diameter customized TiO2 nanotube layers fabricated by anodization with various applied voltage sequences: conventional constant applied potentials of 20 V (45 nm) and 60 V (80 nm), a 20/60 V stepped potential (50 nm [two-diameter]), and a 20–60 V swept potential (49 nm [full-tapered]) (values in parentheses indicate the inner tube diameter at the top part of nanotube layers). The structures of the 50 nm (two-diameter) and 49 nm (full-tapered) samples had smaller inner diameters at the top part of nanotube layers than that of the 80 nm sample, while the outer diameters at the bottom part of nanotube layers were almost the same size as the 80 nm sample. The 80 nm sample, which had the largest nanotube diameter and length, exhibited the greatest burst release, followed by the 50 nm (two-diameter), 49 nm (full-tapered), and 45 nm samples. The initial burst released drug amounts and release rates from the 50 nm (two-diameter) and 49 nm (full-tapered) samples were significantly suppressed by the smaller tube top. On the other hand, the largest proportion of the slow released drug amount to the total released drug amount was observed for the 50 nm (two-diameter) sample. Thus, 50 nm (two-diameter) achieved suppressed initial burst release and large storage capacity. Therefore, this study has, for the first time, applied TiO2 nanotube layers with modulated diameters (two-diameter and full-tapered) to the realization of a localized drug delivery system (LDDS) with customized drug release properties.

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用于局部给药系统的定制直径二氧化钛纳米管。
在本研究中,我们评估了通过阳极氧化制造的直径定制 TiO2 纳米管层的药物释放行为,这些纳米管层采用了不同的外加电压序列:20 V(45 nm)和 60 V(80 nm)的传统恒定外加电位、20/60 V 的阶跃电位(50 nm [双直径])和 20-60 V 的扫频电位(49 nm [全锥形])(括号中的值表示纳米管层上部的内管直径)。50 nm(双径)和 49 nm(全锥形)样品的纳米管层上部内径小于 80 nm 样品,而纳米管层下部外径与 80 nm 样品几乎相同。纳米管直径和长度最大的 80 nm 样品的猝灭释放量最大,其次是 50 nm(双径)、49 nm(全锥形)和 45 nm 样品。由于管顶较小,50 nm(双径)和 49 nm(全锥形)样品的初始猝灭释放药物量和释放速率明显受到抑制。另一方面,在 50 纳米(双直径)样品中观察到的缓释药物量占总释放药物量的比例最大。因此,50 nm(双直径)实现了抑制初始猝发释放和较大的存储容量。因此,本研究首次将直径可调(双径和全锥形)的 TiO2 纳米管层用于实现具有定制药物释放特性的局部给药系统(LDDS)。
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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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