Negative excess oral and pharyngeal cancer mortality in Europe during the early pandemic years.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2025-01-01 Epub Date: 2024-06-27 DOI:10.1111/odi.15055

Stefano Petti

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引用次数: 0

Abstract

Objective: The COVID-19 pandemic had direct and indirect effects on oral and pharyngeal cancer (OPC) mortality due to high COVID-19 mortality risk among cancer patients, and to the COVID-19 response that caused treatment delays and reduced routine visits. This study investigated the excess OPC mortality in Europe during the early pandemic years.

Methods: Mortality and population data were gathered from the Eurostat database. The 2011-2019 mortality rates were used to estimate the 2020-2021 expected rates through joinpoint trend analysis. The excess mortality rates (observed minus expected mortality) with 95% confidence intervals (95 CIs) were assessed.

Results: Statistically significant negative excess age-standardized and crude (age strata <65 and ≥65 years) OPC mortality rates in males and females, in the European Union (EU, 27 countries) and Europe were reported. The estimated OPC missing deaths in EU were 831 (95 CI, 630-985) and 1240 (95 CI, 1039-1394) in 2020 and 2021, respectively, with differences between sexes, age strata, and countries. The OPC deaths in the EU and Europe were 3.6% and 3.5% lower than expected.

Conclusion: Missing OPC deaths reported in Europe in 2020-2021 could be explained by changes in death certification of OPC patients who developed COVID-19, rather than a real OPC mortality decline.

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大流行初期欧洲口腔癌和咽癌死亡率负增长。

目的：COVID-19大流行对口腔癌和咽癌（OPC）死亡率产生了直接和间接的影响，这是因为癌症患者的COVID-19死亡率风险较高，而且COVID-19应对措施导致治疗延迟和常规就诊减少。本研究调查了大流行初期欧洲过高的 OPC 死亡率：方法：死亡率和人口数据来自欧盟统计局数据库。通过连接点趋势分析，利用 2011-2019 年的死亡率估算出 2020-2021 年的预期死亡率。评估了超额死亡率（观察死亡率减去预期死亡率）及 95% 置信区间（95 CI）：结果：统计意义上的负超额年龄标准化死亡率和粗死亡率（年龄分层结论：在 2020-2021 年报告的缺失 OPC 死亡率中，年龄标准化死亡率和粗死亡率均为负值：2020-2021 年欧洲报告的缺失的 OPC 死亡病例可能是由于患 COVID-19 的 OPC 患者的死亡证明发生了变化，而不是真正的 OPC 死亡率下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.